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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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adaptive mechanism, similarly to what was reported in some elderly euthyroid patients. In fact, some authors have reported that pituitary sensitivity to TH may increase with age and about 3% of elderly outpatients, display an inappropriately low fT4
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independent risk factor for all-cause mortality in euthyroid elderly adults, while neither FT3 nor FT4 exhibited any association with mortality ( 17 ). The direct correlation between TSH levels or thyroid hormones and all-cause mortality necessitates further
Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China
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Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Heping District, Shenyang, Liaoning, China
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Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China
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, depressive symptoms, fatigue, cognitive function, muscle strength, and BMI in treated vs untreated older people with SCH ( 21 ). Another study found that LT4 had no obvious benefit to elderly patients with SCH ( 22 , 23 ). In the present study, we found that
Department of Endocrinology, Portuguese Institute of Oncology, Lisbon, Portugal
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American Association of Clinical Endocrinologists. Thyroid 2011;21:593-646. 10.1089/thy.2010.0417 21510801 15 Laurberg P, Pedersen KM, Vestergaard H, Sigurdsson G: High incidence of multinodular toxic goitre in the elderly population in a low iodine
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University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital, Basel, Switzerland
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Division of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland
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a lack in statistical power, and one study reported higher same-day rehospitalizations in men after outpatient thyroidectomies [ 6 , 15 , 27 ]. So far, higher readmission rates up to 11% have been reported in elderly patients (>65 years) and those
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]. Alternatively, preparation for radioiodine treatment with rhTSH instead of THW has been proposed to induce less bone marrow toxicity. rhTSH preparation is associated with a lower red marrow absorbed dose [ 31 ], and in a study performed in 15 elderly DTC
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depression section of Diagnostic Interview Schedule) in 6,869 young adults from the US [ 16 ] and worse psychological well-being (by self-reported questionnaire) in 2,269 men from the UK [ 17 ]. Two large studies in elderly subjects from the UK [ 18 ] and
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Japan
Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Japan
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]. The main difference between these 2 models is whether PTMs, once stopping growth, resume proliferation in the elderly. Although data from long-term observation trials of PTMs have been presented, there is no report of a PTM turning into a lethal cancer
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situations, such as patients with renal insufficiency [ 24 ], children [ 25 ], the elderly [ 26 ], and patients with extensive pulmonary metastasis [ 4 ]. While small series have suggested favorable outcomes for dosimetrically determined RAI administration in
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cardiovascular morbidity (arrhythmia, cardiomyopathy, stroke) and mortality, particularly in the elderly. Likewise, hyperthyroidism is an established risk factor for osteoporosis in postmenopausal women. These epidemiological findings have recently led to a