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Enrico Papini Department of Endocrinology and Metabolism, Regina Apostolorum Hospital, Rome, Italy

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Hervé Monpeyssen Thyroid Unit, American Hospital, Paris, France

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Andrea Frasoldati Department of Endocrinology and Metabolism, Arcispedale Santa Maria Nuova IRCCS-ASL, Reggio Emilia, Italy

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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of the neck with an ice pack may be useful for preventing local bleeding and thermal injury to the skin. After treatment, clinical and US evaluation is needed for detection of potential early adverse effects of the procedure (e.g., hematoma, burns, or

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Carla Gambale Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Alessandro Prete Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Lea Contartese Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Liborio Torregrossa Department of Surgical, Medical, Molecular Pathology and Critical Area, Anatomic Pathology Section, University Hospital of Pisa, Pisa, Italy

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Francesca Bianchi Department of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy

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Eleonora Molinaro Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Gabriele Materazzi Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Endocrine Surgery, University Hospital of Pisa, Pisa, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Antonio Matrone Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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regulations of the Helsinki Declaration and was approved by the local ethical committee (CEAVNO – Comitato Etico Area Vasta Nord Ovest). Initial treatment Total thyroidectomy was performed in all patients. Since, in our institution, we do not perform

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Vittoria Guarda Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany

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Anja Pickhard Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany

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Melanie Boxberg Institute of Pathology, Technical University of Munich, Munich, Germany

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Katja Specht Institute of Pathology, Technical University of Munich, Munich, Germany

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Anna Maria Stefanie Buchberger Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany

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What Is Known about This Topic? Liposarcomas of the thyroid gland are extremely rare, and there is no definitive consensus within the literature about a comprehensive treatment recommendation yet. What Does This Case Report Add

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Laura Valerio Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Carlotta Giani Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Laura Agate Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Eleonora Molinaro Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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David Viola Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Valeria Bottici Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Antonio Matrone Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Luciana Puleo Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Loredana Lorusso Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Virginia Cappagli Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Alessandro Ribechini Department of Thoracic Endoscopy, University Hospital of Pisa, Pisa, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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approved for the treatment of these patients based on the results of phase III studies (DECISION and SELECT studies) [ 2 , 3 ]. Like many other TKIs, lenvatinib is a multiple kinase inhibitor and inhibits the 3 main vascular endothelial growth factor

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Jeppe Lerche la Cour Center for Endocrinology and Metabolism, Department of Internal Medicine, Herlev and Gentofte Hospitals, Herlev, Denmark

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Line Tang Møllehave Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Capital Region, Denmark

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Bjarke Røssner Medici Center for Endocrinology and Metabolism, Department of Internal Medicine, Herlev and Gentofte Hospitals, Herlev, Denmark

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Christian Zinck Jensen Center for Endocrinology and Metabolism, Department of Internal Medicine, Herlev and Gentofte Hospitals, Herlev, Denmark

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Anne Ahrendt Bjerregaard Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Capital Region, Denmark

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Birte Nygaard Center for Endocrinology and Metabolism, Department of Internal Medicine, Herlev and Gentofte Hospitals, Herlev, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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endocrinologists who are more prone to start L-T3 treatment than GPs. We also demonstrated that the region of residence was related to initiating this treatment. The explanation could be that local doctors’ preferences follow key opinion leaders that are more

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Marta Di Stefano Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Carla Colombo Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Simone De Leo Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Michela Perrino Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Mauro Viganò Division of Hepatology, San Giuseppe Hospital Multimedica IRCCS, Milan, Italy

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Luca Persani Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Clinical Sciences and Community Health, Milan, Italy

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Laura Fugazzola Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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-R DTC), and it has been recently approved also for the treatment of patients with advanced or unresectable hepatocellular carcinoma (HCC) [ 2 ]. In RAI-R DTC patients on LEN treatment, several adverse events (AEs) have been reported in almost all treated

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Furio Pacini Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy

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surgical complications with the evidence that a second operation rarely results in permanent cure of the neck. Local treatment options are very attractive. Good results have been reported with ethanol injection, but the above-mentioned new techniques seem

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Luigi Bartalena Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy

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are in the end unhappy with the treatment outcome [ 2 ]. After medical treatment, many patients require some kind of rehabilitative surgery (orbital decompression, squint surgery, eyelid surgery) to correct residual manifestations. The reasons for this

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Ola Lindgren Department of Endocrinology, Lund University, Malmö, Sweden
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden

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Pernilla Asp Department of Oncology, Skåne University Hospital, Lund, Sweden

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Anna Sundlöv Department of Oncology, Lund University, and Department of Clinical Sciences, Skåne University Hospital, Lund, Sweden

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Jan Tennvall Department of Oncology, Lund University, and Department of Clinical Sciences, Skåne University Hospital, Lund, Sweden

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Bushra Shahida Department of Clinical Sciences Malmö, and Diabetes and Endocrinology, Lund University, Malmö, Sweden

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Tereza Planck Department of Endocrinology, Lund University, Malmö, Sweden
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden

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Peter Åsman Department of Clinical Sciences Malmö, Ophthalmology, Lund University, and Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden

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Mikael Lantz Department of Endocrinology, Lund University, Malmö, Sweden
Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden

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[ 1 , 2 ] and environmental factors [ 3 ]. One strong risk factor is tobacco smoking, which results in higher TRAb at diagnosis of GD and during treatment with thiamazole than in nonsmokers [ 4 ]. It has also been shown that smokers treated with

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Francisco Sousa Santos Endocrinology Department, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Rita Joana Santos Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Faculty of Medical Sciences of Lisbon, Lisbon, Portugal

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radiation due to local disease persistence (9 patients) and bone (9 patients) or brain metastasis (1 patient); these lesions were not considered for the RECIST assessments. A total of 36 treatment courses were evaluated – 26 with sorafenib and 10 with

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