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Introduction Thyroid lesions with a follicular pattern, which is defined as the cells arranged around a central lumen containing colloid material, consist of a large group of thyroid neoplasms, including follicular adenoma (FA), follicular
Center for Genomic Research, Italy
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Azienda USL of Modena, Modena, Italy
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Azienda USL of Modena, Modena, Italy
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Center for Genomic Research, Italy
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Center for Genomic Research, Italy
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Azienda USL of Modena, Modena, Italy
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Azienda USL of Modena, Modena, Italy
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Center for Genomic Research, Italy
Azienda USL of Modena, Modena, Italy
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Introduction BRAF point mutations are common in papillary thyroid cancer (PTC) [ 1 ]. The most frequent missense mutation BRAF V600E is due to the replacement of valine by glutamic acid (NM_004333.4), resulting in a constitutive MEK
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Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy
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Introduction Nodular thyroid disease is a common finding, especially in females and in the elderly population. Thyroid nodules are found in 5% of the general population with the use of palpation [ 1 ], but high-resolution ultrasonography (US
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(GTT), which results from the direct stimulatory effect of human chorionic gonadotrophin on the thyroid gland, is also fairly common and accounts for ∼10% of cases. It most often presents as a subclinical hyperthyroidism in the first half of gestation
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Introduction Thyroid nodules are common, being present by palpation in up to 5% of individuals and by ultrasonography (US) in up to 50% [ 1 ]. While the overwhelming majority are benign, it is estimated that the incidence of cancer in
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Introduction Thyroid nodules are a common finding in endocrine clinical practice. Their prevalence is approximately 5% when detected by palpation but may occur at 70% frequency when the thyroid is examined by ultrasound [ 1 - 3 ]. Most nodules
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Introduction Nodule development is a commonly seen entity in the thyroid gland, and 4–7% of the adult population has a palpable thyroid nodule [ 1 ]. With imaging modalities, especially the widespread use of ultrasound
Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
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observations is needed in hospitals with varying numbers of thyroid surgeries and experience. Therefore, we developed a symptom-based treatment algorithm for our multicenter thyroid network. A protocolized schedule to phase out supplementation was included
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Introduction An essential trace element, selenium (Se) is required for correct immune system function and plays a key role in thyroid physiology [ 1 ]. Se is incorporated into the molecular structures of some proteins. These so
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal
Department of Pathology and Oncology, Centro Hospitalar São João, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
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Introduction Thyroid cancer is the most common of all endocrine malignancies. Despite the advances in its genetic characterization, many authors now accept that about 30% of thyroid cancer cases are in a genetic “dark zone” due to the lack of