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Eijun Nishihara Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yoshitaka Hobo ASKA Pharmamedical Co., Ltd. Fujisawa, Japan

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Akira Miyauchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yasuhiro Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Miyoko Higuchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuyoshi Hirokawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuru Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Shuji Fukata Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsushige Nishikawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Takashi Akamizu Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Introduction Thyroglobulin (Tg) is a thyroid-specific protein, and its serum levels are useful for monitoring patients with differentiated thyroid carcinomas (DTCs) who underwent total thyroidectomy. However, anti-Tg antibodies (TgAb) are

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Ying Sun Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China

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Di Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China

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Lei Zhao Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Heping District, Shenyang, Liaoning, China

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Xiaoguang Shi Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China
Department of Endocrinology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China

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Yongze Li Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China

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Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China

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Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China

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Introduction Recent evidence has suggested that impaired thyroid hormone (TH) sensitivity is associated with obesity, metabolic syndrome, diabetes, and diabetes-related mortality even in those with a normothyroid range ( 1 ). Aging modulates

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Stan R Ursem Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands

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Anita Boelen Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Eveline Bruinstroop Department of Endocrinology and Metabolism, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands

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Petra J M Elders Department of General Practice, Amsterdam UMC Location Vrije Universiteit, Amsterdam, The Netherlands
Amsterdam Public Health Research Institute, Amsterdam UMC, The Netherlands

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Jacobijn Gussekloo LUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands

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Rosalinde K E Poortvliet LUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands

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Annemieke C Heijboer Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands

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Wendy P J den Elzen Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Public Health Research Institute, Meibergdreef, Amsterdam, The Netherlands

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Background Subclinical thyroid diseases are often the subject of debate concerning their clinical significance, the appropriateness of diagnostic testing, and possible treatment. In subclinical hyperthyroidism, there is a mild thyroid

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Enrico Papini Department of Endocrinology and Metabolism, Regina Apostolorum Hospital, Rome, Italy

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Hervé Monpeyssen Thyroid Unit, American Hospital, Paris, France

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Andrea Frasoldati Department of Endocrinology and Metabolism, Arcispedale Santa Maria Nuova IRCCS-ASL, Reggio Emilia, Italy

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Scope of the Document Thyroid nodules are common in the adult population with a prevalence at ultrasound (US) examination of up to 50% in adult females and 30% in males [ 1 - 3 ]. Most lesions are cytologically benign and neither cause local

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Elske T. Massolt Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Mahdi  Salih Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands

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Carolien M. Beukhof Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Boen L.R. Kam Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands

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J.W. Burger Division of Surgical Oncology, Department of Surgery, Erasmus MC, Rotterdam, The Netherlands

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W. Edward Visser Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Ewout J. Hoorn Department of Nephrology and Transplantation, Erasmus MC, Rotterdam, The Netherlands

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Robin P. Peeters Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Introduction Thyroid hormone (TH) is indispensable for the metabolism of all tissues. The importance of TH in normal physiology is well illustrated by primary thyroid diseases in which abnormal TH concentrations affect the function of several

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Tetsuya Mizokami Tajiri Thyroid Clinic, Kumamoto, Japan

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Katsuhiko Hamada Tajiri Thyroid Clinic, Kumamoto, Japan

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Tetsushi Maruta Tajiri Thyroid Clinic, Kumamoto, Japan

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Kiichiro Higashi Tajiri Thyroid Clinic, Kumamoto, Japan

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Junichi Tajiri Tajiri Thyroid Clinic, Kumamoto, Japan

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. What Does This Case Report Add? • Painful radiation thyroiditis after 131 I therapy for Graves' hyperthyroidism is associated with characteristic findings in the thyroid parenchyma as well as in the surrounding tissue on ultrasonography

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Cosimo Durante Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Agnieszka Czarniecka M. Sklodowska-Curie National Research, Institute of Oncology Gliwice Branch, Gliwice, Poland

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Ralf Paschke Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Gilles Russ Thyroid and Endocrine Tumors Department, Pitié-Salpêtrière Hospital, Sorbonne University GRC N°16, Paris, France

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Fernando Schmitt Faculty of Medicine of University of Porto, CINTESIS@RISE and Institute of Molecular Pathology and Immunology, University of Porto (Ipatimup), Porto, Portugal

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Paula Soares Institute of Investigation and Innovation in Health (I3S), Faculty of Medicine of the University of Porto, Porto, Portugal

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Tamas Solymosi Endocrinology and Metabolism Clinic, Bugat Hospital, Gyöngyös, Hungary

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Enrico Papini Department of Endocrine and Metabolic Diseases, Regina Apostolorum Hospital, Albano, Rome, Italy

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Introduction A thyroid nodule is a discrete lesion within the thyroid gland that is ultrasonographically distinct from the surrounding thyroid parenchyma. With the widespread use of sensitive imaging techniques, which include neck

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Shaodong Hou Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China

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Yiceng Sun Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Zeyu Yang Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Mi Tang Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Tingjie Yin Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Cong Shao Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Cunye Yan Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Linlong Mo Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Yuquan Yuan Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Supeng Yin Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Fan Zhang Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China

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Introduction By 2020, thyroid cancer had ranked as the fifth most prevalent cancer in women and the 11th most common cancer overall, with a sharp increase in its frequency worldwide ( 1 ). Papillary thyroid carcinoma (PTC) is the most common

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Neslihan Kurtulmus Endocrinology and Thyroid Clinic, Acibadem Maslak Hospital, Istanbul, Turkey

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Burak Ertas Departments of Otorhinolaryngology, Istanbul, Turkey

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Yesim Saglican Pathology, Medical Faculty, Acibadem University, Istanbul, Turkey

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Hakan Kaya Endocrinology and Thyroid Clinic, Acibadem Maslak Hospital, Istanbul, Turkey

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Umit Ince Pathology, Medical Faculty, Acibadem University, Istanbul, Turkey

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Mete Duren Endocrinology and Thyroid Clinic, Acibadem Maslak Hospital, Istanbul, Turkey

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Introduction Papillary thyroid cancer (PTC) is the most common type of endocrine cancer [ 1 ]. It originates from follicular epithelial cells and usually has a slow progression with a good prognosis. However, of note, it presents with a high

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Stéphane Bardet Department of Nuclear Medicine and Thyroid Unit, Centre François Baclesse, Caen, France

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Renaud Ciappuccini Department of Nuclear Medicine and Thyroid Unit, Centre François Baclesse, Caen, France

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Livia Lamartina Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy, Villejuif, France

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy, Villejuif, France

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selpercatinib. Introduction Serum tumour markers are important tools in the management of patients with medullary thyroid carcinoma (MTC) ( 1 ). Serum calcitonin (CT) and carcinoembryonic antigen (CEA) are produced by neoplastic C-cells, and their

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