Friederike Schütz
Friederike Schütz
Martin Luther University Halle-Wittenberg, Institute for Medical Epidemiology, Biostatistics and Informatics, Halle (Saale), Germany
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Christine Lautenschläger
Christine Lautenschläger
Martin Luther University Halle-Wittenberg, Institute for Medical Epidemiology, Biostatistics and Informatics, Halle (Saale), Germany
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Kerstin Lorenz
Kerstin Lorenz
Department of General, Visceral and Vascular Surgery, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
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Johannes Haerting
Johannes Haerting
Martin Luther University Halle-Wittenberg, Institute for Medical Epidemiology, Biostatistics and Informatics, Halle (Saale), Germany
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: Clinical value of technetium-99m-labeled octreotide scintigraphy in local recurrent or metastatic medullary thyroid cancers: a comparison of lesions with 18 F-FDG-PET and MIBI images. Nucl Med Commun 2013; 34: 1190–1195. 10.1097/MNM.0000000000000006
Hélène Théodon
Hélène Théodon
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Erell Guillerm
Erell Guillerm
Department of Oncogenetic, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Johanna Wassermann
Johanna Wassermann
Department of Oncology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Gabrielle Deniziaut
Gabrielle Deniziaut
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Loïc Jaffrelot
Loïc Jaffrelot
Department of Oncology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Jérome Denis
Jérome Denis
Department of Endocrine and Oncology Biochemistry, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris, France
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Nathalie Chereau
Nathalie Chereau
Department of Endocrine Surgery, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Claude Bigorgne
Claude Bigorgne
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Wiame Potonnier
Wiame Potonnier
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Florence Coulet
Florence Coulet
Department of Oncogenetic, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Laurence Leenhardt
Laurence Leenhardt
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Camille Buffet
Camille Buffet
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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interpretable samples. Regarding the NGS performed on the two poorly differentiated thyroid cancers, one showed no mutation and one was not interpretable. The most frequent molecular alteration found in the four recurrent medullary thyroid cancers patients was a
Francesca Carlomagno
Francesca Carlomagno
Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Università degli Studi di Napoli Federico II, Napoli, Italia
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)] against epithelial growth factor receptor (EGFR) in non-small cell lung carcinoma [ 34 ]. RET is a critical target for medullary thyroid cancer treatment [ 32 ]. Several small molecules are known to exert RET inhibition. Virtually all of them are believed
Francisco Sousa Santos
Francisco Sousa Santos
Endocrinology Department, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Rita Joana Santos
Rita Joana Santos
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Faculty of Medical Sciences of Lisbon, Lisbon, Portugal
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Faculty of Medical Sciences of Lisbon, Lisbon, Portugal
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included, for instance, patients with anaplastic and medullary thyroid cancer and addressed patients with first- and second-line treatment as a whole [ 8 - 10 , 16 ]. Still, our study seems to add to the interesting hypothesis that patients who have
Hao Li
Hao Li
Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Otorhinolaryngology, Tan Tock Seng Hospital, Singapore, Singapore
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Otorhinolaryngology, Tan Tock Seng Hospital, Singapore, Singapore
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Nir Livneh
Nir Livneh
Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Otolaryngology, Head and Neck Surgery, Sheba Medical Center, Ramat Gan, Israel
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Otolaryngology, Head and Neck Surgery, Sheba Medical Center, Ramat Gan, Israel
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Snjezana Dogan
Snjezana Dogan
Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
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Ashok R. Shaha
Ashok R. Shaha
Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
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.1200/JCO.2016.67.7419 . 11 Randle RW , Balentine CJ , Leverson GE , Havlena JA , Sippel RS , Schneider DF , . Trends in the presentation, treatment, and survival of patients with medullary thyroid cancer over the past 30 years
Carla Colombo
Carla Colombo
Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Daniele Ceruti
Daniele Ceruti
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Simone De Leo
Simone De Leo
Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
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Grzegorz Bilo
Grzegorz Bilo
Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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Matteo Trevisan
Matteo Trevisan
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Noemi Giancola
Noemi Giancola
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Claudia Moneta
Claudia Moneta
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Gianfranco Parati
Gianfranco Parati
Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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Luca Persani
Luca Persani
Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Laura Fugazzola
Laura Fugazzola
Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Introduction Multikinase inhibitors (MKIs) with strong anti-angiogenetic action are frequently used for the treatment of advanced radioiodine-refractory differentiated thyroid cancer (RAI-R DTC) or medullary thyroid cancers (MTCs) ( 1 , 2
Markus Eszlinger
Markus Eszlinger
Departments of Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany
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Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany
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Paul Stewardson
Paul Stewardson
Department of Medical Science and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada
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John B McIntyre
John B McIntyre
Precision Oncology Hub Laboratory, Alberta Health Services, Tom Baker Cancer Centre, Calgary, Alberta, Canada
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Adrian Box
Adrian Box
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Moosa Khalil
Moosa Khalil
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Martin Hyrcza
Martin Hyrcza
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Konstantin Koro
Konstantin Koro
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Dean Ruether
Dean Ruether
Section of Medical Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Jiahui Wu
Jiahui Wu
Department of Medical Science and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Ralf Paschke
Ralf Paschke
Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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mutation-positive medullary thyroid cancer (MTC) or RET gene fusion-positive thyroid cancer. The early approval of these drugs was based on phase 1/2 data ( 1 , 2 , 3 , 4 , 5 ). Patients with thyroid cancer were one of the larger patient groups in the
Pepijn van Houten
Pepijn van Houten
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands
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James Nagarajah
James Nagarajah
Roentgeninstitut Duesseldorf, Duesseldorf, Germany
Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Janneke E W Walraven
Janneke E W Walraven
Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands
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Martin Jaeger
Martin Jaeger
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands
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Adriana C H van Engen-van Grunsven
Adriana C H van Engen-van Grunsven
Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands
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Johannes W Smit
Johannes W Smit
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands
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Romana T Netea-Maier
Romana T Netea-Maier
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
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Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
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Swarts HG Gerrits D Boerman OC Koenderink JB Stunnenberg HG Netea MG Smit JWA Netea-Maier RT , et al . Digitalis-like compounds facilitate non-medullary thyroid cancer redifferentiation through intracellular Ca2+, FOS, and autophagy
Catarina Silvestre
Catarina Silvestre
Department of Endocrinology, Diabetes and Metabolism, Santa Maria Hospital, Lisbon, Portugal
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Joaquim Sampaio Matias
Joaquim Sampaio Matias
Department of Laboratorial Medicine, Santa Maria Hospital, Lisbon, Portugal
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Helena Proença
Helena Proença
Department of Laboratorial Medicine, Santa Maria Hospital, Lisbon, Portugal
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Maria João Bugalho
Maria João Bugalho
Department of Endocrinology, Diabetes and Metabolism, Santa Maria Hospital, Lisbon, Portugal
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outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders . J Clin Endocrinol Metab . 2004 Jan ; 89 ( 1 ): 163 – 8 . 10.1210/jc.2003-030550 14715844 0021-972X 16 Bugalho MJ , Santos JR
Amruth R. Palla
Amruth R. Palla
Division of Hematology and Oncology, Department of Internal Medicine, Ellis Fischel Cancer Center, University of Missouri Columbia, Columbia, Missouri, USA
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Craig Allen Bollig
Craig Allen Bollig
Department of Otolaryngology – Head and Neck Surgery, Ellis Fischel Cancer Center, University of Missouri Columbia, Columbia, Missouri, USA
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Jeffrey Brian Jorgensen
Jeffrey Brian Jorgensen
Department of Otolaryngology – Head and Neck Surgery, Ellis Fischel Cancer Center, University of Missouri Columbia, Columbia, Missouri, USA
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Epithelial cancers of the thyroid gland constitute the majority of thyroid malignancies (about 95%) and include papillary, follicular, hurtle cell, anaplastic, and medullary thyroid cancers. The nonepithelial cancers constitute less than 5% of all thyroid
