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Ayanthi Wijewardene Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Matti Gild Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Carolina Nylén Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Geoffrey Schembri Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Paul Roach Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Jeremy Hoang Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Ahmad Aniss Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Anthony Glover Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Mark Sywak Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Stan Sidhu Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Diana Learoyd Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Bruce Robinson Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Lyndal Tacon Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Roderick Clifton-Bligh Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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thyroidectomy for differentiated thyroid cancer for 3 reasons: to ablate remnant thyroid tissue in low-risk patients; prevent recurrent disease in high-risk patients (adjuvant therapy); or to treat residual or metastatic disease [ 5 ]. Clinical paradigms have

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Stamatina Ioakim CEDM, Centre of Endocrinology, Diabetes & Metabolism, Limassol, Cyprus
Medical School, University of Milan, Milan, Italy

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Akheel A Syed Department of Diabetes, Endocrinology & Obesity Medicine, Salford Royal NHS Foundation & University Teaching Trust, Salford, UK
Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

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George Zavros CEDM, Centre of Endocrinology, Diabetes & Metabolism, Limassol, Cyprus

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Michalis Picolos Alithias Endocrinology Centre, Nicosia, Cyprus

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Luca Persani Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
Department of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Angelos Kyriacou CEDM, Centre of Endocrinology, Diabetes & Metabolism, Limassol, Cyprus
Department of Diabetes, Endocrinology & Obesity Medicine, Salford Royal NHS Foundation & University Teaching Trust, Salford, UK
Medical School, European University of Cyprus, Nicosia, Cyprus

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). Reassuringly, a recent long-term study of a 17,500-patient cohort with nodules greater than 10 mm in size showed an even lower risk of malignancy at 1.1% ( 6 ). The latter study differed from previous studies in that there was less selection bias and papillary

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Line Tang Møllehave Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Nils Knudsen Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Denmark

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Allan Linneberg Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Inge Bülow Pedersen Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark

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Gitte Ravn-Haren Research Group for Risk Benefit, National Food Institute, Technical University of Denmark, Lyngby, Denmark

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Anja Lykke Madsen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Allan Carlé Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark

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Charlotte Cerqueira The Danish Clinical Quality Program – National Clinical Registries (RKKP), Denmark

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Anne Krejbjerg Department of Oncology, Aalborg University Hospital, Aalborg, Denmark

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Lone Banke Rasmussen Independent researcher, Klemensker, Denmark

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Lars Ovesen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Hans Perrild Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Denmark

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Lena Bjergved Sigurd Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark

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Betina Heinsbæk Thuesen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Pernille Vejbjerg Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark

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Torben Jørgensen Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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optimal thyroid health in the population. Both iodine deficiency (ID) and iodine excess are associated with an increased risk of thyroid disease, and the optimal distribution of the population’s iodine intake lies within a narrow range. Therefore, the

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Furio Pacini Section of Endocrinology, University of Siena, Siena, Italy

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Dagmar Fuhrer Department of Endocrinology, Diabetes and Metabolism, West German Cancer Centre (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Rossella Elisei Section of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Daria Handkiewicz-Junak Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland

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Sophie Leboulleux Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France

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Markus Luster Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany

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Martin Schlumberger Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France

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Johannes W Smit Radboud University Medical Center, Nijmegen, Netherlands

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frequently even undetectable serum thyroglobulin (Tg) levels (at least in the hands of large volume surgeons) on levothyroxine (LT4) treatment. In these cases, particularly in low-risk patients, the goal of remnant ablation is already achieved following the

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Aly Bernard Khalil Imperial College London Diabetes Center, Abu Dhabi, United Arab Emirates

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Roberto Dina Hammersmith Hospital, London, United Kingdom

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Karim Meeran Hammersmith Hospital, London, United Kingdom

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Ali M. Bakir Imperial College London Diabetes Center, Abu Dhabi, United Arab Emirates

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Saf Naqvi Imperial College London Diabetes Center, Abu Dhabi, United Arab Emirates

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Alia Al Tikritti Imperial College London Diabetes Center, Abu Dhabi, United Arab Emirates

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Nader Lessan Imperial College London Diabetes Center, Abu Dhabi, United Arab Emirates

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Maha T. Barakat Imperial College London Diabetes Center, Abu Dhabi, United Arab Emirates

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” diagnosis or Thy3 [ 8 , 9 ]. The reported risk of malignancy in this group is variable among different centers, ranging from 6 to 48% [ 10 ]. In this regard, the role of ultrasound has emerged as a practical and accurate tool in the risk stratification of

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Nicholas S. Andresen Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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John M. Buatti Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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Hamed H. Tewfik Iowa City Cancer Treatment Center, Iowa City, Iowa, USA

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Nitin A. Pagedar Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA

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Carryn M. Anderson Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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John M. Watkins Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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of curative-intent therapy, though in selected lower-risk cases, subtotal thyroidectomy or ultrasound-based surveillance may be considered [ 4 - 6 ]. When total thyroidectomy is performed, many patients with differentiated thyroid cancer are treated

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Jan Debeij Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden

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Suzanne C. Cannegieter Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden

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Bregje van Zaane Departments of Internal Medicine, Slotervaart Hospital
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands

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Anton P. van Zanten Departments of Clinical Biochemistry, Slotervaart Hospital

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Frits R. Rosendaal Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden

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Victor E.A. Gerdes Departments of Internal Medicine, Slotervaart Hospital
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands

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Pieter H. Reitsma Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden

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Olaf M. Dekkers Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Endocrinology and Metabolism, Leiden University Medical Centre, Leiden

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fibrillation. Haemorrhage is an important complication of anticoagulant treatment. Annually, 7-10% of patients treated with VKA suffer from haemorrhage, and 1-3% from major haemorrhage [ 1 , 2 ]. Several risk factors for a bleeding tendency have been identified

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Bernadette Biondi Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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Luigi Bartalena Department of Clinical and Experimental Medicine, University of Insubria, Endocrine Unit, Ospedale di Circolo, Varese, Italy

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David S. Cooper Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Md., USA

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Peter Laurberg Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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George J. Kahaly Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany

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strong recommendation (for or against) because the benefits outweighed the risks (or vice versa). Level 2 was a weak recommendation (for or against) in which the treatment depended on the patient's preference because the benefits and risks were uncertain

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Enrique Soto-Pedre Division of Population Health & Genomics, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom

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Moneeza K. Siddiqui Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom

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Ify Mordi Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom

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Cyrielle Maroteau Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom

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Jimena Soto-Hernaez School of Medicine, University of Bristol, Bristol, United Kingdom

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Colin N.A. Palmer Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom

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Ewan R. Pearson Division of Population Health & Genomics, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom

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Graham P. Leese Division of Population Health & Genomics, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
Department of Endocrinology and Diabetes, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom

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-related disorders. A recent meta-analysis of GWAS for thyroid function and dysfunction, testing up to 8 million genetic variants, developed a TSH-based genetic risk score (GRS) and reported its association with hypothyroidism, hyperthyroidism, and other endpoints

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Giulia Brigante Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria, Modena, Italy

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Clara Lazzaretti Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

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Elia Paradiso Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

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Federico Nuzzo Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

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Martina Sitti Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

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Frank Tüttelmann Institute of Reproductive Genetics, University of Münster, Münster, Germany

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Gabriele Moretti Department of Biology, University of Pisa, Pisa, Italy

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Roberto Silvestri Department of Biology, University of Pisa, Pisa, Italy

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Federica Gemignani Department of Biology, University of Pisa, Pisa, Italy

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Asta Försti Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany

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Kari Hemminki Biomedical Center, Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Pilsen, Czech Republic
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

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Rossella Elisei Department of Endocrinology, University Hospital, Pisa, Italy

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Cristina Romei Department of Endocrinology, University Hospital, Pisa, Italy

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Eric Adriano Zizzi PolitoBIO Med Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy

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Marco Agostino Deriu PolitoBIO Med Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy

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Manuela Simoni Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy

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Stefano Landi Department of Biology, University of Pisa, Pisa, Italy

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Livio Casarini Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy

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cancer with increasing incidence in the last 20 years, likely because of the increased knowledge of associated risk factors and ameliorated diagnostic procedures ( 2 ). However, most DTC have a favourable prognosis ( 3 ), and the diagnostic

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