Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Search for other papers by Ayanthi Wijewardene in
Google Scholar
PubMed
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Search for other papers by Matti Gild in
Google Scholar
PubMed
Search for other papers by Carolina Nylén in
Google Scholar
PubMed
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
Search for other papers by Geoffrey Schembri in
Google Scholar
PubMed
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
Search for other papers by Paul Roach in
Google Scholar
PubMed
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
Search for other papers by Jeremy Hoang in
Google Scholar
PubMed
Search for other papers by Ahmad Aniss in
Google Scholar
PubMed
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
Search for other papers by Anthony Glover in
Google Scholar
PubMed
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
Search for other papers by Mark Sywak in
Google Scholar
PubMed
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
Search for other papers by Stan Sidhu in
Google Scholar
PubMed
Search for other papers by Diana Learoyd in
Google Scholar
PubMed
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Search for other papers by Bruce Robinson in
Google Scholar
PubMed
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Search for other papers by Lyndal Tacon in
Google Scholar
PubMed
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Search for other papers by Roderick Clifton-Bligh in
Google Scholar
PubMed
thyroidectomy for differentiated thyroid cancer for 3 reasons: to ablate remnant thyroid tissue in low-risk patients; prevent recurrent disease in high-risk patients (adjuvant therapy); or to treat residual or metastatic disease [ 5 ]. Clinical paradigms have
Medical School, University of Milan, Milan, Italy
Search for other papers by Stamatina Ioakim in
Google Scholar
PubMed
Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
Search for other papers by Akheel A Syed in
Google Scholar
PubMed
Search for other papers by George Zavros in
Google Scholar
PubMed
Search for other papers by Michalis Picolos in
Google Scholar
PubMed
Department of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Search for other papers by Luca Persani in
Google Scholar
PubMed
Department of Diabetes, Endocrinology & Obesity Medicine, Salford Royal NHS Foundation & University Teaching Trust, Salford, UK
Medical School, European University of Cyprus, Nicosia, Cyprus
Search for other papers by Angelos Kyriacou in
Google Scholar
PubMed
). Reassuringly, a recent long-term study of a 17,500-patient cohort with nodules greater than 10 mm in size showed an even lower risk of malignancy at 1.1% ( 6 ). The latter study differed from previous studies in that there was less selection bias and papillary
Search for other papers by Line Tang Møllehave in
Google Scholar
PubMed
Search for other papers by Nils Knudsen in
Google Scholar
PubMed
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Search for other papers by Allan Linneberg in
Google Scholar
PubMed
Search for other papers by Inge Bülow Pedersen in
Google Scholar
PubMed
Search for other papers by Gitte Ravn-Haren in
Google Scholar
PubMed
Search for other papers by Anja Lykke Madsen in
Google Scholar
PubMed
Search for other papers by Allan Carlé in
Google Scholar
PubMed
Search for other papers by Charlotte Cerqueira in
Google Scholar
PubMed
Search for other papers by Anne Krejbjerg in
Google Scholar
PubMed
Search for other papers by Lone Banke Rasmussen in
Google Scholar
PubMed
Search for other papers by Lars Ovesen in
Google Scholar
PubMed
Search for other papers by Hans Perrild in
Google Scholar
PubMed
Department of Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark
Search for other papers by Lena Bjergved Sigurd in
Google Scholar
PubMed
Search for other papers by Betina Heinsbæk Thuesen in
Google Scholar
PubMed
Search for other papers by Pernille Vejbjerg in
Google Scholar
PubMed
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Search for other papers by Torben Jørgensen in
Google Scholar
PubMed
optimal thyroid health in the population. Both iodine deficiency (ID) and iodine excess are associated with an increased risk of thyroid disease, and the optimal distribution of the population’s iodine intake lies within a narrow range. Therefore, the
Search for other papers by Furio Pacini in
Google Scholar
PubMed
Search for other papers by Dagmar Fuhrer in
Google Scholar
PubMed
Search for other papers by Rossella Elisei in
Google Scholar
PubMed
Search for other papers by Daria Handkiewicz-Junak in
Google Scholar
PubMed
Search for other papers by Sophie Leboulleux in
Google Scholar
PubMed
Search for other papers by Markus Luster in
Google Scholar
PubMed
Search for other papers by Martin Schlumberger in
Google Scholar
PubMed
Search for other papers by Johannes W Smit in
Google Scholar
PubMed
frequently even undetectable serum thyroglobulin (Tg) levels (at least in the hands of large volume surgeons) on levothyroxine (LT4) treatment. In these cases, particularly in low-risk patients, the goal of remnant ablation is already achieved following the
Search for other papers by Aly Bernard Khalil in
Google Scholar
PubMed
Search for other papers by Roberto Dina in
Google Scholar
PubMed
Search for other papers by Karim Meeran in
Google Scholar
PubMed
Search for other papers by Ali M. Bakir in
Google Scholar
PubMed
Search for other papers by Saf Naqvi in
Google Scholar
PubMed
Search for other papers by Alia Al Tikritti in
Google Scholar
PubMed
Search for other papers by Nader Lessan in
Google Scholar
PubMed
Search for other papers by Maha T. Barakat in
Google Scholar
PubMed
” diagnosis or Thy3 [ 8 , 9 ]. The reported risk of malignancy in this group is variable among different centers, ranging from 6 to 48% [ 10 ]. In this regard, the role of ultrasound has emerged as a practical and accurate tool in the risk stratification of
Search for other papers by Nicholas S. Andresen in
Google Scholar
PubMed
Search for other papers by John M. Buatti in
Google Scholar
PubMed
Search for other papers by Hamed H. Tewfik in
Google Scholar
PubMed
Search for other papers by Nitin A. Pagedar in
Google Scholar
PubMed
Search for other papers by Carryn M. Anderson in
Google Scholar
PubMed
Search for other papers by John M. Watkins in
Google Scholar
PubMed
of curative-intent therapy, though in selected lower-risk cases, subtotal thyroidectomy or ultrasound-based surveillance may be considered [ 4 - 6 ]. When total thyroidectomy is performed, many patients with differentiated thyroid cancer are treated
Search for other papers by Jan Debeij in
Google Scholar
PubMed
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Search for other papers by Suzanne C. Cannegieter in
Google Scholar
PubMed
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
Search for other papers by Bregje van Zaane in
Google Scholar
PubMed
Search for other papers by Anton P. van Zanten in
Google Scholar
PubMed
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden
Search for other papers by Frits R. Rosendaal in
Google Scholar
PubMed
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
Search for other papers by Victor E.A. Gerdes in
Google Scholar
PubMed
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden
Search for other papers by Pieter H. Reitsma in
Google Scholar
PubMed
Departments of Endocrinology and Metabolism, Leiden University Medical Centre, Leiden
Search for other papers by Olaf M. Dekkers in
Google Scholar
PubMed
fibrillation. Haemorrhage is an important complication of anticoagulant treatment. Annually, 7-10% of patients treated with VKA suffer from haemorrhage, and 1-3% from major haemorrhage [ 1 , 2 ]. Several risk factors for a bleeding tendency have been identified
Search for other papers by Bernadette Biondi in
Google Scholar
PubMed
Search for other papers by Luigi Bartalena in
Google Scholar
PubMed
Search for other papers by David S. Cooper in
Google Scholar
PubMed
Search for other papers by Laszlo Hegedüs in
Google Scholar
PubMed
Search for other papers by Peter Laurberg in
Google Scholar
PubMed
Search for other papers by George J. Kahaly in
Google Scholar
PubMed
strong recommendation (for or against) because the benefits outweighed the risks (or vice versa). Level 2 was a weak recommendation (for or against) in which the treatment depended on the patient's preference because the benefits and risks were uncertain
Search for other papers by Enrique Soto-Pedre in
Google Scholar
PubMed
Search for other papers by Moneeza K. Siddiqui in
Google Scholar
PubMed
Search for other papers by Ify Mordi in
Google Scholar
PubMed
Search for other papers by Cyrielle Maroteau in
Google Scholar
PubMed
Search for other papers by Jimena Soto-Hernaez in
Google Scholar
PubMed
Search for other papers by Colin N.A. Palmer in
Google Scholar
PubMed
Search for other papers by Ewan R. Pearson in
Google Scholar
PubMed
Department of Endocrinology and Diabetes, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
Search for other papers by Graham P. Leese in
Google Scholar
PubMed
-related disorders. A recent meta-analysis of GWAS for thyroid function and dysfunction, testing up to 8 million genetic variants, developed a TSH-based genetic risk score (GRS) and reported its association with hypothyroidism, hyperthyroidism, and other endpoints
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria, Modena, Italy
Search for other papers by Giulia Brigante in
Google Scholar
PubMed
Search for other papers by Clara Lazzaretti in
Google Scholar
PubMed
Search for other papers by Elia Paradiso in
Google Scholar
PubMed
Search for other papers by Federico Nuzzo in
Google Scholar
PubMed
Search for other papers by Martina Sitti in
Google Scholar
PubMed
Search for other papers by Frank Tüttelmann in
Google Scholar
PubMed
Search for other papers by Gabriele Moretti in
Google Scholar
PubMed
Search for other papers by Roberto Silvestri in
Google Scholar
PubMed
Search for other papers by Federica Gemignani in
Google Scholar
PubMed
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany
Search for other papers by Asta Försti in
Google Scholar
PubMed
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Search for other papers by Kari Hemminki in
Google Scholar
PubMed
Search for other papers by Rossella Elisei in
Google Scholar
PubMed
Search for other papers by Cristina Romei in
Google Scholar
PubMed
Search for other papers by Eric Adriano Zizzi in
Google Scholar
PubMed
Search for other papers by Marco Agostino Deriu in
Google Scholar
PubMed
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
Search for other papers by Manuela Simoni in
Google Scholar
PubMed
Search for other papers by Stefano Landi in
Google Scholar
PubMed
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
Search for other papers by Livio Casarini in
Google Scholar
PubMed
cancer with increasing incidence in the last 20 years, likely because of the increased knowledge of associated risk factors and ameliorated diagnostic procedures ( 2 ). However, most DTC have a favourable prognosis ( 3 ), and the diagnostic