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Introduction Radioactive iodine (RAI) has been used for the treatment of patients with Graves’ hyperthyroidism since the 1950s. After a single RAI administration, patients ideally become euthyroid but frequently develop hypothyroidism. On the
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Dear Editor, Insufficient iodine nutrition is still an existing problem in some European countries [ 1 ]; however, the incidence of iodine deficiency has decreased during the last few decades. To prevent endemic goiter, a national iodization
Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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radiation, thermal ablation, and cement injections [ 10 - 12 ]. Although rarely curative, radioactive iodine therapy (RAI) is recommended for all patients with bone metastases and may benefit individuals with RAI avid bone lesions. However, there is no
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Dear Editor, We read the article ‘Relative impact of iodine supplementation and maternal smoking on cord blood thyroglobulin in pregnant women with normal thyroid function' by Hiéronimus et al. [ 1 ] with great interest. The authors
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Objectives: When exposed to iodine contrast medium (ICM), thyroid dysfunction may develop, due to excess amounts of iodide. The incidence of contrast-induced thyroid dysfunction has been difficult to interpret, because of the observational and retrospective designs of most previous studies. With the Swedish CArdioPulmonary bioImage Study (SCAPIS), where randomly selected individuals aged 50–65 years, underwent contrast-enhanced coronary CT angiography (CCTA), we were able to prospectively assess the incidence, magnitude and clinical impact of contrast-induced thyroid dysfunction.
Methods: In 422 individuals, thyroid hormone levels were analysed before and 4–12 weeks after CCTA. Thyroid-related patient-reported outcome questionnaires (ThyPRO) at the time of pre and post CCTA blood samplings were provided by 368 of those individuals. Thyroid peroxidase antibodies (TPOab) were analysed and ultrasound of the thyroid gland was performed to detect any thyroid nodules.
Results: There was a small statistically significant effect on thyroid hormone levels but no cases of overt hypo- or hyperthyroidism after ICM. Subclinical hypo- or hyperthyroidism or isolated low/high levels of free thyroxine (fT4) developed in 3.5% of the population with normal hormone levels pre-CCTA, but without any increased thyroid-related symptoms compared to the remaining cohort. Elevated TPOab and being born outside Sweden were risk factors of developing subclinical hypothyroidism. Presence of thyroid nodules was not associated with ICM-induced thyroid dysfunction.
Conclusion: The results of this prospective study support the notion that in iodine-sufficient countries, ICM associated thyroid dysfunction is rare, usually mild, self-limiting and oligo/asymptomatic in subjects aged 50–65 years.
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The initial treatment of differentiated thyroid cancer consists of total or near-total thyroidectomy. Surgery is usually followed by the administration of radioactive iodine activities (RAI) aimed to ablate any remnant thyroid tissue and
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Insights Lymphadenitis can occur in association with RAI therapy for Graves’ disease. This can progress to abscess formation requiring surgical drainage. Introduction The use of radioactive iodine or iodine-131 (I-131) in the
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. According to current guidelines, preoperative treatment of (refractory) hyperthyroidism consists of the administration of a thionamide (e.g., methimazole), beta-blocker, glucocorticoid, and an iodine-containing preparation [ 1 ]. These treatment protocols
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Dear Sir, Five months after radioactive iodine treatment for Graves’ hyperthyroidism, I developed severe hypothyroidism. Three months after treatment, TSH, FT4 and FT3 values were within reference range (0.44 mlU/l, 15.9 and 4.5 pmol
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calculated low risk of recurrence of multifocal papillary thyroid microcarcinoma after total thyroidectomy, routine radioactive iodine (RAI) ablation is not recommended and close surveillance is advocated [ 10 ]. In the updated 2015 American Thyroid