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report found a microcarcinoma (papillary carcinoma ≤1 cm in diameter) associated with a TIR-2-cytological report, we considered it to be FN only if the area of the FNA included the area in which the cytopathologist found the carcinoma. Results
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United States, 1973-2002. JAMA 2006;295:2164-2167. 6 Rossing M, Nygaard B, Nielsen FC, Bennedbæk FN: High prevalence of papillary thyroid microcarcinoma in Danish patients: a prospective study of 854 consecutive patients with a cold thyroid nodule
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presentation of Cowden syndrome patients to general and endocrine surgeons. Multiple mutations are known to be associated with papillary thyroid cancer, including the RET / PTC and BRAF mutations [ 5 , 6 ]. Cowden syndrome-associated malignancies occur
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.1–65.1 pg/mL). Among these, the histological diagnoses were: follicular hyperplasia ( n = 1), follicular adenoma ( n = 1), papillary thyroid carcinoma ( n = 4, 2 microcarcinomas), and follicular carcinoma ( n = 2). The high prevalence of malignancy in
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Leboulleux S , Tuttle RM , Pacini F , Schlumberger M . Papillary thyroid microcarcinoma: time to shift from surgery to active surveillance? lancet Diabetes Endocrinol. 2016 Nov;4(11):933–42. 17
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Istituto Oncologico del Mediterraneo, Viagrande, Italy
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Istituto Oncologico del Mediterraneo, Viagrande, Italy
Department of Surgery, McGill University, St. Mary Hospital, Montreal, Québec, Canada
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found that this test was able to distinguish malignant from benign lesions with a sensitivity of 92.3%. There was only 1 patient in our study group (case ZA; multifocal papillary thyroid microcarcinoma [PTMC] with a lymph node positive for
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) intrathyroidal papillary microcarcinomas that are either BRAF WT or BRAF mutated (if known). Finally, minimal extrathyroidal extension appears to have little impact on outcome and in the 2017 TNM classification for the risk of thyroid cancer related death is no
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of incidental papillary thyroid microcarcinoma (PTmC) in the background. The presence of incidental PTmC was considered under ‘benign’ on resection as this area may not have been sampled during the FNA procedure. Molecular analysis, if performed, was
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, Wei SF, Li DS, Zhu QH, Sun SJ, Li M, Li LI: Outcome of papillary thyroid microcarcinoma: study of 1,990 cases. Mol Clin Oncol 2015; 3:672–676. 10.3892/mco.2015.495 26137285 9 Noda S, Onoda N, Morisaki T, Kashiwagi S, Takashima T, Hirakawa K
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Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy
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Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy
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thyroid cancer. Thyroid 2015; 25: 221–228. 26 Hay ID, Hutchinson ME, Gonzalez-Losada T, McIver B, Reinalda ME, Grant CS, Thompson GB, Sebo TJ, Goellner JR: Papillary thyroid microcarcinoma: a study of 900 cases observed in a 60-year period. Surgery