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Laszlo Hegedüs
Laszlo Hegedüs
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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Andrea Frasoldati
Andrea Frasoldati
Division of Endocrinology, Arcispedale S. Maria Nuova, Reggio Emilia, Italy
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Roberto Negro
Roberto Negro
Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy
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Enrico Papini
Enrico Papini
Division of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy
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disease, is well accepted [ 1 - 3 ]. Fine needle aspiration (FNA) and, to a lesser extent, core needle biopsy (CNB), are currently recognized as the primary diagnostic methods for evaluating thyroid lesions, cervical lymph-node metastases and local
Marko Stojanović
Marko Stojanović
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Sandra Pekić
Sandra Pekić
Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Mirjana Doknić
Mirjana Doknić
Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Dragana Miljić
Dragana Miljić
Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Slavica Ćirić
Slavica Ćirić
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Aleksandar Diklić
Aleksandar Diklić
Faculty of Medicine, University of Belgrade
Endocrine Surgery Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Endocrine Surgery Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Svetislav Tatić
Svetislav Tatić
Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Miloje Joksimović
Miloje Joksimović
Clinic for Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia
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Emilija Manojlović-Gačić
Emilija Manojlović-Gačić
Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Milica Skender-Gazibara
Milica Skender-Gazibara
Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Vera Popović
Vera Popović
Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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, CITED and others. Metastatic lesions from PTC most frequently involve the regional lymph nodes, resulting in a higher local recurrence incidence but not altering the overall prognosis except in older patients. Distant metastases are rare, occurring in
Carla Gambale
Carla Gambale
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Alessandro Prete
Alessandro Prete
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Lea Contartese
Lea Contartese
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Liborio Torregrossa
Liborio Torregrossa
Department of Surgical, Medical, Molecular Pathology and Critical Area, Anatomic Pathology Section, University Hospital of Pisa, Pisa, Italy
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Francesca Bianchi
Francesca Bianchi
Department of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Gabriele Materazzi
Gabriele Materazzi
Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Endocrine Surgery, University Hospital of Pisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Antonio Matrone
Antonio Matrone
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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; CV-PTC, classical variant papillary thyroid carcinoma; FTC, follicular thyroid carcinoma; FV-PTC, follicular variant papillary thyroid carcinoma; LCND, latero-cervical compartment lymph node dissection; mETE, minimal extrathyroidal extension
Eun Kyung Jang
Eun Kyung Jang
Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea
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Dong Eun Song
Dong Eun Song
Departments of Pathology, University of Ulsan College of Medicine, Seoul, South Korea
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Gyungyub Gong
Gyungyub Gong
Departments of Pathology, University of Ulsan College of Medicine, Seoul, South Korea
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Jung Hwan Baek
Jung Hwan Baek
Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
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Yun Mi Choi
Yun Mi Choi
Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea
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Min Ji Jeon
Min Ji Jeon
Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea
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Ji Min Han
Ji Min Han
Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea
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Won Gu Kim
Won Gu Kim
Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea
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Tae Yong Kim
Tae Yong Kim
Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea
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Young Kee Shong
Young Kee Shong
Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea
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Won Bae Kim
Won Bae Kim
Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, South Korea
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cytologic findings and a negative histological diagnosis of PTC in the thyroid. They evaluated cytological samples, surgically removed thyroid, and cervical lymph nodes (LNs) twice to scrutinize all samples for missing malignancy or other thyroid pathologies
Alessia Cozzolino
Alessia Cozzolino
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Tiziana Filardi
Tiziana Filardi
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Ilaria Simonelli
Ilaria Simonelli
Service of Medical Statistics and Information Technology, Fatebenefratelli Foundation for Health Research and Education, Rome, Italy
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
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Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
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Giorgio Grani
Giorgio Grani
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Camilla Virili
Camilla Virili
Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy
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Ilaria Stramazzo
Ilaria Stramazzo
Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy
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Maria Giulia Santaguida
Maria Giulia Santaguida
Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy
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Pietro Locantore
Pietro Locantore
Endocrinology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
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Massimo Maurici
Massimo Maurici
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
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Daniele Gianfrilli
Daniele Gianfrilli
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Andrea M Isidori
Andrea M Isidori
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Carlotta Pozza
Carlotta Pozza
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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on behalf of TALENT Group
on behalf of TALENT Group
on behalf of TALENT Group
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calcifications and enlarged cervical lymph nodes were the US features with the highest likelihood ratio for thyroid cancer, being a cystic composition suggestive of benign nodules ( 6 ). Furthermore, a recent meta-analysis evaluated the performance of adult based
Vittoria Guarda
Vittoria Guarda
Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany
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Anja Pickhard
Anja Pickhard
Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany
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Melanie Boxberg
Melanie Boxberg
Institute of Pathology, Technical University of Munich, Munich, Germany
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Katja Specht
Katja Specht
Institute of Pathology, Technical University of Munich, Munich, Germany
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Anna Maria Stefanie Buchberger
Anna Maria Stefanie Buchberger
Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany
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, and the common carotid artery. No lymph node metastasis was seen at the time of diagnosis in all cases, but distant metastases occurred in 4 patients. The lung was the most frequent site ( n = 4), followed by the bones ( n = 3), skin ( n = 2), and
Matthieu Bosset
Matthieu Bosset
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Maxime Bonjour
Maxime Bonjour
Service de Biostatistique, Hospices Civils de Lyon, Lyon, France
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Solène Castellnou
Solène Castellnou
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Zakia Hafdi-Nejjari
Zakia Hafdi-Nejjari
Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Claire Bournaud-Salinas
Claire Bournaud-Salinas
Centre de Médecine Nucléaire, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Myriam Decaussin-Petrucci
Myriam Decaussin-Petrucci
Service d’Anatomie-Pathologique, Hospices Civils de Lyon, Groupement Hospitalier Lyon-Sud, Pierre Bénite, France
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Jean Christophe Lifante
Jean Christophe Lifante
Service de Chirurgie Endocrinienne, Hospices Civils de Lyon, Groupement Hospitalier Lyon-Sud, Pierre Bénite, France
Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France
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Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France
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Agnès Perrin
Agnès Perrin
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Jean-Louis Peix
Jean-Louis Peix
Service de Chirurgie Endocrinienne, Hospices Civils de Lyon, Groupement Hospitalier Lyon-Sud, Pierre Bénite, France
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Philippe Moulin
Philippe Moulin
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
CarMeN Laboratory, Université Claude-Bernard Lyon 1, Inserm U1060, INRA U1397, INSA Lyon, IMBL, Villeurbanne, France
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CarMeN Laboratory, Université Claude-Bernard Lyon 1, Inserm U1060, INRA U1397, INSA Lyon, IMBL, Villeurbanne, France
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Geneviève Sassolas
Geneviève Sassolas
Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Michel Pugeat
Michel Pugeat
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
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Françoise Borson-Chazot
Françoise Borson-Chazot
Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France
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Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France
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stable in the absence of plasma concentration doubling within 2 years. Reoperations were performed if thyroid nodules or cervical lymph nodes were discovered or increased in size, along with a suspicious ultrasound result and positive or suspicious fine
João Roque
João Roque
Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal
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Tiago Nunes Silva
Tiago Nunes Silva
Endocrinology, Diabetes and Metabolism Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
NOVA Medical School | Faculdade de Ciências Médicas of Universidade NOVA de Lisboa, Lisbon, Portugal
Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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NOVA Medical School | Faculdade de Ciências Médicas of Universidade NOVA de Lisboa, Lisbon, Portugal
Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Catarina Regala
Catarina Regala
Endocrinology, Diabetes and Metabolism Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Ricardo Rodrigues
Ricardo Rodrigues
Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Endocrinology, Diabetes and Metabolism Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
NOVA Medical School | Faculdade de Ciências Médicas of Universidade NOVA de Lisboa, Lisbon, Portugal
Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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NOVA Medical School | Faculdade de Ciências Médicas of Universidade NOVA de Lisboa, Lisbon, Portugal
Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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-regional metastasis was present in four (50%) and distant metastasis was present in seven (87.5%) patients at lenvatinib start, particularly in mediastinal lymph nodes (six patients), lung (five patients), and bone (five patients). Table 2 Baseline
Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Laszlo Hegedüs
Laszlo Hegedüs
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Agnieszka Czarniecka
Agnieszka Czarniecka
M. Sklodowska-Curie National Research, Institute of Oncology Gliwice Branch, Gliwice, Poland
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Ralf Paschke
Ralf Paschke
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Gilles Russ
Gilles Russ
Thyroid and Endocrine Tumors Department, Pitié-Salpêtrière Hospital, Sorbonne University GRC N°16, Paris, France
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Fernando Schmitt
Fernando Schmitt
Faculty of Medicine of University of Porto, CINTESIS@RISE and Institute of Molecular Pathology and Immunology, University of Porto (Ipatimup), Porto, Portugal
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Paula Soares
Paula Soares
Institute of Investigation and Innovation in Health (I3S), Faculty of Medicine of the University of Porto, Porto, Portugal
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Tamas Solymosi
Tamas Solymosi
Endocrinology and Metabolism Clinic, Bugat Hospital, Gyöngyös, Hungary
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Enrico Papini
Enrico Papini
Department of Endocrine and Metabolic Diseases, Regina Apostolorum Hospital, Albano, Rome, Italy
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. ( https://doi.org/10.3390/cancers14010204 ) 80 Li Q Liu Y Zhang G Long H Jiang Y & Su X . Diagnostic strategy of fine needle aspiration cytology of cystic cervical lymph node metastasis from papillary thyroid carcinoma . Diagnostic
Zhaoqi Zhang
Zhaoqi Zhang
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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Josef Yu
Josef Yu
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Eva Rainer
Eva Rainer
Department of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Vienna, Austria
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Lindsay Hargitai
Lindsay Hargitai
Department of General Surgery, Medical University of Vienna, Vienna, Austria
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Zewen Jiang
Zewen Jiang
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Georgios Karanikas
Georgios Karanikas
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Tatjana Traub-Weidinger
Tatjana Traub-Weidinger
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Richard Crevenna
Richard Crevenna
Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Vienna, Austria.
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Marcus Hacker
Marcus Hacker
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Shuren Li
Shuren Li
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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negative lesions were mainly observed in pulmonary nodules and cervical lymph nodes smaller than 1 cm. The detail lesion-related diagnostic values of [ 18 F]F-DOPA PET/CT in females and males, PMTC and RMTC, HMTC and SMTC, are shown in Table 1 . Cut
