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Aamna Hassan Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Saima Riaz Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Humayun Bashir Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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M. Khalid Nawaz Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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Raza Hussain Departments of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

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difference in treatment was made based on size. Furthermore, empirical RAI therapy was initially given to all patients with elevated Tg levels, even when no iodine avid disease was seen on the pretherapy scan. Our center did not have a PET/CT scanner before

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Flora Veltri Department of Endocrinology, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Kris Poppe Department of Endocrinology, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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urinary iodine (100–149 ug/L) had median serum TSH and FT4 levels comparable with those in the reference group (urinary iodine between 150 and 249 µg/L) [ 21 ]. Also, in a study performed in Belgium (an area with a moderate ID), serum TSH concentrations

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Victor J M Pop Department of Medical Psychology, Tilburg University, The Netherlands

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Johannes G Krabbe Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Medlon BV, Enschede, The Netherlands

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Maarten Broeren Department of Clinical Chemistry, Maxima Medical Centre, Veldhoven, The Netherlands

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Wilmar Wiersinga Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands

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Margaret P Rayman Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

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case in pregnancy ( 29 ). Another study from Amsterdam in pregnant women in an iodine replete area showed that with increasing term, plasma FT4 and FT3 concentrations decreased with a concomitant increase of free rT3 levels, changes that are also found

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Luigi Bartalena Department of Medicine and Surgery, University of Insubria, Varese, Italy

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Fausto Bogazzi Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Luca Chiovato Unit of Internal Medicine and Endocrinology, Istituti Clinici Scientifici Maugeri and University of Pavia, Pavia, Italy

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Alicja Hubalewska-Dydejczyk Department of Endocrinology, Jagiellonian University Medical College, Cracow, Poland

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Thera P. Links Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Mark Vanderpump Physicians’ Clinic, London, United Kingdom

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from the Wolff-Chaikoff effect [ 10 ], resulting in a normalization of T 4 and TSH serum concentrations. In this phase, serum total T 4 (TT 4 ), free T 4 (FT 4 ), and reverse T 3 (rT 3 ) levels increase, while serum total T 3 (TT 3 ) and free T 3

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R. Burns UCD School of Medicine and Medical Science, University College Dublin

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C. O'Herlihy UCD School of Medicine and Medical Science, University College Dublin
National Maternity Hospital, Dublin, Ireland

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P.P.A. Smyth UCD School of Medicine and Medical Science, University College Dublin

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iodine intake to ensure sufficient iodide for normal fetal development. Previous studies by our group have shown similar levels of iodide uptake in placenta to that of thyroid and have identified a previously unreported capacity of the placenta to store

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Tomasz Bednarczuk Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland

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Thomas H. Brix Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Wolfgang Schima Department of Diagnostic and Interventional Radiology, Goettlicher Heiland Krankenhaus, Barmherzige Schwestern Krankenhaus, and Sankt Josef Krankenhaus, Vienna, Austria

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Georg Zettinig Schilddruesenpraxis Josefstadt, Vienna, Austria

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George J. Kahaly Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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thyroid gland remain poorly characterized. It is generally accepted that ICM can cause thyroid dysfunction (TD) because of supraphysiological concentrations of iodine in the contrast solution [ 2 - 5 ]. While the normal thyroid gland can usually adapt to

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Tania Pilli Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Silvia Cantara Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Lutz Schomburg Institute of Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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Valeria Cenci Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Sandro Cardinale Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Ellen C.D. Heid Institute of Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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Eike C. Kühn Institute of Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Berlin, Germany

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Gabriele Cevenini Department of Medical Biotechnologies, University of Siena, Siena, Italy

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Fausta Sestini Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Carla Fioravanti Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Gabriele D'Hauw Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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Furio Pacini Section of Endocrinology, Department of Medicine, Surgery and Neuroscience, Siena, Italy

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serum selenium concentration was 81.8 ± 14.6 μg/l (median = 83; range = 32-112) and was consistent with the values reported in Europeans [ 23 ]. Thyroid echogenicity, measured as mean gray-scale pixel value (89.8 ± 16.9), was consistent with the levels

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Theodora Pappa Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital

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Maria Alevizaki Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital
Department of Endocrinology, Metabolism and Diabetes, Evgenideion Hospital, Athens University School of Medicine, Athens, Greece

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hypothyroidism; metformin treatment led to a significant reduction of TSH levels that was reversed when metformin was discontinued, whereas TH levels were unaltered. Interestingly, the degree of TSH reduction was associated with baseline TSH concentration. Since

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Berta Soldevila Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain

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Inés Velasco Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Obstetrics & Gynecology, Germans Trias i Pujol University Hospital, Badalona, Spain

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Carla Muñoz Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain

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Yesika Díaz Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain

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Laia Egea-Cortés Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain

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Laura Ferrer-Escopiñan Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain

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Alejandra Pérez-Montes de Oca Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain

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Raquel Martínez-Mondejar Department of Obstetrics & Gynecology, Germans Trias i Pujol University Hospital, Badalona, Spain

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Jordi Casabona Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain

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Manel Puig-Domingo Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain

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intra-analysis CVs were <5.9%. The reference range for the general population is <4.11 IU/mL. Urine fluid iodine concentrations were measured following the Benotti technique ( 10 ). Statistical analyses Multiple imputation algorithms were used to

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Kathrin A. Schmohl Department of Internal Medicine II, Germany

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Andrea M. Müller Department of Internal Medicine II, Germany

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Nathalie Schwenk Department of Internal Medicine II, Germany

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Kerstin Knoop Department of Internal Medicine II, Germany

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Eddy Rijntjes Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Heike Heuer Leibniz Institute for Environmental Medicine, Düsseldorf, Germany

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Peter Bartenstein Department of Nuclear Medicine, Germany

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Burkhard Göke Department of Internal Medicine II, Germany

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Peter J. Nelson Medical Policlinic IV, University Hospital of Munich, Munich, Germany

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Christine Spitzweg Department of Internal Medicine II, Germany

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) in the presence or absence of stimulation of thyroidal iodide uptake by treatment with a low-iodine diet (LID) for 1-4 weeks or exogenous thyroid-stimulating hormone (TSH) application prior to the administration of radioiodide [ 3 , 4 , 5 , 6 , 7 , 8

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