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Ana Isabel Álvarez-Mancha Department of Medicine, University of Malaga, Malaga, Spain
Department of Pathology, General University Hospital of Ciudad Real, Ciudad Real, Spain

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Isabel Mancha-Doblas Department of Medicine, University of Malaga, Malaga, Spain
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain

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María Molina-Vega Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain
The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, Malaga, Spain

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Diego Fernández-García Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain

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Ana María Gómez-Pérez Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain
The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, Malaga, Spain

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Elena Gallego-Domínguez Department of Medicine, University of Malaga, Malaga, Spain
Department of Pathology, Virgen de la Victoria University Hospital, Málaga, Spain

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María Victoria Ortega-Jiménez Department of Medicine, University of Malaga, Malaga, Spain
Department of Pathology, Virgen de la Victoria University Hospital, Málaga, Spain

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Isabel Hierro-Martín Department of Pathology, Virgen de la Victoria University Hospital, Málaga, Spain

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Francisco J Tinahones Department of Medicine, University of Malaga, Malaga, Spain
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain
The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, Malaga, Spain

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Introduction Clinical management of the thyroid nodules is based on a combination of clinical risk factors, functional status, ultrasound patterns, and cytologic findings when fine needle aspiration (FNA) is indicated ( 1 , 2 , 3 , 4 , 5

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Stamatina Ioakim CEDM, Centre of Endocrinology, Diabetes & Metabolism, Limassol, Cyprus
Medical School, University of Milan, Milan, Italy

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Akheel A Syed Department of Diabetes, Endocrinology & Obesity Medicine, Salford Royal NHS Foundation & University Teaching Trust, Salford, UK
Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

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George Zavros CEDM, Centre of Endocrinology, Diabetes & Metabolism, Limassol, Cyprus

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Michalis Picolos Alithias Endocrinology Centre, Nicosia, Cyprus

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Luca Persani Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
Department of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Angelos Kyriacou CEDM, Centre of Endocrinology, Diabetes & Metabolism, Limassol, Cyprus
Department of Diabetes, Endocrinology & Obesity Medicine, Salford Royal NHS Foundation & University Teaching Trust, Salford, UK
Medical School, European University of Cyprus, Nicosia, Cyprus

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Introduction Epidemiological studies suggest that approximately 50–70% of adults in the general public and across different geographic locations harbour thyroid nodules if examined by thyroid ultrasound scan (USS), while 20% have a nodule that

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Aglaia Kyrilli Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Nunzia Tacelli Department of Radiology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Lucia Russo Department of Medicine, DIMED, Internal Medicine 3, University of Padua, Via Giustiniani 2, 35128, Padova, Italy

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Laetitia Lebrun Department of Pathology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Isabelle Salmon Department of Pathology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Gilles Russ Thyroid and Endocrine Tumors, Institute of Endocrinology, Pitié Salpêtrière Hospital, Pierre et Marie Curie University, Paris, France

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Rodrigo Moreno-Reyes Department of Nuclear Medicine, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik, Brussels, Belgium

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Bernard Corvilain Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Introduction Thyroid nodules are a very frequent problem in routine clinical practice ( 1 , 2 ). In regions with past or current iodine insufficiency, such as many European countries, the prevalence of autonomously functioning thyroid nodules

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Mohamed Abdouh Cancer Research Program, McGill University Health Centre-Research Institute, Montreal, Québec, Canada

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Roger Tabah Department of Surgery and Department of Oncology, McGill University Health Centre, Montreal, Québec, Canada

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Vincenzo Arena Department of Obstetrics and Gynecology, Santo Bambino Hospital, Catania, Italy

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Manuel Arena Fondazione Istituto G. Giglio Cefalù, Pisciotto, Italy

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Zu-hua Gao Department of Pathology, McGill University Health Centre-Research Institute, Montreal, Québec, Canada

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Aurelio Lorico College of Medicine, Touro University Nevada, Henderson, Nevada, USA
Istituto Oncologico del Mediterraneo, Viagrande, Italy

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Goffredo Orazio Arena Fondazione Istituto G. Giglio Cefalù, Pisciotto, Italy
Istituto Oncologico del Mediterraneo, Viagrande, Italy
Department of Surgery, McGill University, St. Mary Hospital, Montreal, Québec, Canada

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. There is a rise in the incidence of salivary gland cancers; this group accounted for 6.3% of all head and neck cancers in 1974–1976, as compared to 8.1% in 1998–1999 [ 1 ]. The propensity of the thyroid gland to form nodules is demonstrated by the

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Roberto Negro Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy

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Pierpaolo Trimboli Clinic for Nuclear Medicine and Competence Center for Thyroid Diseases, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland

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In the present issue of European Thyroid Journal , Papini et al. [ 1 ] published guidelines for the use of thermal ablation (TA) in benign thyroid nodules, sponsored by the European Thyroid Association (ETA). The guidelines highlight the state

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Dong Gyu Na Department of Radiology, Human Medical Imaging and Intervention Center, Seoul, South Korea

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Hye Sook Min Departments of Pathology, Seoul, South Korea

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Hunkyung Lee Department of Pathology, Ewha Clinical Laboratory, Seoul, South Korea

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Jae-Kyung Won Departments of Pathology, Seoul, South Korea

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Hyo Bin Seo Department of Radiology, Seoul National University Hospital Kangnam Center, Seoul, South Korea

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Ji-Hoon Kim Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea

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Introduction The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) recommends repeat fine-needle aspiration (RFNA) for thyroid nodules initially diagnosed as atypia/follicular lesion of undetermined significance (AUS/FLUS) [ 1 , 2

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Pedro Weslley Souza Rosario Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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corresponding nodules ≤1 cm could be postponed until therapy is considered. This is the recommendation of the European Thyroid Association (ETA) [ 1 ] and American Thyroid Association (ATA) [ 2 ]. Although I agree that active surveillance is an option for low

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Cléber P. Camacho Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Susan C. Lindsey Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Teresa S. Kasamatsu Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Alberto L. Machado Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil

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João Roberto M. Martins Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Rosa Paula M. Biscolla Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil

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Magnus R. Dias da Silva Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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José Gilberto H. Vieira Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil

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Rui M.B. Maciel Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil

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concentration of calcitonin at which a hook effect may be observed. In the 42 washouts performed on thyroid nodules, 6 subjects with benign cytology had calcitonin concentrations <2.2 pg/ml, and 4 of the 6 subjects with calcitonin levels >1,600 pg/ml were

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Alessia Cozzolino Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Tiziana Filardi Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Ilaria Simonelli Service of Medical Statistics and Information Technology, Fatebenefratelli Foundation for Health Research and Education, Rome, Italy
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Giorgio Grani Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Camilla Virili Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy

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Ilaria Stramazzo Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy

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Maria Giulia Santaguida Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy

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Pietro Locantore Endocrinology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy

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Massimo Maurici Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Daniele Gianfrilli Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Andrea M Isidori Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Cosimo Durante Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Carlotta Pozza Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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on behalf of TALENT Group
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Introduction Thyroid nodular disease is less frequent in children than in adults. The prevalence of palpable nodules in the adult population is 4–7%, and when the detection is made by ultrasound (US) or autoptic exam, the percentage arise to

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Hai-Yan Jia Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

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Juan Chen Department of Ultrasound, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China

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Zi-Xin Zhai Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

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Wen-Wen Fan Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

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Si-Jie Yuan Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

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Qiong Liu Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

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Xiao-Hui Yan Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

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Qian-Qian Shen Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

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Li-Ping Liu Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

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characteristics and the important diagnostic role of FNAB/CNB in the previous literature. Novel insights New information 1: Thyroid metastasis from ccRCC mostly appeared as a single solid or partially cystic nodule with clear borders, usually

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