Wilmar M. Wiersinga
Wilmar M. Wiersinga
Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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mortality [ 23 ]. It suggests tolerance for lower thyroid hormone levels in older people, in agreement with the guidelines to be rather conservative in prescribing levothyroxine to elderly subjects with SHypo [ 2 ]. The data support shifting the upper normal
Roberto Negro
Roberto Negro
Division of Endocrinology, “V. Fazzi” Hospital, Lecce
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Roberto Attanasio
Roberto Attanasio
Endocrinology Service, Galeazzi Institute IRCCS, Milan
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Franco Grimaldi
Franco Grimaldi
Endocrinology and Metabolic Disease Unit, Azienda Ospedaliero-Universitaria “S. Maria della Misericordia,” Udine
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Andrea Frasoldati
Andrea Frasoldati
Division of Endocrinology, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia
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Rinaldo Guglielmi
Rinaldo Guglielmi
Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy
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Enrico Papini
Enrico Papini
Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy
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selected individuals, with higher frequencies in women and the elderly [ 1 , 2 ]. Most nodules are asymptomatic, are not associated with thyroid dysfunction, and do not cause compressive symptoms or cosmetic concerns. However, widespread use of imaging
Roberto Negro
Roberto Negro
Division of Endocrinology, ‘V. Fazzi' Hospital, Lecce
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Giacomo Greco
Giacomo Greco
Faculty of Medicine, San Raffaele Hospital, Milan, Italy
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A, Witteman JC: Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 2000;132:270-278. 10.7326/0003-4819-132-4-200002150-00004 10681281 3
Rodrigo Moreno-Reyes
Rodrigo Moreno-Reyes
Department of Nuclear Medicine, Hospital Erasme, Université Libre de Bruxelles, Brussels, Belgium
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Ulla Feldt-Rasmussen
Ulla Feldt-Rasmussen
Department of Endocrinology and Metabolism, University Hospital Rigshospitalet, and Faculty of Ηealth and Clinical Sciences, University of Copenhagen, Copenhagen, Denmark
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Agnieszka Piekiełko-Witkowska
Agnieszka Piekiełko-Witkowska
Centre of Postgraduate Medical Education, Centre of Translational Research, Department of Biochemistry and Molecular Biology, Warsaw, Poland: Basic Lead of the European Society of Endocrinology Focus Area on Thyroid
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Adriana Gaspar da Rocha
Adriana Gaspar da Rocha
Public Health Unit, ULS Baixo Mondego, Figueira da Foz, Portugal Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
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Corin Badiu
Corin Badiu
National Institute of Endocrinology "C. Davila" University of Medicine and Pharmacy, Bucharest, Romania
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Josef Köhrle
Josef Köhrle
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Experimentelle Endokrinologie, Berlin, Germany: Co-Lead of the European Society of Endocrinology Focus Area on Environmental Endocrinology
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Leonidas Duntas
Leonidas Duntas
Evgenideion Hospital, Unit of Endocrinology, Metabolism and Diabetes, National Kapodistrian University of Athens, Athens, Greece
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Infertility, impaired mental function Decreased work capability Spontaneous hyperthyroidism in the elderly Iodine-induced hyperthyroidism Higher ratio of the more aggressive follicular to papillary thyroid cancers
Francesca Orsolini
Francesca Orsolini
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Alessandro Prete
Alessandro Prete
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Pierpaolo Falcetta
Pierpaolo Falcetta
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Domenico Canale
Domenico Canale
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Fulvio Basolo
Fulvio Basolo
Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy
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Greta Alì
Greta Alì
Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy
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Francesca Manassero
Francesca Manassero
Division of Urology, Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy
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Paolo Vitti
Paolo Vitti
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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metastases from the prostate are seen in the elderly, about one-third of patients with testicular metastasis from other cancer than prostatic one can present at a relatively younger age, as in the present case. Indeed, secondaries from the stomach and small
Georgios Kostopoulos
Georgios Kostopoulos
Department of Endocrinology and Metabolism, Ippokratio General Hospital of Thessaloniki, Greece
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Grigoris Effraimidis
Grigoris Effraimidis
Department of Endocrinology and Metabolic Diseases, Larissa University Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
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4189 5.7% Auer et al. ( 17 ) 2001 Austria RS 23,638 – Euthyroid 22,300 2.3% oHT 725 Elderly 13.8% RR 5.8 (2.7–8.5) Osman et al. ( 38 ) 2007 UK P
Line Tang Møllehave
Line Tang Møllehave
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Nils Knudsen
Nils Knudsen
Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Denmark
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Allan Linneberg
Allan Linneberg
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Inge Bülow Pedersen
Inge Bülow Pedersen
Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark
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Gitte Ravn-Haren
Gitte Ravn-Haren
Research Group for Risk Benefit, National Food Institute, Technical University of Denmark, Lyngby, Denmark
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Anja Lykke Madsen
Anja Lykke Madsen
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Allan Carlé
Allan Carlé
Department of Endocrinology and Medicine, Aalborg University Hospital, Aalborg, Denmark
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Charlotte Cerqueira
Charlotte Cerqueira
The Danish Clinical Quality Program – National Clinical Registries (RKKP), Denmark
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Anne Krejbjerg
Anne Krejbjerg
Department of Oncology, Aalborg University Hospital, Aalborg, Denmark
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Lone Banke Rasmussen
Lone Banke Rasmussen
Independent researcher, Klemensker, Denmark
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Lars Ovesen
Lars Ovesen
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Hans Perrild
Hans Perrild
Department of Endocrinology, Bispebjerg University Hospital, University of Copenhagen, Denmark
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Lena Bjergved Sigurd
Lena Bjergved Sigurd
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark
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Department of Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark
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Betina Heinsbæk Thuesen
Betina Heinsbæk Thuesen
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Pernille Vejbjerg
Pernille Vejbjerg
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Torben Jørgensen
Torben Jørgensen
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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observations of ID were accompanied by observations of a higher prevalence of enlarged thyroid or goiter ( 7 ), thyroid nodules, and subsequent hyperthyroidism ( 10 , 11 ), especially in elderly women and in the most iodine-deficient areas ( 11 ). Further
Henry Völzke
Henry Völzke
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Iris Erlund
Iris Erlund
Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland
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Alicja Hubalewska-Dydejczyk
Alicja Hubalewska-Dydejczyk
Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
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Till Ittermann
Till Ittermann
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Robin P. Peeters
Robin P. Peeters
Department of Internal Medicine, Rotterdam Thyroid Centre, Erasmus Medical Centre, Rotterdam, The Netherlands
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Margaret Rayman
Margaret Rayman
University of Surrey, Surrey, United Kingdom
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Monika Buchberger
Monika Buchberger
Department of Public Health and Health Technology Assessment, UMIT, University for Health Science, Medical Informatics and Technology, Hall, Austria
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Uwe Siebert
Uwe Siebert
Department of Public Health and Health Technology Assessment, UMIT, University for Health Science, Medical Informatics and Technology, Hall, Austria
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Betina H. Thuesen
Betina H. Thuesen
Research Centre for Prevention and Health, Glostrup, Denmark
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Michael B. Zimmermann
Michael B. Zimmermann
Swiss Federal Institute of Technology, Zürich Department of Health Sciences and Technology, Zürich, Switzerland
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Stefan Grünert
Stefan Grünert
Biolution GmbH, Vienna, Austria
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John H. Lazarus
John H. Lazarus
Institute of Molecular Medicine, Cardiff University, Cardiff, United Kingdom
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, Pedersen KM, Hreidarsson A, Sigfusson N, Iversen E, Knudsen PR: Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. J Clin Endocrinol Metab 1998
Chi-Yu Kuo
Chi-Yu Kuo
Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan
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Po-Sheng Yang
Po-Sheng Yang
Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan
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Ming-Nan Chien
Ming-Nan Chien
Division of Endocrinology and Metabolism, Department of Internal Medicine, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan
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Shih-Ping Cheng
Shih-Ping Cheng
Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan
Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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profiling in elderly cancer patients reveals aging-altered immune cells and immune checkpoints . Int J Cancer . 2019 Apr ; 144 ( 7 ): 1657 – 63 . 10.1002/ijc.31875 30230534 0020-7136 32 Schmid D , Ricci C , Behrens G , Leitzmann MF
Ladan Mehran
Ladan Mehran
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Atieh Amouzegar
Atieh Amouzegar
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Hengameh Abdi
Hengameh Abdi
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Negar Delbari
Negar Delbari
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Elham Madreseh
Elham Madreseh
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
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Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
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Maryam Tohidi
Maryam Tohidi
Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Mohammad Ali Mansournia
Mohammad Ali Mansournia
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
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Fereidoun Azizi
Fereidoun Azizi
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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findings to other populations. Coexistence of MetS and TD may aggravate their common metabolic features which might strongly impact the health of populations especially in hypothyroid elderly subjects regarding cardiovascular and metabolic risk factors
