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Germán A. Jimenez Londoño Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Ana Maria Garcia Vicente Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Julia Sastre Marcos Department of Endocrinology, Complejo Hospitalario de Toledo, Toledo, Spain

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Francisco Jose Pena Pardo Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Mariano Amo-Salas Department of Mathematics, University of Castilla-La Mancha, Ciudad Real, Spain

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Manuel Moreno Caballero Department of Nuclear Medicine, Hospital Universitario Infanta Cristina Badajoz, Badajoz, Spain

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Maria Prado Talavera Rubio  Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Beatriz Gonzalez Garcia Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Niletys Dafne Disotuar Ruiz Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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Angel Maria Soriano Castrejón Nuclear Medicine Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain

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the real endpoints. Thus, different systems have been used to predict the prognosis of patients with thyroid cancer. Recently, the 2015 American Thyroid Associations (ATA) guidelines have added a dynamic risk assessment system, which classifies the

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Marie Alix Balay Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France

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Patrick Aidan American Hospital of Paris, Neuilly sur Seine, France

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Marie Helene Schlageter Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France

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Odette Georges American Hospital of Paris, Neuilly sur Seine, France

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Taly Meas Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France

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Maroun Bechara American Hospital of Paris, Neuilly sur Seine, France

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Marie Elisabeth Toubert Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France

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Isabelle Faugeron Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France

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Herve Monpeyssen American Hospital of Paris, Neuilly sur Seine, France

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Cécile N. Chougnet Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France

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Thyroid Association (ATA) guidelines [ 2 ] for the management of thyroid cancer changed in 2015: they now advocate a more appropriate and risk-adapted approach to both the diagnosis and treatment of thyroid cancer. Regarding RAI therapy, the lowest

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Shirley Langham Departments of Endocrinology, Great Ormond Street Hospital, Hospital for Children

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Peter Hindmarsh Developmental Endocrinology Research Group, Institute of Child Health, University College London, London, UK

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Steven Krywawych Departments of Chemical Pathology, Great Ormond Street Hospital, Hospital for Children

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Catherine Peters Departments of Endocrinology, Great Ormond Street Hospital, Hospital for Children
Developmental Endocrinology Research Group, Institute of Child Health, University College London, London, UK

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To allow comparison with the UKNSPC guidelines, TSH values >20 mU/l are presented as positive and 10-19.9 mU/l as borderline on the first screen. These cut-off points were then compared to the additional information generated by operating the GOSH

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Enrico Papini Department of Endocrinology and Metabolism, Regina Apostolorum Hospital, Rome, Italy

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Hervé Monpeyssen Thyroid Unit, American Hospital, Paris, France

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Andrea Frasoldati Department of Endocrinology and Metabolism, Arcispedale Santa Maria Nuova IRCCS-ASL, Reggio Emilia, Italy

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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the highest possible level of evidence derived from studies carried out in a European setting. These guidelines address the optimization of the use of innovative therapeutic tools in clinical management of benign thyroid nodules. They address the

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Roberto Attanasio Endocrine Unit, IRCCS Istituto Galeazzi, Milan, Italy

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Enrico Papini Department of Endocrinology and Metabolism, Ospedale Regina Apostolorum, Rome, Italy

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Kristian H. Winther Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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use in mild GO is recommended in current ETA guidelines [ 29 , 30 ]. An Italian survey, published in 2016, investigated the clinical use of Se supplementation in the index case of a 42-year-old female patient with GD. In the absence of GO, only 20% of

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Bjarke Borregaard Medici Department of Endocrinology, Herlev University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jeppe Lerche la Cour Department of Endocrinology, Herlev University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Luba Freja Michaelsson Department of Endocrinology, Herlev University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jens Oscar Faber Department of Endocrinology, Herlev University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Birte Nygaard Department of Endocrinology, Herlev University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Background Hypothyroidism is a common disease that affects primarily women with a range of symptoms. Levothyroxine (L-T 4 ) is the mainstay replacement therapy of choice according to guidelines, but some patients report persistent hypothyroid

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Irene Campi Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Marco Dell’Acqua Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Elisa Stellaria Grassi Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Maria Cristina Vigone Department of Paediatrics, IRCCS San Raffaele Hospital, Milan, Italy

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Luca Persani Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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robust and accurate biomarker to diagnose primary thyroid dysfunctions, and accordingly, the guidelines endorsed by several scientific societies recommend a reflex TSH testing strategy as a first-line screen for thyroid dysfunction in the general

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Jingyue Chen Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China

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Chenyan Li Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China

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Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China

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Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China

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Jun Jin Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yining Wei Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Jing Sun Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yushu Li Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China

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Huifang Zhou Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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guidelines for GO ( 9 ). The guidelines were updated in 2021 ( 10 ). In 2022, the American Thyroid Association (ATA) and the ETA jointly published a consensus statement for TED ( 11 ). These guidelines and consensus statements provide reliable and

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María de los Ángeles Garayalde Gamboa Service of Endocrinology, Metabolism, Nutrition, and Diabetes, Buenos Aires British Hospital, Buenos Aires, Argentina

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Melina Saban Service of Endocrinology, Metabolism, Nutrition, and Diabetes, Buenos Aires British Hospital, Buenos Aires, Argentina

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Marina Ines Curriá Service of Endocrinology, Metabolism, Nutrition, and Diabetes, Buenos Aires British Hospital, Buenos Aires, Argentina

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be used as an alternative therapy. However, there are no guidelines or consensus about the correct use of parenteral LT4, and there are very few studies assessing the effectiveness and safety of parenteral LT4 as an alternative to oral LT4. On the

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Sophie Demartin Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Stefan Matei Constantinescu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Kris G Poppe Endocrine Unit, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Dominique Maiter Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Raluca Maria Furnica Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Orsalia Alexopoulou Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Chantal Daumerie Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Frederic Debiève Department of Obstetrics, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Maria-Cristina Burlacu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

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Introduction Hypothyroidism diagnosed during pregnancy, whether subclinial or overt, is associated with adverse pregnancy and neonatal outcomes ( 1 ). Existing guidelines unanimously recommend the treatment of overt hypothyroidism (OH) in this

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