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Jesper Karmisholt Department of Medical Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Clinical Institute, Aalborg University, Aalborg, Denmark

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Stig Andersen Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
Clinical Institute, Aalborg University, Aalborg, Denmark

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measure. Data are now available and the change needed for true change is provided. Patients with SCH and unremitting TSH above 10 mU/L have increased risk of a cardiovascular event and mortality in observational studies [ 21 ]. Thus, patients with this

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Estefanía Rinaldini Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina

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Fiorella Campo Verde Arboccó Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina

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Marcelo Ezquer Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile

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Carlos Gamarra-Luques Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina
Facultad de Ciencias Médicas, Instituto de Fisiología, Universidad Nacional de Cuyo, Mendoza, Argentina

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María Belén Hapon Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina
Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Mendoza, Argentina

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Introduction Thyroid diseases cause menstrual disturbances, reduced fertility, recurrent pregnancy loss, perinatal mortality, and lactational deficit [ 1 , 2 ]. We have demonstrated that hypothyroidism delays the onset of parturition, reduces

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Yuwei Liu Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Shengcai Wang Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Yanzhen Li Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Xuexi Zhang Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Zhiyong Liu Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Qiaoyin Liu Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Nian Sun Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Jie Zhang Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Wentong Ge Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Yongli Guo Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Yuanhu Liu Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Xiaolian Fang Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Tingting Ji Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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Jun Tai Children’s Hospital Capital Institute of Pediatrics, Department of Otolaryngology, Head and Neck Surgery, Beijing, China

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Xin Ni Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China
Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health (NCCH), Beijing, China

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the mortality is about 0.02 deaths per 1,00,000 persons [ 1 ]. An analysis based on the surveillance, epidemiology, and end results database and revealed the annual incidence of DTC was 0.54 cases per 1,00,000 persons in children [ 2 ], and it was

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Beng Khiong Yap The Christie NHS Foundation Trust

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Jarrod Homer Central Manchester NHS Foundation Trust

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Neil Parrott Central Manchester NHS Foundation Trust

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Sean Loughran Central Manchester NHS Foundation Trust

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Brian Murby The Christie NHS Foundation Trust

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Ric Swindell The Christie NHS Foundation Trust

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Ashu Gandhi University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK

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recommend total or near-total thyroidectomy for differentiated thyroid carcinoma (DTC) of >1 cm [ 5 , 6 ]. Although the surgical mortality associated with thyroidectomy is low [ 2 ], the potential long-term complications of recurrent laryngeal nerve palsy

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Fabián Pitoia Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires

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Fernando Jerkovich Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires

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Anabella Smulever Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires

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Gabriela Brenta Division of Endocrinology, Dr. César Milstein Hospital, Buenos Aires, Argentina

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Fernanda Bueno Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires

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Graciela Cross Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires

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Introduction Various staging systems have historically been used to assess the risk of mortality in patients with differentiated thyroid cancer (DTC) [ 1 , 2 , 3 , 4 , 5 ]. All of them are strongly dependent on patient age since age at

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Ho-Ryun Won Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University Sejong Hospital, Sejong, Republic of Korea

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Min Gyu Kim Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea

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Min Soo Kim Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea

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Jae Won Chang Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea

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Bon Seok Koo Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea

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characterized by a rapid increase in incidence and a reduced mortality rate, which is thought to have resulted from the increase in diagnostic sensitivity due to advances in diagnostic technology, including ultrasonography ( 4 , 5 ). This trend has led to an

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Bruno Bouça Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Ana Cláudia Martins Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Paula Bogalho Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Lídia Sousa Cardiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Tiago Bilhim Interventional Radiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Filipe Veloso Gomes Interventional Radiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Élia Coimbra Interventional Radiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Ana Agapito Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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José Silva-Nunes Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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, thus, a major cause of morbidity and mortality. Amiodarone is widely considered to be the most effective antiarrhythmic drug, even for the CHD population. Treatment with this class III anti-arrhythmic drug is commonly used in these patients as it is

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Oleksiy Tsybrovskyy Diagnostic and Research Institute of Pathology, Medical University of Graz, Austria

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Manuel Sobrinho-Simões Department of Molecular Pathology and Immunology of the University of Porto, Portugal

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Giovanni Tallini Head of the Endocrine Pathology program, University of Bologna Medical Center, Bologna, Italy

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& Franklyn JA . Differences in the recurrence and mortality outcomes rates of incidental and nonincidental papillary thyroid microcarcinoma: a systematic review and meta-analysis of 21 329 person-years of follow-up . Journal of Clinical Endocrinology and

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Saleha Babli Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada
Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia

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Richard J.  Payne Department of Otolaryngology, Royal Victoria Hospital, McGill University, Montreal, Québec, Canada

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Elliot Mitmaker Department of Surgery, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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Juan Rivera Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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study by Kashima et al. [ 5 ] reported a 0.7% cancer-specific mortality rate and a 95% relapse-free 10-year survival rate in patients with CLT compared to a 5% mortality and 85% relapse-free 10-year survival rate for those without CLT. Furthermore, CLT

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Lars Folkestad Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Frans Brandt Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark

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Thomas Brix Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Marianne Vogsen Department of Oncology, Odense University Hospital, Odense, Denmark

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Lars Bastholt Department of Oncology, Odense University Hospital, Odense, Denmark

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Peter Grupe Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark

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Jeanette  Krogh Petersen Department of Clinical Pathology, Odense University Hospital, Odense, Denmark

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark

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increased risk of thyroid cancer (TC) [ 8 , 9 ], although surveillance bias may, at least partly, explain the latter. Whether GD, which is associated with excess mortality [ 10 ], affects the prognosis of differentiated TC is still a matter of controversy

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