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Noha Mukhtar Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Hadeel Aljamei Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Abeer Aljomaiah Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Yosra Moria Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Ali S. Alzahrani Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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risk of recurrence and mortality [ 8 ]. Tumors that are low risk are usually treated more conservatively with lobectomy and do not routinely receive radioactive iodine (I-131) while high-risk tumors are treated more proactively with total or near

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Carla Colombo Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Daniele Ceruti Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Simone De Leo Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy

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Grzegorz Bilo Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy

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Matteo Trevisan Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Noemi Giancola Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Claudia Moneta Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Gianfranco Parati Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy

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Luca Persani Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Laura Fugazzola Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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-up of advanced radioiodine-refractory thyroid cancer . European Thyroid Journal 2019 8 227 – 245 . ( https://doi.org/10.1159/000502229 ) 2 Dadu R & Cabanillas ME . Optimizing therapy for radioactive iodine-refractory differentiated thyroid

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Andries H Groen Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Deborah van Dijk Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Wim Sluiter Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Thera P Links Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Hendrik P Bijl Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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John T M Plukker Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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by radioactive iodine ( 131 I) and thyroid-stimulating hormone suppression therapy ( 2 , 3 , 4 ). However, 15–33% of DTC patients have a primary iodine refractory-differentiated thyroid cancer (IR-DTC) or develop IR-DTC after several sessions of

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Abdul Rehman Syed University of Calgary, Calgary, Alberta, Canada

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Aakash Gorana Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada

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Erik Nohr Alberta Precision Laboratories, Molecular Pathology Program, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Xiaoli-Kat Yuan Precision Oncology Hub Laboratory, Tom Baker Cancer Centre, Calgary, Alberta, Canada

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Parthiv Amin MASc Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary Alberta, Canada

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Sana Ghaznavi Arnie Charbonneau Cancer Institute, Department of Medicine, Section of Endocrinology, University of Calgary, Calgary, Alberta, Canada

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Debbie Lamb Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada

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John McIntyre Precision Oncology Hub Laboratory, Tom Baker Cancer Centre, Calgary, Alberta, Canada

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Markus Eszlinger Department of Oncology, Cumming School of Medicine, and Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada

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Ralf Paschke Departments of Medicine, Section of Endocrinology, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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– 1035 . ( https://doi.org/10.1158/1078-0432.CCR-14-2915 ) 8 Groussin L Clerc J & Huillard O . Larotrectinib-enhanced radioactive iodine uptake in advanced thyroid cancer . New England Journal of Medicine 2020 383 1686 – 1687 . ( https

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E.N. Klein Hesselink Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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T.P. Links Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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, Goellner JR, Morris JC, Heufelder AE: Analysis of human sodium iodide symporter immunoreactivity in human exocrine glands. J Clin Endocrinol Metab 1999;84:4178-4184. 10.1210/jcem.84.11.6117 10566669 8 Mandel SJ, Mandel L: Radioactive iodine and the

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Nicholas S. Andresen Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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John M. Buatti Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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Hamed H. Tewfik Iowa City Cancer Treatment Center, Iowa City, Iowa, USA

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Nitin A. Pagedar Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA

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Carryn M. Anderson Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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John M. Watkins Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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systematic review and meta-analysis of radioactive iodine remnant ablation for well-differentiated thyroid cancer: J Clin Endocrinol Metab 2002;89: 3668–3676. 10.1210/jc.2003-031167 15292285 3 Hay ID, Thompson GB, Grant CS, Bergstralh EJ, Dvorak CE

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Rosa M. García-Moreno Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain

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Cristina Escabias Nuclear Medicine Department, Hospital Universitario La Paz, Madrid, Spain

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Cristina Utrilla Radiology Department, Hospital Universitario La Paz, Madrid, Spain

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Elena Ruiz-Bravo Pathology Department, Hospital Universitario La Paz, Madrid, Spain

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Margarita Sánchez Ophthalmology Department, Hospital Universitario La Paz, Madrid, Spain

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Beatriz Lecumberri Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain

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radioactive iodine [ 2 ]. While, globally, the most common metastatic sites are cervical lymph nodes, distant metastases typically involve lungs, bones, and, less frequently, the brain [ 3 ]. Only in rare cases, patients may present metastases in unusual

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Andrew J Bauer Division of Endocrinology and Diabetes, The Children’s Hospital of Philadelphia, Department of Pediatrics, The University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Jonathan D Wasserman Division of Endocrinology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

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Steven G Waguespack Department of Endocrine Neoplasia and Hormonal Disorders and Department of Pediatrics-Patient Care, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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human thyroid-stimulating hormone for radioactive iodine (RAI) imaging and therapy, reducing the minimum time on a low-iodine diet to 4 days prior to 131 I, and modifying the recommendation for lifelong surveillance from the 2015 ATA Pediatric

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Chantal Daumerie Service Endocrinologie, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium

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Jacques Orgiazzi Hospices Civils de Lyon, Université Claude-Bernard Lyon 1, Lyon, France

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, three options may be considered: a second course of antithyroid drug, continuation of the antithyroid drug at low dose if appropriate, or radical treatment – either total thyroidectomy or radioactive iodine. Another important observation is that GD, and

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Kathrin A. Schmohl Department of Internal Medicine II, Germany

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Andrea M. Müller Department of Internal Medicine II, Germany

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Nathalie Schwenk Department of Internal Medicine II, Germany

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Kerstin Knoop Department of Internal Medicine II, Germany

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Eddy Rijntjes Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Josef Köhrle Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Heike Heuer Leibniz Institute for Environmental Medicine, Düsseldorf, Germany

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Peter Bartenstein Department of Nuclear Medicine, Germany

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Burkhard Göke Department of Internal Medicine II, Germany

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Peter J. Nelson Medical Policlinic IV, University Hospital of Munich, Munich, Germany

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Christine Spitzweg Department of Internal Medicine II, Germany

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tissues in mice. Proc Soc Exp Biol Med 1947;66:212-213. 10.3181/00379727-66-16040P 20270727 4 Gorbman A: Functional and structural changes consequent to high dosages of radioactive iodine. J Clin Endocrinol Metab 1950;10:1177-1191. 10.1210/jcem-10

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