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Introduction In the last few years, the use of immune checkpoint inhibitors (ICIs) in the treatment of several types of solid cancers greatly increased. ICIs are monoclonal antibodies blocking regulatory molecules expressed on T cells, such as
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Introduction Hypothyroidism is very common and affects up to 10% of the female population [ 1 ]. Many patients do not feel well on standard levo-thyroxine (L-T4) treatment [ 2 - 5 ], and many patients may benefit from experimental treatment
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Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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soon as possible to avoid delays in treatment. Therefore, it is crucial to predict the response of TED patients to GC therapy before initiating treatment. Through this study, we aimed to obtain a simple and accurate method to help predict the response
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the digit and choroid with pulmonary metastasis. k USG B scan with tumor regression after 131 I treatment. I Complete regression of the digital metastasis after 131 I treatment. Case Details A 54-year-old female presented with a
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Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
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may be considered in some cases [ 3 ], but a recent study showed that this treatment had no effect on pregnancy or neonatal outcomes in women with a history of reproductive failure [ 11 ]. Additionally, subclinical hyperthyroidism has not been
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: ØØØO. Agreement: 9/9 (100%); round: 1 ) Consider TA for the treatment of solid benign thyroid nodules that cause local symptoms as an alternative to surgery and for cystic lesions that relapse after EA l ( Strength of recommendation: 1; quality
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An 87-year-old woman was referred to our department for a 15 cm right-sided cervical tumor with bleeding skin ulceration, signs of local infection ( Fig. 1 , panel A and B ), and limited cervical mobility. Surprisingly, there were no other
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Departments of Scuola Superiore Sant'Anna, Pisa, Italy
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Directive (2010/63/UE) and Italian law (D.L. 26/2014). The study was approved by the Local Ethical Approval Panel. Twenty Wistar outbred albino rats (2-3 months of age, both genders) were kept in our local animal husbandry facility and housed 1-2 per cage in
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. Anti-thyroid drugs (ATD) have become the first-choice treatment for newly diagnosed Graves’ hyperthyroidism; however, this approach is hampered by a 50–55% relapse rate after an appropriate course of ATD ( 6 ). The presence of TED (thyroid eye disease
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mutation occurs in codon M918, reported in up to 90% of RET-positive MTC cases ( 2 ). Selpercatinib and pralsetinib, tyrosine-kinase inhibitors with high specificity for RET protein, recently obtained FDA approval for the treatment of lung and thyroid