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Lise Husted Department of Clinical Biochemistry, Viborg Regional Hospital, Viborg, Denmark

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Sidsel Rødgaard-Hansen Department of Clinical Biochemistry, Viborg Regional Hospital, Viborg, Denmark

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Maja Hjelm Lundgaard Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Nanna Maria Uldall Torp Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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a coefficient of variation (CV) less than 10%. The reference interval for nonpregnant adults recommended by the manufacturer was 0.64–1.23 mg/L. The measurement range for creatinine was 9.0–13,260 µmol/L, and the reference interval recommended by the

Article Type:
Research Article
Collections:
Thyroid and reproduction
DOI:
https://doi.org/10.1530/ETJ-23-0157
Volume/Issue:
Volume 12: Issue 6
Open access
Zohar Steinberg Ben-Zeev Pediatric Department A, Ha’Emek Medical Center, Afula, Israel

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Marina Peniakov Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel

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Clari Felszer Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel

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Scott A Weiner Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel

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Avishay Lahad Pediatric Department A, Ha’Emek Medical Center, Afula, Israel

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Shlomo Almashanu The National Newborn Screening Program, Ministry of Health, Tel Hashomer, Ramat Gan, Israel

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Yardena Tenenbaum Rakover Consulting Medicine in Pediatric Endocrinology, Clalit Health Services, Afula, Israel
The Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel

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within the normal reference range ( Table 4 ). Newborns with elevated TSH (above 10 mIU/L) were followed by repeated TFT until TSH levels normalized. Table 4 Elevated TSH values in newborns. TSH > 10 mIU/L ( n   = 87) TSH > 20 mIU

Article Type:
Research Article
Collections:
Thyroid and reproduction
DOI:
https://doi.org/10.1530/ETJ-22-0055
Volume/Issue:
Volume 11: Issue 4
Open access
Carla Colombo Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Daniele Ceruti Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Massimiliano Succi Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Simone De Leo Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Matteo Trevisan Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Claudia Moneta Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Laura Fugazzola Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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patients treated with VAN and white dots represent patients treated with SELP. Nine male patients (100%) and 11/17 (65%) female patients showed Δ4 androstenedione values below the median of the reference range (of which 10 patients below the 5th percentile

Article Type:
Research Article
Collections:
Thyroid cancer - basic and translational
DOI:
https://doi.org/10.1530/ETJ-23-0246
Volume/Issue:
Volume 13: Issue 3
Open access
Tetsuya Mizokami Tajiri Thyroid Clinic, Kumamoto

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Shuji Fukata Tajiri Thyroid Clinic, Kumamoto
Department of Medicine, Kuma Hospital, Kobe

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Akira Hishinuma Department of Infection Control and Clinical Laboratory Medicine, Dokkyo Medical University, Tochigi, Japan

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Takahiko Kogai Department of Infection Control and Clinical Laboratory Medicine, Dokkyo Medical University, Tochigi, Japan

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Katsuhiko Hamada Tajiri Thyroid Clinic, Kumamoto

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Tetsushi Maruta Tajiri Thyroid Clinic, Kumamoto

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Kiichiro Higashi Tajiri Thyroid Clinic, Kumamoto

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Junichi Tajiri Tajiri Thyroid Clinic, Kumamoto

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]. The coefficient of variation was less than 15%, the detection limit 25 μg/l, and the range of measurement 25-500 μg/l [ 2 ]. The accuracy of the kit was 80-120% of the value determined by inductively coupled plasma mass spectrometry [ 2 ]. Samples

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000446496
Volume/Issue:
Volume 5: Issue 2
Free access
Yun Jeong Lee Department of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of Korea
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea

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Young Hun Choi Department of Radiology, Seoul National University Hospital, Seoul, Korea

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Youn-Hee Lim Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea
Environmental Health Center, Seoul National University College of Medicine, Seoul, Republic of Korea

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Bung-Nyun Kim Division of Children and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea

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Johanna Inhyang Kim Department of Psychiatry, Hanyang University Medical Center, Seoul, Republic of Korea

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Yun-Chul Hong Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea
Environmental Health Center, Seoul National University College of Medicine, Seoul, Republic of Korea
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

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Young Joo Park Department of Internal medicine, Seoul National University Hospital, Seoul, Republic of Korea
Department of Internal medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

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Choong Ho Shin Department of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of Korea
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea

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Sun Wook Cho Department of Internal medicine, Seoul National University Hospital, Seoul, Republic of Korea
Department of Internal medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

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Young Ah Lee Department of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of Korea
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea

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thyroid function Free thyroxine (FT4) and thyroid stimulating hormone (TSH) were measured using a chemiluminescent microparticle immune assay on an ARCHITECT i2000 System (Abbott Korea). The reference range was defined as 0.70–1.48 ng/dL (9.01–19.05 pmol

Article Type:
Research Article
Collections:
Environment and thyroid function
DOI:
https://doi.org/10.1530/ETJ-23-0219
Volume/Issue:
Volume 12: Issue 6
Open access
Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Stig Andersen Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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population-based reference ranges. TSH is also the first-line thyroid function test for the diagnosis of thyroid dysfunction in pregnant women, but the physiological alterations in pregnancy necessitate the use of a pregnancy-specific reference range [ 12

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000506228
Volume/Issue:
Volume 9: Issue 5
Free access
Jesper Karmisholt Department of Medical Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Clinical Institute, Aalborg University, Aalborg, Denmark

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Stig Andersen Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
Clinical Institute, Aalborg University, Aalborg, Denmark

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Introduction Subclinical hypothyroidism (SCH) is a frequent condition defined by serum values of thyrotropin (TSH) above and thyroxine (T4) within the population-based reference ranges[ 1 - 3 ]. It may reflect mild thyroid failure with only

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000496827
Volume/Issue:
Volume 8: Issue 3
Free access
David Shaki Pediatric Endocrinology Unit, Saban Pediatric Medical Center for Israel, Beer Sheva, Israel
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Marina Eskin-Schwartz Genetics Institute at Soroka University Medical Center and the Morris Kahn Laboratory of Human Genetics, National Center for Rare Diseases, at the Faculty of Health Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Noam Hadar Genetics Institute at Soroka University Medical Center and the Morris Kahn Laboratory of Human Genetics, National Center for Rare Diseases, at the Faculty of Health Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Emily Bosin Endocrinology Lab, Soroka University Medical Center, Beer Sheva, Israel

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Lior Carmon Pediatric Endocrinology Unit, Saban Pediatric Medical Center for Israel, Beer Sheva, Israel
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Samuel Refetoff Departments of Medicine and Pediatrics and the Committee on Genetics, The University of Chicago, Chicago, Illinois, USA

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Eli Hershkovitz Pediatric Endocrinology Unit, Saban Pediatric Medical Center for Israel, Beer Sheva, Israel
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Ohad S Birk Genetics Institute at Soroka University Medical Center and the Morris Kahn Laboratory of Human Genetics, National Center for Rare Diseases, at the Faculty of Health Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel

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Alon Haim Pediatric Endocrinology Unit, Saban Pediatric Medical Center for Israel, Beer Sheva, Israel
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

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heterozygotes have been reported to have reduced TSH levels within the reference range. The R75G variant has been reported to be prevalent in individuals of South Asian ethnicity ( 2 ) including Pakistan and India ( 3 ). Clinically, individuals homozygous for

Article Type:
Research Article
Collections:
Hypothalamus-pituitary-thyroid axis
DOI:
https://doi.org/10.1530/ETJ-21-0072
Volume/Issue:
Volume 11: Issue 1
Open access
Stasa Ivkovic Clinical Center of Serbia, Clinic of Otorhinolaryngology and Maxillofacial Surgery, Belgrade, Serbia

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Dear Sir, Five months after radioactive iodine treatment for Graves’ hyperthyroidism, I developed severe hypothyroidism. Three months after treatment, TSH, FT4 and FT3 values were within reference range (0.44 mlU/l, 15.9 and 4.5 pmol

Article Type:
Letter
DOI:
https://doi.org/10.1159/000337977
Volume/Issue:
Volume 1: Issue 2
Free access
Giovanni de Gennaro Department of Clinical and Experimental Medicine, Endocrinology Unit I, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Paolo Vitti Department of Clinical and Experimental Medicine, Endocrinology Unit I, University of Pisa and University Hospital of Pisa, Pisa, Italy

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Michele Marinò Department of Clinical and Experimental Medicine, Endocrinology Unit I, University of Pisa and University Hospital of Pisa, Pisa, Italy

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, and an enlarged thyroid gland of increased consistency and irregular surface. Laboratory data revealed a subclinical hypothyroidism, with a serum TSH concentration of 5.88 μIU/mL (normal range 0.4–4 μIU/mL), an FT3 of 4.08 pg/mL (normal range 2

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000493730
Volume/Issue:
Volume 8: Issue 1
Free access