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Barbara A. Demeneix CNRS/UMR7221, Muséum National d’Histoire Naturelle/Université Paris-Sorbonne, Paris, France

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, either resemble TH or have the capacity to interfere with TH production or action at different physiological levels [ 11 , 12 ]. Given both the importance of maternal iodine and TH levels for early brain development and the documented expansion and

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Shakeel Kautbally Divisions of Endocrinology and Nutrition, Université Catholique de Louvain, Brussels, Belgium

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Orsalia Alexopoulou Divisions of Endocrinology and Nutrition, Université Catholique de Louvain, Brussels, Belgium

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Chantal Daumerie Divisions of Endocrinology and Nutrition, Université Catholique de Louvain, Brussels, Belgium

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François Jamar Divisions of Nuclear Medicine, Université Catholique de Louvain, Brussels, Belgium

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Michel Mourad Divisions of Endocrine Surgery, St. Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium

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Dominique Maiter Divisions of Endocrinology and Nutrition, Université Catholique de Louvain, Brussels, Belgium

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increase of TSI levels over the first 6 months, followed by a slow decrease with a long median time interval to normalization of 18 months. It is known that radioactive iodine administration can induce a temporary surge in all types of thyroid

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Marise Codeco de Andrade Barreto Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Natalia Treistman Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Lara Bessa Campelo Pinheiro Cavalcante Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Daniel Bulzico Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil

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Fernanda Accioly de Andrade Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil

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Rossana Corbo Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil

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Paulo Alonso Garcia Alves Junior Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Fernanda Vaisman Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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with higher RAI have a significant decrease in AMH concentration. The same has been shown by Evranos et al. , who also demonstrated that AMH level decreases shortly after RAI treatment and plateaus at a level lower than the one measured before RAI ( 17

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Georgiana Sitoris Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Flora Veltri Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Pierre Kleynen Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Malika Ichiche Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Serge Rozenberg Department of Gynecology and Obstetrics, Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Kris G Poppe Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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), nutritional factors (iodine and iron), high estradiol levels (ovarian stimulation), high hCG levels (twin pregnancies, during gestational weeks 9–13) and, finally, the variability in the TSH assays ( 1 , 2 , 3 , 4 , 5 , 6 ). In a number of studies, the

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Emna Jelloul Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Georgiana Sitoris Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Flora Veltri Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Pierre Kleynen Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Serge Rozenberg Departement of Gynecology and Obstetrics, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Kris G Poppe Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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including a larger number of women (by the use of individual-participant data meta-analysis), the inclusion of women with different backgrounds (and thus different iodine status and BMI levels), and adjustments made for other variables (hCG and iron reserve

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Eijun Nishihara Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yoshitaka Hobo ASKA Pharmamedical Co., Ltd. Fujisawa, Japan

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Akira Miyauchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yasuhiro Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Miyoko Higuchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuyoshi Hirokawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuru Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Shuji Fukata Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsushige Nishikawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Takashi Akamizu Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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-negative with low to moderate levels of Tg (<426 ng/mL). Group B was comprised of 19 sera that were TgAb-positive and a varying range of Tg from 19 patients with multiple pulmonary metastases from PTCs treated with total thyroidectomy and radioactive iodine

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Tereza Planck Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
Department of Endocrinology, Skåne University Hospital, Malmö, Sweden

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Bushra Shahida Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden

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Johan Malm Department of Translational Medicine, Section for Clinical Chemistry, Lund University, Malmö, Sweden

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Jonas Manjer Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
Department of Surgery, Skåne University Hospital, Malmö, Sweden

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involved in vitamin D metabolism has been associated with several autoimmune disorders including autoimmune thyroid disease [ 2 - 7 ]. Several studies suggest that individuals with Graves disease (GD) have lower vitamin D levels than the general population

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Riccardo Donzelli Departments of Pathology, University of Pisa

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Daria Colligiani Departments of Clinical and Experimental Medicine, University of Pisa

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Claudia Kusmic Departments of CNR Institute of Clinical Physiology, Pisa, Italy

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Martina Sabatini Departments of Pathology, University of Pisa

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Leonardo Lorenzini Departments of Pathology, University of Pisa

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Alice Accorroni Departments of Pathology, University of Pisa
Departments of Scuola Superiore Sant'Anna, Pisa, Italy

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Monica Nannipieri Departments of Clinical and Experimental Medicine, University of Pisa

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Alessandro Saba Departments of Pathology, University of Pisa

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Giorgio Iervasi Departments of CNR Institute of Clinical Physiology, Pisa, Italy

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Riccardo Zucchi Departments of Pathology, University of Pisa

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in figure 2 they are expressed as a ratio to the average baseline concentration. Propylthiouracil administration caused a remarkable reduction of tissue T 3 and T 4 levels in all tissues. The effect was not homogeneous since the ratio to baseline

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Heleen I Jansen Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

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Antonius E van Herwaarden Radboud University Medical Center, Department of Laboratory Medicine, Nijmegen, The Netherlands

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Henk J Huijgen Department of Clinical Chemistry, Red Cross Hospital, Beverwijk, The Netherlands

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Rebecca C Painter Department of Obstetrics and Gynaecology, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Jacquelien J Hillebrand Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands

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Anita Boelen Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Annemieke C Heijboer Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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concentration measured using these IAs was (falsely) higher and reached a comparable level in pregnant women to the concentrations measured by the LC-MS/MS. This example shows the complexity of the process of fT4 standardization for all types of patients and

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Hiroyuki Iwaki Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Kenji Ohba Medical Education Center, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Eisaku Okada Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Takeshi Murakoshi Obstetrics and Gynecology, Maternal and Perinatal Care Center, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Yumiko Kashiwabara Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Chiga Hayashi Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Akio Matsushita Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Shigekazu Sasaki Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Takafumi Suda Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Yutaka Oki Department of Metabolism and Endocrinology, Hamamatsu-Kita Hospital, Hamamatsu, Japan

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Rieko Gemma Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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within 4 weeks of their deliveries and cord FT4 level of their infants at the time of delivery were available. Those who had multiple pregnancies, fetal goiter detected by ultrasonography, iodine or glucocorticoid treatment, and change in ATD after the

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