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Wenxing Guo The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Long Tan The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Shuyao Dong The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Ya Jin The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Mei Zhu The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China

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Hongyan Wei The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China

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Yanting Chen The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Lili Fan The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Cong Du The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Wanqi Zhang The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China
The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China
Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China

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Blanc E , Ponce C , Brodschi D , Nepote A , Barreto A , Schnitman M , . Association between worse metabolic control and increased thyroid volume and nodular disease in elderly adults with metabolic syndrome . Metab Syndr Relat Disord . 2015

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Anna Göbel Departments of Neurology, University of Lübeck, Lübeck, Germany

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Marcus Heldmann Departments of Neurology, University of Lübeck, Lübeck, Germany

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Martin Göttlich Departments of Neurology, University of Lübeck, Lübeck, Germany

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Anna-Luise Dirk Departments of Internal Medicine I, University of Lübeck, Lübeck, Germany

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Georg Brabant Departments of Internal Medicine I, University of Lübeck, Lübeck, Germany

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Thomas F. Münte Departments of Neurology, University of Lübeck, Lübeck, Germany

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correlates of subclinical hypothyroidism in elderly community residents in the southwest of France. Age Ageing 1995;24:235-241. 10.1093/ageing/24.3.235 7645445 12 Burmeister LA, Ganguli M, Dodge HH, Toczek T, DeKosky ST, Nebes RD: Hypothyroidism and

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Jan Calissendorff Department of Clinical Science and Education, Section of Endocrinology, Karolinska Institutet, Södersjukhuset, Sweden

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Emil Mikulski Department of Medicine, Mälarsjukhuset, Eskilstuna, Sweden
Centre for Clinical Research in Sörmland, Uppsala University, Uppsala, Sweden

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Erik H. Larsen National Food Institute, Technical University of Denmark, Søborg, Denmark

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Marika Möller Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
Centre for Clinical Research in Sörmland, Uppsala University, Uppsala, Sweden

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healthy elderly volunteers from the Danish Prevention of Cancer by Intervention by Selenium (PRECISE) pilot study. Br J Nutr 2008;99:1190-1198. 10.1017/S0007114507882948 18062829 22 Xia Y, Hill KE, Byrne DW, Xu J, Burk RF: Effectiveness of selenium

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Roberto Negro Division of Endocrinology, ‘V. Fazzi' Hospital, Lecce

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Roberto Attanasio Endocrinology Service, Galeazzi Institute IRCCS, Milan

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Franco Grimaldi Endocrinology and Metabolic Disease Unit, Azienda Ospedaliero-Universitaria ‘S. Maria della Misericordia', Udine

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Claudio Marcocci Department of Clinical and Experimental Medicine, University of Pisa, Pisa

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Rinaldo Guglielmi Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Enrico Papini Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Rayman MP, Thompson AJ, Bekaert B, Catterick J, Galassini R, Hall E, Warren-Perry M, Beckett GJ: Randomized controlled trial of the effect of selenium supplementation on thyroid function in the elderly in the United Kingdom. Am J Clin Nutr 2008

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Érique José F. Peixoto de Miranda Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Márcio Sommer Bittencourt Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Itamar S. Santos Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Paulo A. Lotufo Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Isabela M. Benseñor Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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;13:362-369. 10.1089/met.2015.0045 26177236 11 Hak AE, Pols HA, Visser TJ, et al: Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 2000

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Fabián Pitoia Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires

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Fernando Jerkovich Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires

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Anabella Smulever Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires

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Gabriela Brenta Division of Endocrinology, Dr. César Milstein Hospital, Buenos Aires, Argentina

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Fernanda Bueno Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires

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Graciela Cross Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires

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Hollenbeak CS, Boltz MM, Schaefer EW, Saunders BD, Goldenberg D: Recurrence of differentiated thyroid cancer in the elderly. Eur J Endocrinol 2013;168:549-556. 10.1530/EJE-12-0848 23337385 28 Orlov S, Orlov D, Shaytzag M, Dowar M, Tabatabaie V, Dwek P

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Sébastien Verdickt Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium

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Falco Van Nes Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium

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Carolien Moyson Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium

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Toon Maes Department of Endocrinology, Imeldaziekenhuis Bonheiden, Bonheiden, Belgium

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Paul Van Crombrugge Department of Endocrinology, OLV Ziekenhuis Aalst-Asse-Ninove, Aalst, Belgium

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Annick Van den Bruel Department of Endocrinology, AZ Sint Jan Brugge, Brugge, Belgium

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Brigitte Decallonne Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium

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L . Determinants and clinical implications of thyroid peroxidase antibodies in middle-aged and elderly individuals: the Rotterdam study . Thyroid 2022 32 78 – 89 . ( https://doi.org/10.1089/thy.2021.0403 ) 18 Vandevijvere S Ruttens A Wilmet

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Alessandro Brancatella Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Laura Pierotti Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Nicola Viola Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Isabella Lupi Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Lucia Montanelli Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Chiara Cremolini Oncology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

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Paolo Piaggi Department of Information Engineering, University of Pisa, Pisa, Italy

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Antonio Chella Pneumology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy

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Andrea Antonuzzo Oncology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

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Daniele Sgrò Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Lucia Antonangeli Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Chiara Sardella Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Sandra Brogioni Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Claudio Marcocci Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Ferruccio Santini Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Francesco Latrofa Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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://pubmed.ncbi.nlm.nih.gov/25905406/ ) 8 Kahaly GJ Nieswandt J Mohr-Kahaly S . Cardiac risks of hyperthyroidism in the elderly . Thyroid 1998 8 1165 – 1169 . ( https://doi.org/10.1089/thy.1998.8.1165 ) 9 Nishihara E Ohye H Amino N Takata K Arishima T Kudo T

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Joke Marlier Department of Endocrinology, Ghent University Hospital, Ghent, Belgium

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Guy T’Sjoen Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium

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Jean Kaufman Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium

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Bruno Lapauw Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium

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, aiming for a universal substitution dose of 1.6 μg/kg body weight per day might hold a risk of overtreatment, especially in elderly patients. But no matter which guidance is followed, one should be aware that due to the important interindividual variation

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Carla Gambale Department of Clinical and Experimental Medicine, Unit of Endocrinology, Pisa University Hospital, Pisa, Italy

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Alessandro Prete Department of Clinical and Experimental Medicine, Unit of Endocrinology, Pisa University Hospital, Pisa, Italy

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Chiara Romei Department of Diagnostic Imaging, Unit of Radiology, Pisa University Hospital, Pisa, Italy

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Alessandro Celi Department of Surgery, Medicine, Molecular Biology and Critical Care, Respiratory Pathophysiology Unit, Pisa University Hospital, Pisa, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, Pisa University Hospital, Pisa, Italy

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Antonio Matrone Department of Clinical and Experimental Medicine, Unit of Endocrinology, Pisa University Hospital, Pisa, Italy

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treatment ( 27 , 28 ). It is also true that OB incidence has been increasing over time, as well as the list of OB-associated drugs ( 26 ). Here, we presented a case of OB in an elderly patient without any recognized risk factor. An association between OB

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