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Thyroid Association guidelines for thyroid cancer management [ 8 , 19 ], LR consisted of T1–2mN0/xM0/x patients, and IR included T1–3N1Mx and T3N0Mx patients. The mean age at diagnosis was 43.3 ± 13.4 years, with a median of 43.5 years. A total of 527
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Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
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Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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) Pediatric Guidelines recommend selective consideration of prophylactic central neck dissection (pCND) for patients with PTC based upon tumor focality, tumor size, and the experience of the surgeon (Recommendation 12B) ( 5 ). This recommendation was based on
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13). The reasons for physicians being reluctant to refer patients to minimally invasive treatments included the absence of dedicated guidelines, uncertainty about clinical outcomes, concern of potential complications and fear of overlooking a thyroid
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(i.e. subacute thyroiditis and type 2 amiodarone-induced thyrotoxicosis) ( 9 , 10 ), recent guidelines and expert opinion recommend no treatment for the destructive forms induced by immunotherapy, since data in this setting are lacking ( 3 , 11
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etiology, seems quite straightforward. According to current guidelines the standard of care is treatment based on hormonal replacement therapy with daily administration of levothyroxine, the pro-hormone produced exclusively by the thyroid gland [ 3 ]. The
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, rim, eggshell), comet-tail artefacts. The ROM was rated according to EU-TIRADS using internally developed standardized report where the nodules were classified into categories 2, 3, 4, or 5 [ 15 ]. EU-TIRADS guidelines recommend FNAB for category 5
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of any randomised trial comparing HT with TT, differential interpretation and implementation of international guidelines by local clinical teams have resulted in variable practices [ 16 , 17 ]. Practice variability and uncertainty could further
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population can be expected ( 3 , 5 , 6 ). If we base the rate of malignancy (ROM) of these nodules on data from current guidelines, between 7 and 15% of the nodules bear a malignancy ( 7 , 8 ). As these data mainly reflect nodules suspected on the basis of
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-dependent influence of ATDs on the difference in FT4 levels between maternal and cord blood in patients with Graves’ disease (GD) [ 2 , 9 ]. In this connection, future research proposed by the ATA guidelines task force includes a trial assessing the optimal target FT
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review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2009 guidelines [ 8 ] and was registered with PROSPERO (ID = CRD42020180889). Literature Search The literature search was performed using