Search for other papers by Peter Laurberg in
Google Scholar
PubMed
Search for other papers by Nils Knudsen in
Google Scholar
PubMed
Search for other papers by Stig Andersen in
Google Scholar
PubMed
Search for other papers by Allan Carlé in
Google Scholar
PubMed
Search for other papers by Inge Bülow Pedersen in
Google Scholar
PubMed
Search for other papers by Jesper Karmisholt in
Google Scholar
PubMed
was modified to change serum TSH by a factor of 10, corresponding to the difference from the lower to the upper limit of the laboratory reference range for serum TSH (0.4–4.0 mU/l). Based on data from many studies, Eisenberg and Distefano [ 11
Institute of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
Search for other papers by Mats Holmberg in
Google Scholar
PubMed
Search for other papers by Helge Malmgren in
Google Scholar
PubMed
Search for other papers by Peter F Berglund in
Google Scholar
PubMed
Search for other papers by Birgitta Johansson in
Google Scholar
PubMed
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden
Gothenburg Centre for Person Centred-Care (GPCC), Göteborg, Sweden
Search for other papers by Helena Filipsson Nyström in
Google Scholar
PubMed
Hospital, Göteborg ( n = 64) and from the Department of Medicine at Kungälv’s Hospital, Kungälv ( n = 1) in Sweden. They were eligible for the study if they were premenopausal, with fT4 levels ≥50 pmol/L (reference range: 12–22) and/or total T3 ≥6.0 nmol
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Heleen I Jansen in
Google Scholar
PubMed
Search for other papers by Antonius E van Herwaarden in
Google Scholar
PubMed
Search for other papers by Henk J Huijgen in
Google Scholar
PubMed
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Rebecca C Painter in
Google Scholar
PubMed
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Search for other papers by Jacquelien J Hillebrand in
Google Scholar
PubMed
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Anita Boelen in
Google Scholar
PubMed
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Search for other papers by Annemieke C Heijboer in
Google Scholar
PubMed
/L at the lower or upper reference range ( 46 , 47 , 48 ). However, different fT4 IAs have varying techniques and reagent composition in measuring fT4 concentrations, meaning pregnancy does not influence all different IAs to the same extent as was
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Search for other papers by Kamilla R Riis in
Google Scholar
PubMed
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Search for other papers by Camilla B Larsen in
Google Scholar
PubMed
Search for other papers by Bjarke R Medici in
Google Scholar
PubMed
Search for other papers by Christian Z Jensen in
Google Scholar
PubMed
Search for other papers by Kristian H Winther in
Google Scholar
PubMed
Search for other papers by Emil L Larsen in
Google Scholar
PubMed
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Data and Data Support, Region Zealand, Sorø, Denmark
Search for other papers by Christina Ellervik in
Google Scholar
PubMed
Search for other papers by Jeppe L la Cour in
Google Scholar
PubMed
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Search for other papers by Laszlo Hegedüs in
Google Scholar
PubMed
Search for other papers by Thomas H Brix in
Google Scholar
PubMed
Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
Department of Cardiology, University Hospital Nordsjælland, Hillerød, Denmark
Search for other papers by Henrik E Poulsen in
Google Scholar
PubMed
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Search for other papers by Filip K Knop in
Google Scholar
PubMed
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Search for other papers by Birte Nygaard in
Google Scholar
PubMed
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Search for other papers by Steen J Bonnema in
Google Scholar
PubMed
the reference range of 0.3–4.0 mIU/L and total plasma thyroxine (TT4) below the reference range of 60–130 nmol/L) or mild (plasma TSH above the reference range, and plasma TT4 within the reference range). Exclusion criteria were pregnancy or planned
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Search for other papers by Stine Linding Andersen in
Google Scholar
PubMed
Search for other papers by Niels Henrik Bruun in
Google Scholar
PubMed
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Search for other papers by Peter Astrup Christensen in
Google Scholar
PubMed
Search for other papers by Simon Lykkeboe in
Google Scholar
PubMed
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Search for other papers by Aase Handberg in
Google Scholar
PubMed
Search for other papers by Annebirthe Bo Hansen in
Google Scholar
PubMed
Search for other papers by Maja Hjelm Lundgaard in
Google Scholar
PubMed
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Search for other papers by Louise Knøsgaard in
Google Scholar
PubMed
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Search for other papers by Nanna Maria Uldall Torp in
Google Scholar
PubMed
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Search for other papers by Allan Carlé in
Google Scholar
PubMed
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Search for other papers by Jesper Karmisholt in
Google Scholar
PubMed
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Search for other papers by Inge Bülow Pedersen in
Google Scholar
PubMed
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
Search for other papers by Peter Vestergaard in
Google Scholar
PubMed
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
Search for other papers by Stig Andersen in
Google Scholar
PubMed
evaluation of maternal thyroid function in early pregnancy is challenged by the physiological alterations in thyroid function and binding proteins associated with the pregnant state ( 7 ). Thus, pregnancy- and method-specific reference ranges are needed for
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Search for other papers by Carla Colombo in
Google Scholar
PubMed
Search for other papers by Daniele Ceruti in
Google Scholar
PubMed
Search for other papers by Massimiliano Succi in
Google Scholar
PubMed
Search for other papers by Simone De Leo in
Google Scholar
PubMed
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
Search for other papers by Matteo Trevisan in
Google Scholar
PubMed
Search for other papers by Claudia Moneta in
Google Scholar
PubMed
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Search for other papers by Laura Fugazzola in
Google Scholar
PubMed
patients treated with VAN and white dots represent patients treated with SELP. Nine male patients (100%) and 11/17 (65%) female patients showed Δ4 androstenedione values below the median of the reference range (of which 10 patients below the 5th percentile
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain
Search for other papers by Berta Soldevila in
Google Scholar
PubMed
Department of Obstetrics & Gynecology, Germans Trias i Pujol University Hospital, Badalona, Spain
Search for other papers by Inés Velasco in
Google Scholar
PubMed
Search for other papers by Carla Muñoz in
Google Scholar
PubMed
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain
Search for other papers by Yesika Díaz in
Google Scholar
PubMed
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain
Search for other papers by Laia Egea-Cortés in
Google Scholar
PubMed
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Search for other papers by Laura Ferrer-Escopiñan in
Google Scholar
PubMed
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Search for other papers by Alejandra Pérez-Montes de Oca in
Google Scholar
PubMed
Search for other papers by Raquel Martínez-Mondejar in
Google Scholar
PubMed
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain
Search for other papers by Jordi Casabona in
Google Scholar
PubMed
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain
Search for other papers by Manel Puig-Domingo in
Google Scholar
PubMed
women differs from non-pregnant women, and current guidelines recommend to establish local reference ranges for thyroid hormone values during specific time points of pregnancy ( 6 ). Our group has recently described trimester-specific reference ranges
Search for other papers by Ladan Mehran in
Google Scholar
PubMed
Search for other papers by Atieh Amouzegar in
Google Scholar
PubMed
Search for other papers by Hengameh Abdi in
Google Scholar
PubMed
Search for other papers by Negar Delbari in
Google Scholar
PubMed
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Search for other papers by Elham Madreseh in
Google Scholar
PubMed
Search for other papers by Maryam Tohidi in
Google Scholar
PubMed
Search for other papers by Mohammad Ali Mansournia in
Google Scholar
PubMed
Search for other papers by Fereidoun Azizi in
Google Scholar
PubMed
. Definitions TDs were defined based on TSH (0.32–5.06 µ/L) and free thyroxin (FT4) (0.91–1.55 ng/dL) reference ranges previously calculated in the study population as the representative sample of Tehranian population [ 17 ]. TPOAB positivity is considered as
Search for other papers by Enrique Soto-Pedre in
Google Scholar
PubMed
Search for other papers by Moneeza K. Siddiqui in
Google Scholar
PubMed
Search for other papers by Ify Mordi in
Google Scholar
PubMed
Search for other papers by Cyrielle Maroteau in
Google Scholar
PubMed
Search for other papers by Jimena Soto-Hernaez in
Google Scholar
PubMed
Search for other papers by Colin N.A. Palmer in
Google Scholar
PubMed
Search for other papers by Ewan R. Pearson in
Google Scholar
PubMed
Department of Endocrinology and Diabetes, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
Search for other papers by Graham P. Leese in
Google Scholar
PubMed
-based genetic risk score; GoDARTS, Genetics of Diabetes and Audit Research Tayside Study. For all participants with a serum TSH in the reference range ( n = 9,452), we confirmed the association of serum TSH with known loci previously reported at CAPZB
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by Carolina C.P.S. Janovsky in
Google Scholar
PubMed
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by Rui M.B. Maciel in
Google Scholar
PubMed
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by Cleber P. Camacho in
Google Scholar
PubMed
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by Rosalia P. Padovani in
Google Scholar
PubMed
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by Claudia C. Nakabashi in
Google Scholar
PubMed
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by Ji H. Yang in
Google Scholar
PubMed
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by Eduardo Z. Malouf in
Google Scholar
PubMed
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by Elza S. Ikejiri in
Google Scholar
PubMed
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by M. Conceição O.C. Mamone in
Google Scholar
PubMed
Search for other papers by Jairo Wagner in
Google Scholar
PubMed
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by Danielle M. Andreoni in
Google Scholar
PubMed
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Search for other papers by Rosa Paula M. Biscolla in
Google Scholar
PubMed
sensitivities of 0.1 ng/ml. Anti-Tg was measured using a chemiluminescent immunometric assay until 2009 (reference range, 0-5 IU/ml). Afterwards, an indirect electrochemiluminescent immunoassay (reference range, 0-115 IU/ml; Roche®) was used. TSH was