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Medical Education Center, Hamamatsu University School of Medicine, Shizuoka, Japan
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Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan
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-old Japanese man with no family history of benign or malignant thyroid neoplasms, and without exposure to radiation, was found to have a nodule on the right lobe of his thyroid gland from ultrasonography (US) during an annual checkup. Fine-needle aspiration
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Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy
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Endocrine Unit, Azienda Ospedaliero-Universitaria di Ferrara, Cona/Ferrara, Italy
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Background: BRAFV600E (c.1799T>A) somatic mutation evaluation in fine needle aspiration biopsies (FNAB) is a powerful diagnostic tool in the settings of papillary thyroid cancer (PTC). However, its prognostic value is still a matter of great debate and has been addressed mostly in retrospective studies. Objectives: To evaluate whether the somatic BRAFV600E mutation, assessed by direct sequencing in FNAB material of thyroid nodules, may correlate with disease persistence in PTC patients. Study Design: We conducted a prospective cohort study investigating 160 PTC patients previously assessed for the somatic BRAFV600E mutation, and submitted to total thyroidectomy, with a follow-up of 2–10 years. Patients were matched according to somatic BRAFV600E mutation (80 BRAF+ and 80 BRAF– patients) and to the presence (LN+, 40 patients each group) or absence (LN, 40 patients each group) of neck lymphnode metastases. Disease persistence was considered according to basal or TSH-stimulated Thyroglobulin (TG) levels, anti-TG antibodies, neck ultrasound, CT scan where applicable and whole body scan after radioiodine ablation treatment (RAI). Results: The presence of the somatic BRAFV600E mutation did not influence the indication for RAI. None of the enrolled patients showed disease recurrence or died due to disease-related causes. During follow-up, disease persistence did not correlate with the presence of somatic BRAFV600E mutation both in patients submitted to RAI nor in those treated more conservatively. Conclusions: The somatic BRAFV600E mutation does not associate with a worse prognosis in low risk PTC and, in our settings, may not be considered an independent risk factor for disease persistence.
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thyroid-stimulating hormone, colonoscopy, and mammography screening. In our series, the sensitivity of serum Ctn was higher than that of cytology by fine-needle aspiration, as reported by others [ 6 , 13 - 16 ]. As a matter of fact, on fine-needle
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ultrasonographic features present honeycomb-like multiple small cysts in the thyroid gland. Discussion The strategic value of ultrasound as well as fine-needle aspiration biopsy cytology in preoperative surgical planning of patients with thyroid
Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University Sejong Hospital, Sejong, Republic of Korea
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Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea
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Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea
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should be considered in order to apply AS more precisely. Materials and methods Patients From January 2005 to April 2021, patients who were diagnosed with PTMC through preoperative fine-needle aspiration biopsy and underwent surgical treatment
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; FNA, fine-needle aspiration; FT3, free tri-iodothyronine; FT4, free thyroxine; Tg, thyroglobulin; TPO, thyroid peroxidase; TRAB, TSH receptor antibody; TSH, thyroid-stimulating hormone; US, ultrasound. Figure 2 Diagnostic workup and the
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School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland
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School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland
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School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland
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School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland
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School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland
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-guidancereportingthyroidcytology-jan16.html. 3 Cibas ES, Ali SZ: The Bethesda system for reporting thyroid cytopathology. Am J Clin Pathol 2009; 132:658–665. 10.1309/AJCPPHLWMI3JV4LA 19846805 4 Yang J, Schnadig V, Logrono R, et al: Fine-needle aspiration of thyroid
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NOVA Medical School
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macrocalcifications, the largest with 13 mm, in the thyroid gland and a heterogeneous and calcified nodule of 52 × 44 × 21 mm located in the right supraclavicular region. Fine-needle aspiration of a thyroid nodule and the supraclavicular nodule was suggestive of PTC
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Department of Medicine, University of Alcalá de Henares, Madrid
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IdiSNA (Instituto de investigación en la salud de Navarra), Pamplona, Spain
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treatment required for every thyroid nodule. This approach should compile information gathered from imaging techniques, cytological features, molecular tests, and artificial networks. FNA, fine-needle aspiration. Refining Cytological Analysis
Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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participated in the assessment, only the most experienced one was selected for the analysis. Both pathological examination of the surgical specimen and cytological examination of fine needle aspiration tissue were considered acceptable reference standards. A
