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Roberto Negro Division of Endocrinology, ‘V. Fazzi’ Hospital, Lecce, Italy

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their offspring when tested at age 3 years. This study involved 10 centers in the United Kingdom and 1 center in Italy (Turin), and has the merit of being one of the very few prospective studies of intervention for thyroid disease during pregnancy

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Mustafa Dinc Department of Internal Medicine, Beytepe Military Hospital

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Mustafa Cakar Departments of Internal Medicine, Ankara, Turkey

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Sevket Balta Cardiology, Gulhane Medical Academy, Ankara, Turkey

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Muharrem Akhan Departments of Internal Medicine, Ankara, Turkey

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Hakan Sarlak Departments of Internal Medicine, Ankara, Turkey

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Sait Demirkol Cardiology, Gulhane Medical Academy, Ankara, Turkey

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inspiration for further studies. Once-daily prenatal vitamins should contain 150-200 µg iodine. 250 µg daily iodine intake is recommended during pregnancy and in the lactation period. The adequacy of the iodine intake during pregnancy can be assessed by

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Flora Veltri Department of Endocrinology, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Kris Poppe Department of Endocrinology, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Introduction Pregnancy is a condition leading to an increased demand in thyroid hormones (TH), resulting from the fetal need (especially before 18–20 weeks), increased renal iodide loss, increased levels of serum thyroxine-binding globulin

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Hongcheng Wei State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Quanquan Guan State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Qiurun Yu State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Ting Chen Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Xu Wang Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China

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Yankai Xia State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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suggests that maternal thyroid function, acting as an essential biological indicator during pregnancy, plays a critical role in normal reproduction in several pathways, and thyroid dysfunction is among the most prevalent endocrine disorders during pregnancy

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Paolo Cavarzere Pediatric Division, Department of Pediatrics, University Hospital of Verona, Verona, Italy

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Laura Palma Pediatric Division, Department of Pediatrics, University Hospital of Verona, Verona, Italy

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Lara Nicolussi Principe Pediatric Division, Department of Pediatrics, University Hospital of Verona, Verona, Italy

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Monica Vincenzi Pediatric Section, Department Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
Regional Center for Newborn Screening, Diagnosis and Treatment of Congenital Metabolic and Endocrinological Diseases, Verona, Italy

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Silvana Lauriola Neonatal Intensive Cure Unit, Department of Pediatrics, University Hospital of Verona, Verona, Italy

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Rossella Gaudino Pediatric Division, Department of Pediatrics, University Hospital of Verona, Verona, Italy
Pediatric Section, Department Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy

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Virginia Murri Pediatric Division, Hospital of San Bonifacio, Verona, Italy

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Luigi Lubrano Pediatric Division, Hospital of Legnago, Verona, Italy

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Giuliana Rossi Pediatric Division, Hospital of Mestre, Venezia, Italy

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Alessia Sallemi Pediatric Division, Hospital of Venezia, Venezia, Italy

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Ermanna Fattori Pediatric Division, Hospital of Negrar, Verona, Italy

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Marta Camilot Pediatric Section, Department Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
Regional Center for Newborn Screening, Diagnosis and Treatment of Congenital Metabolic and Endocrinological Diseases, Verona, Italy

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Franco Antoniazzi Pediatric Division, Department of Pediatrics, University Hospital of Verona, Verona, Italy
Pediatric Section, Department Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
Regional Center for the Diagnosis and Treatment of Children and Adolescents Rare Skeletal Disorders, Pediatric Clinic, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy

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Introduction During pregnancy, normal thyroid function is essential to ensure the regular development of the fetus ( 1 , 2 ). Overt or subclinical maternal hypothyroidism can modify, in fact, the course of pregnancy and the development of the

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Marise Codeco de Andrade Barreto Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Natalia Treistman Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Lara Bessa Campelo Pinheiro Cavalcante Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Daniel Bulzico Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil

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Fernanda Accioly de Andrade Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil

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Rossana Corbo Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil

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Paulo Alonso Garcia Alves Junior Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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Fernanda Vaisman Department of Oncologic Endocrinology, Instituto Nacional de Câncer – INCA, Rio de Janeiro, RJ, Brazil
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil

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collected information included the participants’ age at menarche and menopause, pregnancy, age at first pregnancy, number of pregnancies, number of live births, congenital defects or health issues in the offspring, abortion, premature birth, date of last

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Yi Pan Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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Kathleen L. Caldwell Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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Yan Li Joint Program in Survey Methodology, University of Maryland, College Park, Md., USA

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Samuel P. Caudill Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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Mary E. Mortensen Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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Amir Makhmudov Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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Robert L. Jones Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga

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development and is the most common cause of preventable mental retardation in the world [ 4 , 8 ]. During pregnancy and early infancy, iodine deficiency can cause irreversible effects [ 4 ]. Major consequences of insufficient iodine intake are irreversible

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Véronique Raverot Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Centre de biologie et de pathologie Est, Lyon, France

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Stéphanie Metrat Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Centre de biologie et de pathologie Est, Lyon, France

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Pauline Perrin Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Centre de biologie et de pathologie Est, Lyon, France

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Juliette Abeillon Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Lyon, France

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Hélène Lasolle Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Lyon, France

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levels were 43 and 41 mUI/L, and free T4 were 11.2 and 11.7 pmol/L, respectively. The pregnancy went well, and the patient gave birth to a healthy baby. After pregnancy, levothyroxine was discontinued. Ten years after the first thyroid function test, TSH

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John H. Lazarus Thyroid Research Group, Institute of Molecular and Experimental Medicine, Cardiff University, University Hospital of Wales, Cardiff, UK

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childhood development. For example, mild-to-moderate iodine deficiency in the first trimester of pregnancy was associated with increased odds of the intelligence quotient of offspring being in the lowest quartile (odds ratio: 1.43; 95% CI: 1.04-1.98; p = 0

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Tanvir Rizvi Nuclear Medicine Division, Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Va., USA

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Patrice K. Rehm Nuclear Medicine Division, Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Va., USA

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other abnormalities were present and the ovaries were left at the time of hysterectomy. Of note, the patient did not report of any complications during her two previous successful pregnancies. In September 2012 she underwent a Thyrogen protocol, with

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