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their offspring when tested at age 3 years. This study involved 10 centers in the United Kingdom and 1 center in Italy (Turin), and has the merit of being one of the very few prospective studies of intervention for thyroid disease during pregnancy
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inspiration for further studies. Once-daily prenatal vitamins should contain 150-200 µg iodine. 250 µg daily iodine intake is recommended during pregnancy and in the lactation period. The adequacy of the iodine intake during pregnancy can be assessed by
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Introduction Pregnancy is a condition leading to an increased demand in thyroid hormones (TH), resulting from the fetal need (especially before 18–20 weeks), increased renal iodide loss, increased levels of serum thyroxine-binding globulin
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
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Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
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Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
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Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
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suggests that maternal thyroid function, acting as an essential biological indicator during pregnancy, plays a critical role in normal reproduction in several pathways, and thyroid dysfunction is among the most prevalent endocrine disorders during pregnancy
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Regional Center for Newborn Screening, Diagnosis and Treatment of Congenital Metabolic and Endocrinological Diseases, Verona, Italy
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Pediatric Section, Department Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
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Regional Center for Newborn Screening, Diagnosis and Treatment of Congenital Metabolic and Endocrinological Diseases, Verona, Italy
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Pediatric Section, Department Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
Regional Center for the Diagnosis and Treatment of Children and Adolescents Rare Skeletal Disorders, Pediatric Clinic, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
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Introduction During pregnancy, normal thyroid function is essential to ensure the regular development of the fetus ( 1 , 2 ). Overt or subclinical maternal hypothyroidism can modify, in fact, the course of pregnancy and the development of the
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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collected information included the participants’ age at menarche and menopause, pregnancy, age at first pregnancy, number of pregnancies, number of live births, congenital defects or health issues in the offspring, abortion, premature birth, date of last
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development and is the most common cause of preventable mental retardation in the world [ 4 , 8 ]. During pregnancy and early infancy, iodine deficiency can cause irreversible effects [ 4 ]. Major consequences of insufficient iodine intake are irreversible
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levels were 43 and 41 mUI/L, and free T4 were 11.2 and 11.7 pmol/L, respectively. The pregnancy went well, and the patient gave birth to a healthy baby. After pregnancy, levothyroxine was discontinued. Ten years after the first thyroid function test, TSH
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childhood development. For example, mild-to-moderate iodine deficiency in the first trimester of pregnancy was associated with increased odds of the intelligence quotient of offspring being in the lowest quartile (odds ratio: 1.43; 95% CI: 1.04-1.98; p = 0
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other abnormalities were present and the ovaries were left at the time of hysterectomy. Of note, the patient did not report of any complications during her two previous successful pregnancies. In September 2012 she underwent a Thyrogen protocol, with