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Leonidas Duntas Evgenideion Hospital, Unit of Endocrinology, Diabetes and Metabolism, National and Kapodeistrian University of Athens, Greece

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parameters while also replying to the question of whether long-term Se supplementation can reverse the progression of disease in early-stage autoimmune thyroiditis. It has long been known that the thyroid is essential for the maintenance of overall body

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Kristian Hillert Winther Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Enrico Papini Department of Endocrinology and Metabolism, Ospedale Regina Apostolorum, Rome, Italy

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Roberto Attanasio Endocrine Unit, IRCCS Galeazzi Institute, Milan, Italy

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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ETA clinical guidelines. Ongoing large-scale trials [ 18 , 34 ] may further clarify whether Se, an environmental factor in interplay with genetic susceptibility to autoimmune thyroid diseases [ 9 , 35 - 37 ], translates into a role of Se

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Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Stig Andersen Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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.1089/thy.2018.0628 30734656 1050-7256 14 Feldt-Rasmussen U , Bliddal S , Rasmussen AK , Boas M , Hilsted L , Main K . Challenges in interpretation of thyroid function tests in pregnant women with autoimmune thyroid disease . J

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Kira Bang Bové Department of Endocrinology, Odense, Denmark

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Torquil Watt Department of Endocrinology, Odense, Denmark
Institute of Public Health, University of Copenhagen, Odense, Denmark

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Asmus Vogel Memory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Odense, Denmark

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Jakob Bue Bjoerner Institute of Public Health, University of Copenhagen, Odense, Denmark
National Research Centre for the Working Environment, Copenhagen, Odense, Denmark

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Mogens Groenvold Institute of Public Health, University of Copenhagen, Odense, Denmark
Department of Palliative Medicine, Bispebjerg Hospital, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Åse Krogh Rasmussen Department of Endocrinology, Odense, Denmark

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Ulla Feldt-Rasmussen Department of Endocrinology, Odense, Denmark

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Introduction Anxiety and depression are common mental disorders affecting the general population [ 1 ]. They are often found in patients with chronic somatic diseases, among these thyroid dysfunction [ 2 ]. Hypothyroidism has been linked to

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Francesco Boi Endocrinology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy

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Fabiana Pani Endocrinology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy

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Stefano Mariotti Endocrinology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy

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. References 1 Weetman AP: Autoimmune thyroid disease: propagation and progression. Eur J Endocrinol 2003;148: 1–9. 10.1530/eje.0.1480001 12534350 2 Tomer Y: Genetic dissection of familial autoimmune thyroid diseases using whole genome screening

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Pei-Wen Wang Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

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I-Ya Chen Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

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Suh-Hang Hank Juo Department of Medical Research, Kaohsiung Medical University Hospital and Graduate Institute of Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC

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Edward Hsi Department of Medical Research, Kaohsiung Medical University Hospital and Graduate Institute of Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC

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Rue-Tsuan Liu Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

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Ching-Jung Hsieh Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

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genome-wide scan in 56 [ 19 ] and 99 families [ 20 ] with autoimmune thyroid diseases. The three genes have overlapping and distinct functions in signaling pathways [ 21 ]. CD28 is expressed constitutively on CD4 T cells, and its ligand, the B7 family, is

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Meenu Gill Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Ashima Batra Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Ashok Sangwaiya Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Samta Shakya General Hospital, Sirsa, India

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Sumiti Gupta Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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Rajeev Sen Department of Pathology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak

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that PTLs typically occur in middle- to older-aged women and arise in the setting of autoimmune thyroiditis (lymphocytic thyroiditis, Hashimoto's disease) [ 1 ]. The term ‘primary' designates patients with lymphomatous involvement of the thyroid at

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N. Papanikolaou Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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P. Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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effect of hyperthyroidism or autoimmune processes. The latter include orbitopathy, goiter and thyroid dermopathy. Musculoskeletal complaints are common in patients with thyroid dysfunction. Patients suffering from Graves’ disease usually experience

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Christiaan F Mooij Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands

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Timothy D Cheetham Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UK
Department of Pediatric Endocrinology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK

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Frederik A Verburg Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands

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Anja Eckstein Department of Ophthalmology, University Duisburg Essen, Essen, Germany

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Simon H Pearce Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UK
Endocrine Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK

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Juliane Léger Department of Pediatric Endocrinology and Diabetes, Reference Center for Rare Endocrine Growth and Development Diseases, Endo-ERN HCP, Assistance Publique-Hôpitaux de Paris, Robert Debré University Hospital, University of Paris, NeuroDiderot Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France

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A S Paul van Trotsenburg Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands

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ultrasonography Biochemical characteristics Thyroid gland   Autoimmune   Graves’ disease Autoimmune disease characterized by the presence of TSHRAb stimulating the thyroid gland. May arise following interventions such as bone

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Saleha Babli Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada
Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia

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Richard J.  Payne Department of Otolaryngology, Royal Victoria Hospital, McGill University, Montreal, Québec, Canada

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Elliot Mitmaker Department of Surgery, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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Juan Rivera Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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Introduction Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising approximately 80% of all thyroid cancers [ 1 , 2 ]. Chronic lymphocytic thyroiditis (CLT) is an autoimmune disease characterized by widespread

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