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Alessandro Brancatella Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Laura Pierotti Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Nicola Viola Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Isabella Lupi Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Lucia Montanelli Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Chiara Cremolini Oncology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

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Paolo Piaggi Department of Information Engineering, University of Pisa, Pisa, Italy

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Antonio Chella Pneumology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy

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Andrea Antonuzzo Oncology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

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Daniele Sgrò Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Lucia Antonangeli Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Chiara Sardella Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Sandra Brogioni Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Claudio Marcocci Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Ferruccio Santini Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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Francesco Latrofa Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy

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). Reference ranges were 8–18 ng/dL for FT4, 2.5–5.0 ng/L for FT3 and 0.4–4 mIU/L for TSH. Tg was measured by an immunometric assay (Access Thyroglobulin assay; Beckman Coulter, Inc., Fullerton, CA, USA) (functional sensitivity 0.1 ng/mL). TgAbs were measured

Article Type:
Research Article
Collections:
Hyperthyroidism and thyrotoxicosis
DOI:
https://doi.org/10.1530/ETJ-22-0030
Volume/Issue:
Volume 11: Issue 4
Open access
Kenneth Ka Hei Lai Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China

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Fatema Mohamed Ali Abdulla Aljufairi Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Department of Ophthalmology, Salmaniya Medical Complex, Government Hospitals, Bahrain

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Jake Uy Sebastian Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Department of Ophthalmology, Vicente Sotto Memorial Medical Center, Cebu City, Philippines

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Yingying Wei Department of Statistics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China

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Ruofan Jia Department of Statistics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China

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Karen Kar Wun Chan Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China

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Elaine Yuen Ling Au Division of Clinical Immunology, Department of Pathology, Queen Mary Hospital, Hong Kong Special Administrative Region, China

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Alan Chun Hong Lee Division of Endocrinology and Metabolism, Department of Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region, China

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Chiu Ming Ng Department of Medicine, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China

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Hunter Kwok Lai Yuen Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Hong Kong Eye Hospital, Hong Kong Special Administrative Region, China

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Wilson Wai Kuen Yip Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China

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Alvin Lerrmann Young Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China

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George Pak Man Cheng Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China

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Clement Chee Yung Tham Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Hong Kong Eye Hospital, Hong Kong Special Administrative Region, China

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Chi Pui Pang Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China

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Kelvin Kam Lung Chong Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Hong Kong Eye Hospital, Hong Kong Special Administrative Region, China

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.4 MRD1 (mm) 5.3 ± 1.7 EOMy 1.8 ± 1.0 Diplopia 0.7 ± 0.8 Exophthalmos (mm) 19 ± 3 Mild^ 88 Moderate to severe^ 157 DON 10 (4%) *Reference range of TSH = 0.27 to 4.20 mIU/L; **Reference range of

Article Type:
Research Article
Collections:
Thyroid function tests
DOI:
https://doi.org/10.1530/ETJ-23-0129
Volume/Issue:
Volume 13: Issue 4
Open access
Pedro Weslley Souza Rosario Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Gabriela Franco Mourão Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Maria Regina Calsolari Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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thyroid hormone concentrations within the reference range [ 1 , 2 , 5 ]. In a recent editorial, Professor Wiersinga proposed to add the presence of thyroid disease for the diagnosis of SCH [ 5 ]. This new definition prevents the erroneous treatment of

Article Type:
Letter
DOI:
https://doi.org/10.1159/000441416
Volume/Issue:
Volume 4: Issue 4
Free access
Genfeng Yu Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Siyang Liu Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Cheng Song Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Qintao Ma Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Xingying Chen Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Yuqi Jiang Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Hualin Duan Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Yajun He Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Dongmei Wang Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Heng Wan Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Jie Shen Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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syndrome is defined as T3 levels below the lower limit of normal. However, we included in this study a population with FT3, FT4, and TSH, all within the reference range. Therefore, FT3/FT4 is superior to FT3 in a population with normal thyroid function

Article Type:
Research Article
Collections:
Metabolic and cardiovascular effects of thyroid hormone
DOI:
https://doi.org/10.1530/ETJ-23-0130
Volume/Issue:
Volume 13: Issue 1
Open access
Roberto Negro Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy

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Roberto Attanasio Endocrinology Service, Galeazzi Institute IRCCS, Milan, Italy

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Enrico Papini Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Rinaldo Guglielmi Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Franco Grimaldi Endocrinology and Metabolic Disease Unit, Azienda Ospedaliero-Universitaria “S. Maria della Misericordia”, Udine, Italy

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Vincenzo Toscano Endocrinology, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Roma, Italy

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Dan Alexandru  Niculescu Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania

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Diana Loreta  Paun Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania

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Catalina Poiana Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania

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of the normal reference range for a pregnant woman in the first trimester (TPOAb negative), whilst a quarter considered 4.0 mIU/L to be the upper limit of normal. The ATA suggestion to elevate the upper limit of TSH from 2.5 to 4.0 mIU/L is probably

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000490944
Volume/Issue:
Volume 7: Issue 6
Free access
Camille Galy-Bernadoy Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Benjamin Lallemant Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Guillaume Chambon Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Huy Trang Pham Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Christophe Reynaud Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Caroline Alovisetti Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Quentin Bonduelle Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Nîmes, Nîmes, France

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Anne Marie Guedj Department of Endocrinology and Metabolic Diseases, University Hospital of Nîmes, Nîmes, France

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Serge Lumbroso Department of Biochemistry and Molecular Biology, University Hospital of Nîmes, Nîmes, France

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David-Paul De Brauwere Department of Biochemistry and Molecular Biology, University Hospital of Nîmes, Nîmes, France

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variation, reference range, and functional sensitivity were respectively <2.6%, <5.8% (12–88 ng/L), and <4 ng/L. Elecsys 2010 Roche (Mannheim, Germany), whose intra-assay and inter-assay coefficient of variation, reference range, and functional

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000484689
Volume/Issue:
Volume 7: Issue 1
Free access
Renata Alencar Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil

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Daniel Barretto Kendler Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil

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Fernanda Andrade Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil

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Carla Nava Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil

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Daniel Bulzico Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil

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Cencita Cordeiro de Noronha Pessoa Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil

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Rossana Corbo Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil

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Fernanda Vaisman Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil

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prognosis even within the “reference range.” In the present study, the cutoff for CA19-9 was much lower than the one traditionally used for pancreatic tumors, suggesting that maybe, for MTC, a specific “reference range” should be established. In fact, the

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000497201
Volume/Issue:
Volume 8: Issue 4
Free access
Eyun Song Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Jonghwa Ahn Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Hye-Seon Oh Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Min Ji Jeon Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Gu Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Bae Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Young Kee Shong Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Tae Yong Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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97.5th percentile of the serum TSH levels of the reference population, as previously reported [ 10 ]. Serum fT4 was also measured using electrochemiluminescence immunoassay (E-Free T4 kit, Roche Diagnostics, Mannheim, Germany), and the reference range

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000499961
Volume/Issue:
Volume 8: Issue 4
Free access
Sujoy Ghosh Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Subhodip Pramanik Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Kaushik Biswas Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Kingshuk Bhattacharjee Biocon Limited, Bengaluru, India

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Rajib Sarkar School of Digestive and Liver Diseases, Kolkata, India

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Subhankar Chowdhury Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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Pradip Mukhopadhyay Department of Endocrinology and Metabolism, I.P.G.M.E&R, Kolkata, India

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25 subjects (M 8, F 17) with newly diagnosed hypothyroid (TSH >10 mU/L with FT4 below normal reference range) were included as “newly diagnosed hypothyroid group” (group B). The third group consisted of consecutive 25 follow-up subjects with

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000504218
Volume/Issue:
Volume 9: Issue 1
Free access
Rajesh Rajput Department of Endocrinology and Medicine Unit V, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, India

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Vaibhav Pathak Department of Endocrinology and Medicine Unit V, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, India

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and T4, with an increase in TSH with the weekly dose, but the mean TSH in both of our study groups remained within the reference range at all times. Pharmacogenomic studies have suggested that the polymorphism in genes for deiodinase enzyme may be

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000477348
Volume/Issue:
Volume 6: Issue 5
Free access