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George J. Kahaly Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany

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Luigi Bartalena Department of Medicine and Surgery, University of Insubria, Varese, Italy

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Lazlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Laurence Leenhardt Thyroid and Endocrine Tumors Unit, Pitié Salpêtrière Hospital, Sorbonne University, Paris, France

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Kris Poppe Endocrine Unit, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Simon H. Pearce Department of Endocrinology, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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non-lactating women. 1, ∅∅○○ 43 MMI is recommended during lactation, given the concerns about PTU-mediated hepatotoxicity. 1, ∅∅○○ The Elderly, Children and Adolescents, and Immune Reconstitution Elderly Although the incidence of GD

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Min Ji Jeon Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Gu Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Ki-Wook Chung Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Jung Hwan Baek Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Bae Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Young Kee Shong Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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dysfunction are relatively common. Furthermore, prostate cancer usually develops in the elderly. These suggest that prostate cancer could be the best disease context in which to apply AS [ 9 , 12 ]. Since most PTMCs also have a very indolent nature

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Peter N. Taylor Thyroid Research Group, Institute of Experimental and Molecular Medicine, School of Medicine, Cardiff University, Cardiff
London School of Hygiene and Tropical Medicine, London

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Bijay Vaidya Department of Endocrinology, Royal Devon and Exeter Hospital and Peninsula Medical School, Exeter, UK

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higher in the elderly [ 52 , 53 ] and lower doses are generally used in pregnancy. Table 3 shows case reports of agranulocytosis secondary to ATDs in pregnancy. Whilst most cases are secondary to PTU, this might reflect recent higher prescribing of PTU

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Emilio Fiore Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy

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Francesco Latrofa Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy

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Paolo Vitti Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy

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comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. J Clin Endocrinol Metab 1998;83:765-769. 10.1210/jc.83.3.765 9506723 18 Boukis MA, Koutras DA, Souvatzoglou A, Evangelopoulou A, Vrontakis M

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Rachelle P Mendoza Department of Pathology, University of Rochester Medical Center, Rochester, New York, USA

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Richard Cody Simon Department of Pathology, University of Chicago, Chicago, Illinois, USA

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Nicole A Cipriani Department of Pathology, University of Chicago, Chicago, Illinois, USA

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Tatjana Antic Department of Pathology, University of Chicago, Chicago, Illinois, USA

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of these thyroid nodules were in women and elderly, commonly detected incidentally during work up for other conditions ( 3 , 11 , 12 , 13 ). In this study, we specifically followed benign thyroid nodules and determined the incidence rate of repeat

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Jean-Charles Martin Centre de recherche en CardioVasculaire et Nutrition (C2VN), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Institut National pour la Santé Et la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Marseille, France

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Thierry Pourcher Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Guillaume Phan Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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Julien Guglielmi Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Caroline Crambes Pharmacie Centrale des Armées (PCA), Direction des Approvisionnements en produits de Santé des Armées, Fleury-les-Aubrais, France

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François Caire-Maurisier Pharmacie Centrale des Armées (PCA), Direction des Approvisionnements en produits de Santé des Armées, Fleury-les-Aubrais, France

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Dalila Lebsir Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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David Cohen Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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Clément Rosique Centre de recherche en CardioVasculaire et Nutrition (C2VN), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Institut National pour la Santé Et la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Marseille, France

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Lun Jing Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Maha Hichri Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Lisa Salleron Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Jacques Darcourt Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France

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Maamar Souidi Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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Marc Benderitter Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France

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thyroid and cardiovascular functions in elderly rats . Biochemistry and Biophysics Reports 2020 24 100816 . ( https://doi.org/10.1016/j.bbrep.2020.100816 ) 24 Theodoropoulou A Vagenakis AG Makri M & Markou KB . Thyroid hormone synthesis and

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Kamilla R Riis Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Camilla B Larsen Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Bjarke R Medici Department of Medicine, Copenhagen University Hospital – Herlev and Gentofte, Denmark

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Christian Z Jensen Department of Medicine, Copenhagen University Hospital – Herlev and Gentofte, Denmark

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Kristian H Winther Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Emil L Larsen Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark

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Christina Ellervik Department of Laboratory Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Data and Data Support, Region Zealand, Sorø, Denmark

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Jeppe L la Cour Department of Medicine, Copenhagen University Hospital – Herlev and Gentofte, Denmark

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Thomas H Brix Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Henrik E Poulsen Department of Endocrinology, Copenhagen University Hospital, Bispebjerg-Frederiksberg Hospital, Denmark
Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
Department of Cardiology, University Hospital Nordsjælland, Hillerød, Denmark

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Filip K Knop Department of Medicine, Copenhagen University Hospital – Herlev and Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Birte Nygaard Department of Medicine, Copenhagen University Hospital – Herlev and Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Steen J Bonnema Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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a reduced generation of ROS but may be counterbalanced by a diminished antioxidant capacity. Complexity is underlined by the observation that untreated hypothyroidism, unless severe, may benefit elderly people in terms of longevity ( 30 ), although

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Tommaso Piticchio Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland

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Gilles Russ Department of Thyroid and Endocrine Tumor Diseases, La Pitie-Salpetriere Hospital, 83 Bd de l’Hopital, Paris, France

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Maija Radzina Riga Stradins University, Radiology Research Laboratory, Riga, Latvia
University of Latvia, Faculty of Medicine, Riga, Latvia

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Francesco Frasca Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy

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Cosimo Durante Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Pierpaolo Trimboli Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland

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Introduction Thyroid nodules (TNs) are frequently found in the general population, especially among women and the elderly. Research has observed TNs in up to 70% of screened adults, with around 5% potentially harboring cancer ( 1

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Stefan Matei Constantinescu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Julien Hospel Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Chantal Daumerie Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Orsalia Alexopoulou Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Dominique Maiter Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Maria-Cristina Burlacu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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://doi.org/10.1111/j.1532-5415.1989.tb07279.x ) 17 Khan SR Peeters RP van Hagen PM Dalm D & Chaker L . Determinants and clinical implications of thyroid peroxidase antibodies in middle-aged and elderly individuals: the Rotterdam Study . Thyroid

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Paneeraq Noahsen Arctic Health Research Centre, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Ilisimatusarfik, University of Greenland, Nuuk, Greenland
National Board of Health, Nuuk, Greenland

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Karsten F Rex Arctic Health Research Centre, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Ilisimatusarfik, University of Greenland, Nuuk, Greenland
Department of Internal Medicine, Queen Ingrid’s Hospital, Nuuk, Greenland

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Inge Bülow Pedersen Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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Gert Mulvad Ilisimatusarfik, University of Greenland, Nuuk, Greenland
Queen Ingrid’s Health Care Centre, Nuuk, Greenland

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Hans Christian Florian-Sørensen Tasiilaq Health Care Center, Tasiilaq, Greenland

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Michael Lynge Pedersen Steno Diabetes Center Nuuk, Nuuk, Greenland

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Stig Andersen Arctic Health Research Centre, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Ilisimatusarfik, University of Greenland, Nuuk, Greenland
Department of Internal Medicine, Queen Ingrid’s Hospital, Nuuk, Greenland
Department of Geriatric Medicine, Aalborg University Hospital, Aalborg, Denmark

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-2368 ) 23 Laurberg P Pedersen KM Hreidarsson A Sigfusson N Iversen E Knudsen PR . Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark

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