Sara Donato
Sara Donato
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
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Helder Simões
Helder Simões
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
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) and is defined by the same histological criteria as for thyroid cancer [ 2 - 5 ]. Metastatic malignant SO has been described to occur in 5–6% of the cases, and metastases are usually located within the abdomen [ 2 ]. The most common malignancy in SO is
Noha Mukhtar
Noha Mukhtar
Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
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Hadeel Aljamei
Hadeel Aljamei
Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
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Abeer Aljomaiah
Abeer Aljomaiah
Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
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Yosra Moria
Yosra Moria
Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
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Ali S. Alzahrani
Ali S. Alzahrani
Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
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vast majority of those tumors are papillary thyroid cancer, and more than 70% are small in size and carry minimal risk for mortality [ 1 ]. Realizing these facts, many experts in the field proposed a change in the diagnostic and therapeutic approaches
Valentina M. Drozd
Valentina M. Drozd
The International Fund “Help for patients with radiation-induced thyroid cancer ‘Arnica’”, Minsk, Belarus
Project Chernobyl, Brooklyn, New York, USA
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Project Chernobyl, Brooklyn, New York, USA
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Igor Branovan
Igor Branovan
Project Chernobyl, Brooklyn, New York, USA
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Nikolay Shiglik
Nikolay Shiglik
Project Chernobyl, Brooklyn, New York, USA
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Johannes Biko
Johannes Biko
Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany
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Christoph Reiners
Christoph Reiners
The International Fund “Help for patients with radiation-induced thyroid cancer ‘Arnica’”, Minsk, Belarus
Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany
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Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany
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rising more rapidly than that of any other malignancy except liver cancer [ 1 ], with the annual percent change (both genders) increasing from 2.4% in 1980–1997 to 6.6% in 1997–2009 [ 2 , 8 ]. In Europe, the increase in the last 2–3 decades has ranged
Yoon Young Cho
Yoon Young Cho
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Seoul, Republic of Korea
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Hye Won Jang
Hye Won Jang
Department of Medical Education, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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Ji Young Joung
Ji Young Joung
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Seoul, Republic of Korea
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Sun-Mi Park
Sun-Mi Park
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Seoul, Republic of Korea
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Dae Joon Jeong
Dae Joon Jeong
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Seoul, Republic of Korea
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Sun Wook Kim
Sun Wook Kim
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Seoul, Republic of Korea
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Jae Hoon Chung
Jae Hoon Chung
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Seoul, Republic of Korea
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Introduction Childhood thyroid cancer is a rare malignancy, but its incidence has been gradually increasing according to several epidemiologic studies [ 1 , 2 ]. An increase in the incidence of childhood thyroid cancer (aged 0-14 years) was
Furio Pacini
Furio Pacini
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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literature and expert opinion, the Guidelines come out with several recommendations dealing with standardization of the US scanning procedure, techniques and indications for US-guided fine-needle aspiration (US-FNA), classification of malignancy risk based on
Chantal A Lebbink
Chantal A Lebbink
Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands
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Thera P Links
Thera P Links
Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Agnieszka Czarniecka
Agnieszka Czarniecka
The Oncologic and Reconstructive Surgery Clinic, M. Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland
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Renuka P Dias
Renuka P Dias
Department of Paediatric Endocrinology and Diabetes, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, United Kingdom
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Louise Izatt
Louise Izatt
Department of Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, United Kingdom
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Heiko Krude
Heiko Krude
Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin, Berlin, Germany
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Kerstin Lorenz
Kerstin Lorenz
Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
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Markus Luster
Markus Luster
Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany
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Kate Newbold
Kate Newbold
Thyroid Therapy Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom
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Arnoldo Piccardo
Arnoldo Piccardo
Department of Nuclear Medicine, EO Ospedali Galliera, Genoa, Italy
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Manuel Sobrinho-Simões
Manuel Sobrinho-Simões
University Hospital of São João, Medical Faculty and Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
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Toru Takano
Toru Takano
Thyroid Center, Rinku General Medical Center, Osaka, Japan
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A S Paul van Trotsenburg
A S Paul van Trotsenburg
Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
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Frederik A Verburg
Frederik A Verburg
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
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Hanneke M van Santen
Hanneke M van Santen
Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands
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low recurrence rate and to minimize adverse effects of treatment) will be reached (4S). [B] Recommendations and suggestions for the pediatric thyroid nodule [B2] 3A 3B Risk of malignancy in thyroid nodule during childhood We recommend
Tamas Solymosi
Tamas Solymosi
Endocrinology and Metabolism Clinic, Bugat Hospital, Gyöngyös, Hungary
Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Laszlo Hegedűs
Laszlo Hegedűs
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Steen J Bonnema
Steen J Bonnema
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Andrea Frasoldati
Andrea Frasoldati
Endocrinology Unit of Arcispedale S Maria Nuova, Reggio Emilia, Italy
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Laszlo Jambor
Laszlo Jambor
Department of Radiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Zsolt Karanyi
Zsolt Karanyi
Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Gabor L Kovacs
Gabor L Kovacs
1st Department of Medicine, Flohr Ferenc Hospital, Kistarcsa, Hungary
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Enrico Papini
Enrico Papini
Regina Apostolorum Hospital in Albano, Rome, Italy
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Karoly Rucz
Karoly Rucz
1st Department of Medicine, University of Pecs, Pecs, Hungary
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Gilles Russ
Gilles Russ
Unité Thyroïde et Tumeurs Endocrines – Pr Leenhardt Hôpital La Pitie Salpetriere, Sorbonne Université, Paris, France
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Endre V Nagy
Endre V Nagy
Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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risk of malignancy (primarily papillary cancer) in thyroid lesions is significantly correlated to the presence of specific US features, which include hypoechogenicity, microcalcifications, taller than wide shape, irregular margins, and extrathyroidal
Sule Canberk
Sule Canberk
Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal
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Joana C. Ferreira
Joana C. Ferreira
Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Luísa Pereira
Luísa Pereira
Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
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Rui Batısta
Rui Batısta
Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Andre F. Vieira
Andre F. Vieira
Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Paula Soares
Paula Soares
Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
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Manuel Sobrinho Simões
Manuel Sobrinho Simões
Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal
Department of Pathology and Oncology, Centro Hospitalar São João, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal
Department of Pathology and Oncology, Centro Hospitalar São João, Porto, Portugal
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Valdemar Máximo
Valdemar Máximo
Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
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thyroid tumours associated with DICER1; 40% of the cases were syndromic (70/172) and 60% were non-syndromic (102/172) (online suppl. Table 1). In these 172 cases, the risk of malignancy was found to be 67% (47/70) and 75% (77/102) in the syndromic and non
Bernadette Biondi
Bernadette Biondi
Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
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Luigi Bartalena
Luigi Bartalena
Department of Clinical and Experimental Medicine, University of Insubria, Endocrine Unit, Ospedale di Circolo, Varese, Italy
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David S. Cooper
David S. Cooper
Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Md., USA
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Laszlo Hegedüs
Laszlo Hegedüs
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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Peter Laurberg
Peter Laurberg
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
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George J. Kahaly
George J. Kahaly
Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany
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risk of dementia in elderly patients with SHyper, and the mechanism is unclarified [ 54 , 55 , 56 , 57 , 58 ]. A recent systematic review provided evidence for an association between SHyper or low serum TSH within the reference range and cognitive
Lei Xu
Lei Xu
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China
Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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Junling Gao
Junling Gao
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China
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Quan Wang
Quan Wang
Laboratory of Surgical Oncology, Peking University People’s Hospital, Peking University, Beijing, China
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Jichao Yin
Jichao Yin
Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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Pengfei Yu
Pengfei Yu
Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Bin Bai
Bin Bai
Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Ruixia Pei
Ruixia Pei
Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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Dingzhang Chen
Dingzhang Chen
Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Guochun Yang
Guochun Yang
Xi’an Hospital of Traditional Chinese Medicine, Xi’an, China
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Shiqi Wang
Shiqi Wang
Xijing Hospital, Fourth Military Medical University, Xi’an, China
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Mingxi Wan
Mingxi Wan
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China
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suspicion, and the risk of malignancy of such nodules is exceedingly low [ 11 ]. In conclusion, our results suggest that CAD systems may provide an accuracy comparable to that of radiologists with 5–20 years of experience in thyroid ultrasound scanning
