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Tetsuya Hiraiwa Hiraiwa Thyroid Clinic, Ibaraki City
Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Naoyuki Tsujimoto Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Keiji Tanimoto Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Jungo Terasaki Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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Nobuyuki Amino Kuma Hospital, Kobe, Japan

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Toshiaki Hanafusa Department of Internal Medicine (I), Osaka Medical College, Takatsuki City

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laboratory tests showing high values of free thyroxine (FT 4 ) and free tri-iodothyronine (FT 3 ), low levels of thyrotropin-stimulating hormone (TSH), increased TSH receptor antibody (TRAb) titer and/or thyroid-associated ophthalmopathy. PT was diagnosed by

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000350560
Volume/Issue:
Volume 2: Issue 2
Free access
Georgiana Sitoris Endocrine Unit Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Flora Veltri Endocrine Unit Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Malika Ichiche Endocrine Unit Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Pierre Kleynen Endocrine Unit Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Jean-Philippe Praet Department of Internal Medicine, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Serge Rozenberg Department of Gynecology and Obstetrics, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Kris G Poppe Endocrine Unit Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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, demographic and obstetrical data are noted and systematically completed with a biological analysis including serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), TPOAb, and ferritin measurement. The ethnic background of the women is based on a

Article Type:
Research Article
Collections:
Thyroid and reproduction
DOI:
https://doi.org/10.1530/ETJ-21-0142
Volume/Issue:
Volume 11: Issue 2
Open access
Mathieu Spaas Department of Radiation Oncology, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium

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Brigitte Decallonne Department of Endocrinology and Internal Medicine, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium

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Annouschka Laenen Leuven Biostatistics and Statistical Bioinformatics Centre, Leuven, Belgium

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Jaak Billen Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium

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Sandra Nuyts Department of Radiation Oncology, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium

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without review by our institution’s Pathology Department. Based on the aforementioned risk categories, patients were selected for one of two possible TSH stimulation modalities prior to receiving RAI. Firstly, thyroid hormone withdrawal (THW) consisted

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000489849
Volume/Issue:
Volume 7: Issue 4
Free access
Luca Persani Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Georg Brabant Experimental and Clinical Endocrinology Medical Clinic I – University of Lübeck, Lübeck, Germany

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Mehul Dattani Genetics and Genomic Medicine Programme, UCL GOS Institute of Child Health, London, United Kingdom

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Marco Bonomi Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Ulla Feldt-Rasmussen Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Eric Fliers Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Annette Gruters Department for Pediatric Endocrinology and Diabetes, Charité University Medicine, Berlin, Germany
University Hospital Heidelberg, Heidelberg, Germany

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Dominique Maiter Department of Endocrinology and Nutrition, UCL Cliniques Saint-Luc, Brussels, Belgium

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Nadia Schoenmakers University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke’s Hospital and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, United Kingdom

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A.S. Paul van Trotsenburg Department of Pediatric Endocrinology, Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Introduction Central hypothyroidism (CeH) is a disorder characterized by defective thyroid hormone production due to insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland. This condition is the consequence of

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000491388
Volume/Issue:
Volume 7: Issue 5
Free access
Heleen I Jansen Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands

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Marije van Haeringen Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Department of Computer Science, Vrije Universiteit, Boelelaan, Amsterdam, The Netherlands

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Marelle J Bouva Reference Laboratory Neonatal Screening, Center for Health protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands

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Wendy P J den Elzen Department of Laboratory Medicine, Laboratory Specialized Diagnostics & Research, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Public Health, Amsterdam, The Netherlands

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Eveline Bruinstroop Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Endocrinology and Metabolism, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands

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Catharina P B van der Ploeg TNO - Child Health, Sylviusweg, Leiden, The Netherlands

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A S Paul van Trotsenburg Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands

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Nitash Zwaveling-Soonawala Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands

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Annemieke C Heijboer Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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Annet M Bosch Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Pediatrics, Division of Metabolic Disorders, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands

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Robert de Jonge Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit, Boelelaan, Amsterdam, The Netherlands
Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands

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Mark Hoogendoorn Department of Computer Science, Vrije Universiteit, Boelelaan, Amsterdam, The Netherlands

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Anita Boelen Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands

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) concentration in combination with an increased thyroid-stimulating hormone (TSH) concentration, while central CH is characterized by a low T4 concentration and a normal, decreased, or slightly elevated TSH concentration ( 1 ). The Dutch newborn screening (NBS

Article Type:
Research Article
Collections:
Pediatric thyroid diseases
DOI:
https://doi.org/10.1530/ETJ-23-0141
Volume/Issue:
Volume 12: Issue 6
Open access
Nianting Ju Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Liying Hou Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Hongjun Song Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zhongling Qiu Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yang Wang Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zhenkui Sun Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Quanyong Luo Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Chentian Shen Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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have a good prognosis due to the biological behavior and standard treatments. Three conventional treatment regimens for thyroid cancer are surgery, radioiodine ( 131 I) therapy, and thyroid-stimulating hormone (TSH) suppression. Among them, 131 I is

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-22-0219
Volume/Issue:
Volume 12: Issue 4
Open access
Jan Debeij Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden

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Suzanne C. Cannegieter Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden

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Bregje van Zaane Departments of Internal Medicine, Slotervaart Hospital
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands

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Anton P. van Zanten Departments of Clinical Biochemistry, Slotervaart Hospital

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Frits R. Rosendaal Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden

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Victor E.A. Gerdes Departments of Internal Medicine, Slotervaart Hospital
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands

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Pieter H. Reitsma Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden

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Olaf M. Dekkers Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Endocrinology and Metabolism, Leiden University Medical Centre, Leiden

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controls, while levothyroxine treatment was only present in controls. Laboratory Measurements Levels of fT 4 , thyroid-stimulating hormone (TSH) and thyroid peroxidase antibodies (anti-TPO) were measured in the available citrated plasma samples (103

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000357578
Volume/Issue:
Volume 3: Issue 1
Free access
Irene Campi Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Marco Dell’Acqua Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Elisa Stellaria Grassi Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Maria Cristina Vigone Department of Paediatrics, IRCCS San Raffaele Hospital, Milan, Italy

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Luca Persani Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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hypothyroidism include cardiovascular morbidity and increased mortality ( 3 , 4 ), several Scientific Societies recommend to measure circulating thyroid-stimulating hormone (TSH) in patients at risk. Iodine deficiency is still a common cause of

Article Type:
Review Article
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1530/ETJ-23-0012
Volume/Issue:
Volume 12: Issue 4
Open access
Simon H.S. Pearce Institute of Genetic Medicine, Newcastle University
Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Georg Brabant Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

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Leonidas H. Duntas Endocrine Unit, Evgenidion Hospital, University of Athens, Athens, Greece

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Fabio Monzani Department of Clinical and Experimental Medicine, Università di Pisa, Pisa, Italy

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Robin P. Peeters Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Salman Razvi Institute of Genetic Medicine, Newcastle University
Queen Elizabeth Hospital, Gateshead, UK

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Jean-Louis Wemeau Clinique Endocrinologique Marc Linquette, CHU, Lille, France

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Introduction Subclinical hypothyroidism (SCH) is defined as a state of increased serum thyroid-stimulating hormone (TSH) levels, with circulating thyroxine (T 4 ) and tri-iodothyronine (T 3 ) concentrations within the population reference

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000356507
Volume/Issue:
Volume 2: Issue 4
Free access
Kerstin Krause Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Juliane Weiner Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Sebastian Hönes Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Nora Klöting Division of Endocrinology and Nephrology, Department of Medicine, Germany
IFB Adiposity Diseases, Leipzig University Medical Centre, Leipzig, Germany

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Eddy Rijntjes Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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John T. Heiker Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Claudia Gebhardt Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Josef Köhrle Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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Dagmar Führer Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Karen Steinhoff Department of Nuclear Medicine, University of Leipzig, Germany

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Swen Hesse Department of Nuclear Medicine, University of Leipzig, Germany
IFB Adiposity Diseases, Leipzig University Medical Centre, Leipzig, Germany

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Lars C. Moeller Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Anke Tönjes Division of Endocrinology and Nephrology, Department of Medicine, Germany

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Introduction Thyroid hormones (TH) regulate a variety of physiological processes, including growth and development, and are potent regulators of metabolism throughout life [ 1 , 2 ]. TH status correlates with body weight and energy expenditure

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000437304
Volume/Issue:
Volume 4: Issue 1_Suppl
Free access