Andrea Palermo
Andrea Palermo
Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy
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Andrea Napolitano
Andrea Napolitano
Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy
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Daria Maggi
Daria Maggi
Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy
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Anda Mihaela Naciu
Anda Mihaela Naciu
Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy
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Gaia Tabacco
Gaia Tabacco
Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy
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Silvia Manfrini
Silvia Manfrini
Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy
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Anna Crescenzi
Anna Crescenzi
Department of Anatomic Pathology, Campus Bio-Medico University, Rome, Italy
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Chiara Taffon
Chiara Taffon
Department of Anatomic Pathology, Campus Bio-Medico University, Rome, Italy
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Francesco Pantano
Francesco Pantano
Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy
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Bruno Vincenzi
Bruno Vincenzi
Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy
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Guiseppe Tonini
Guiseppe Tonini
Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy
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Daniele Santini
Daniele Santini
Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy
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follow-up neck US, in which a significant volumetric increase in the nodule was detected (dimensions of 14 × 10 × 18 mm, vol 1.3 mL) (Fig. 2 a), and fine needle aspiration was performed. Cytological smears showed scanty atypical thyrocytes in a bloody
Kristine Z Swan
Kristine Z Swan
Department of ORL, Head- and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark
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Johnson Thomas
Johnson Thomas
Department of Endocrinology, Mercy Hospital, Springfield, Missouri, USA
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Viveque E Nielsen
Viveque E Nielsen
Department of ORL, Head- and Neck Surgery, Odense University Hospital, Odense, Denmark
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Marie Louise Jespersen
Marie Louise Jespersen
Department of Pathology, Aarhus University Hospital, Aarhus, Denmark
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Steen J Bonnema
Steen J Bonnema
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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based on ultrasound images collected retrospectively from a different institution. The secondary aim was to assess the performance of AIBx applied to thyroid nodules with indeterminate cytology. Materials and methods This was a single
Furio Pacini
Furio Pacini
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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methodological issues, such as the need for an experienced US operator, careful inspection of all lymph node chains (from level II to level VI), standardization of the method for US-FNA of suspicious nodes for both cytology and Tg measurement (or calcitonin in
Rachelle P Mendoza
Rachelle P Mendoza
Department of Pathology, University of Rochester Medical Center, Rochester, New York, USA
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Richard Cody Simon
Richard Cody Simon
Department of Pathology, University of Chicago, Chicago, Illinois, USA
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Nicole A Cipriani
Nicole A Cipriani
Department of Pathology, University of Chicago, Chicago, Illinois, USA
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Tatjana Antic
Tatjana Antic
Department of Pathology, University of Chicago, Chicago, Illinois, USA
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Introduction Fine needle aspiration cytology (FNA) is widely accepted as the most accurate and cost-effective diagnostic procedure in the assessment of thyroid nodules. The Bethesda System outlines the diagnostic categories for thyroid nodules
Satoshi Koyama
Satoshi Koyama
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan
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Naritomo Miyake
Naritomo Miyake
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan
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Kazunori Fujiwara
Kazunori Fujiwara
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan
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Tsuyoshi Morisaki
Tsuyoshi Morisaki
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan
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Takahiro Fukuhara
Takahiro Fukuhara
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan
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Hiroya Kitano
Hiroya Kitano
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan
Center for Head and Neck Surgery, Kusatsu General Hospital, Kusatsu, Japan
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Center for Head and Neck Surgery, Kusatsu General Hospital, Kusatsu, Japan
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Hiromi Takeuchi
Hiromi Takeuchi
Department of Otolaryngology Head and Neck Surgery, Tottori University Faculty of Medicine, Yonago, Japan
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-needle aspiration cytology. Liquid-based cytology and cell block cytology techniques were combined with the conventional technique. Only case 5 was histologically diagnosed using lymph node biopsy because of insufficient information from fine-needle aspiration
Mitsuaki Tokumaru
Mitsuaki Tokumaru
Department of Internal Medicine, Enshu Hospital, Hamamatsu, Japan
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Kenji Ohba
Kenji Ohba
Department of Internal Medicine, Enshu Hospital, Hamamatsu, Japan
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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Kennichi Kakudo
Kennichi Kakudo
Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Izumi, Japan
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Takafumi Suda
Takafumi Suda
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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Yutaka Oki
Yutaka Oki
Department of Family and Community Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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Yoshie Goto
Yoshie Goto
Department of Internal Medicine, Enshu Hospital, Hamamatsu, Japan
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border was well defined, and its margin showed a broccoli-like growth pattern. Based on US findings (Fig. 1 a, b), we initially suspected thyroid lymphoma [ 5 ]; however, fine-needle aspiration cytology (FNAC) findings revealed the benign cytological
Hélène Théodon
Hélène Théodon
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Erell Guillerm
Erell Guillerm
Department of Oncogenetic, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Johanna Wassermann
Johanna Wassermann
Department of Oncology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Gabrielle Deniziaut
Gabrielle Deniziaut
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Loïc Jaffrelot
Loïc Jaffrelot
Department of Oncology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Jérome Denis
Jérome Denis
Department of Endocrine and Oncology Biochemistry, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris, France
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Nathalie Chereau
Nathalie Chereau
Department of Endocrine Surgery, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Claude Bigorgne
Claude Bigorgne
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Wiame Potonnier
Wiame Potonnier
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Florence Coulet
Florence Coulet
Department of Oncogenetic, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Laurence Leenhardt
Laurence Leenhardt
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Camille Buffet
Camille Buffet
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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surgery ( n = 1) A non-metastatic neck lymph node or mass ( n = 19) In total, 34 DNA and/or RNA-based NGS analyses were included, performed on cytologically proven recurrent thyroid cancer metastatic neck lymph nodes or masses ( Fig. 1
Gilles Russ
Gilles Russ
Thyroid and Endocrine Tumor Unit, Department of Nuclear Medicine, Pitié Salpêtrière Hospital, University Pierre et Marie Curie, Paris, France
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Sophie Leboulleux
Sophie Leboulleux
Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, University Paris-Sud, Villejuif, France
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Laurence Leenhardt
Laurence Leenhardt
Thyroid and Endocrine Tumor Unit, Department of Nuclear Medicine, Pitié Salpêtrière Hospital, University Pierre et Marie Curie, Paris, France
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Laszlo Hegedüs
Laszlo Hegedüs
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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simplify the system designed by Park et al. [ 30 ] in a multicenter retrospective study of 1,658 nodules >10 mm, 298 of which were surgically removed. The total number of cytologically indeterminate nodules is not available, but all the ones retained in the
L. Leenhardt
L. Leenhardt
Department of Nuclear Medicine, Pitié Salpêtrière Hospital, Cancer Institute, Pierre et Marie Curie University, Paris, France
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M.F. Erdogan
M.F. Erdogan
Department of Endocrinology and Metabolism, University of Ankara School of Medicine, İbni Sina Hastanesi, Ankara, Turkey
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L. Hegedus
L. Hegedus
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
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S.J. Mandel
S.J. Mandel
Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa., USA
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R. Paschke
R. Paschke
Department of Endocrinology, University of Leipzig, Leipzig, Germany
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T. Rago
T. Rago
Endocrine Unit 1, Department of Internal Medicine, Ospedale Cisanello, University of Pisa, Pisa, Italy
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G. Russ
G. Russ
Department of Nuclear Medicine, Pitié Salpêtrière Hospital, Cancer Institute, Pierre et Marie Curie University, Paris, France
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tip. For LNs with mixed content and a significant solid portion, the needle should target the solid portion for cytology assessment and the fluid can be aspirated for Tg measurement and also for cytological study after centrifugation. A 24- to 27-gauge
Zoë Y.G.J. van Lierop
Zoë Y.G.J. van Lierop
Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands
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Sander Jentjens
Sander Jentjens
Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
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Monique H.M.E. Anten
Monique H.M.E. Anten
Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands
Neurofibromatosis Expert Team, Maastricht University Medical Centre, Maastricht, The Netherlands
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Neurofibromatosis Expert Team, Maastricht University Medical Centre, Maastricht, The Netherlands
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Roel Wierts
Roel Wierts
Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
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Connie T. Stumpel
Connie T. Stumpel
Neurofibromatosis Expert Team, Maastricht University Medical Centre, Maastricht, The Netherlands
Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
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Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
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Bas Havekes
Bas Havekes
Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
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Marinus J.P.G. van Kroonenburgh
Marinus J.P.G. van Kroonenburgh
Neurofibromatosis Expert Team, Maastricht University Medical Centre, Maastricht, The Netherlands
Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
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Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
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clinical information on possible thyroid disease. Reports on thyroid US were collected, as were fine-needle aspiration cytology, histology after (hemi) thyroidectomy, and FT4 and/or TSH levels that were measured closest to the time of the first PET/CT scan
