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Developmental Endocrinology Research Group, Institute of Child Health, University College London, London, UK
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) as a biomarker. Screening results for CH are considered positive when the bloodspot TSH concentration exceeds 20 mU/l and borderline when the concentration ranges between 10 and 20 mU/l [ 2 ]. A repeat bloodspot is taken 1 week later in cases of
Project Chernobyl, Brooklyn, New York, USA
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Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany
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have nitrate concentration exceeding the World Health Organization (WHO)-recommended maximum contaminant level of 45 mg/L [ 43 ]. In contrast, about 40% of water samples from open wells exceed that maximum contaminant level. In Brest and Gomel Oblasts
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
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1 * ^ We recommend that the diagnosis of CeH should be considered in every subject with low serum concentrations of FT4 and low or normal TSH on a screening examination. Strength of recommendation: 1; Level of evidence
Department of Clinical Sciences, Lund University, Lund
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Department of Clinical Sciences, Lund University, Lund
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, plasma concentrations of TSH <0.2 mIU/l, and increased plasma levels of free T 4 and/or free T 3 . The patients were classified as having GD on the basis of clinical signs, the presence of TSH receptor antibodies (TRAb) and/or a diffuse uptake on thyroid
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evident in severe Se and iodine-deficient areas [ 13 ], but may also be detectable in marginal Se deficiency countries [ 14 ], as is the case in most of Europe. In patients with autoimmune thyroid disease, including GD, plasma Se and GPx concentrations
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]. Due to the capacity of metastatic thyroid cells to take up iodine from blood, distant metastases from PTC, which are relatively uncommon, can sometimes be detected during a post-therapy whole-body iodine scan (WBI) performed after treatment with
Department of Ophthalmology, University Hospital Essen, Essen, Germany
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significant inverse correlation between serum Se and TRAK concentrations (fig. 3 b; R 2 = 0.061; p = 0.024). In comparison, IGF1R-aAB were present in about 10% of serum samples. IGF1R-aAB levels were neither related to serum SePP (fig. 3 c) nor to serum Se
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Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
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Introduction The large majority of patients with non-medullary thyroid carcinoma (NMTC) have an excellent prognosis and achieve remission after conventional treatment by surgery, radioactive iodine (RAI) treatment, and levothyroxine
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/l), progressive eye-lid and conjunctival swelling of the left eye (CAS > 3) with proptosis and motility restriction appeared. The TSHR-Ab concentration remained elevated at 5.7 U/l (Medipan, with cutoff <2.5 U/l), but comparable to levels before the administration
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urinary iodine excretion on random urinary samples of 30 subjects using the ion-selective electrode method on a Thermo-Orion Model 720A Instrument [ 23 ]. The inter- and intra-assay CVs were <10%. During pregnancy, median urinary iodine concentrations of