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Shirley Langham Departments of Endocrinology, Great Ormond Street Hospital, Hospital for Children

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Peter Hindmarsh Developmental Endocrinology Research Group, Institute of Child Health, University College London, London, UK

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Steven Krywawych Departments of Chemical Pathology, Great Ormond Street Hospital, Hospital for Children

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Catherine Peters Departments of Endocrinology, Great Ormond Street Hospital, Hospital for Children
Developmental Endocrinology Research Group, Institute of Child Health, University College London, London, UK

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) as a biomarker. Screening results for CH are considered positive when the bloodspot TSH concentration exceeds 20 mU/l and borderline when the concentration ranges between 10 and 20 mU/l [ 2 ]. A repeat bloodspot is taken 1 week later in cases of

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Valentina M. Drozd The International Fund “Help for patients with radiation-induced thyroid cancer ‘Arnica’”, Minsk, Belarus
Project Chernobyl, Brooklyn, New York, USA

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Igor Branovan Project Chernobyl, Brooklyn, New York, USA

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Nikolay Shiglik Project Chernobyl, Brooklyn, New York, USA

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Johannes Biko Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany

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Christoph Reiners The International Fund “Help for patients with radiation-induced thyroid cancer ‘Arnica’”, Minsk, Belarus
Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany

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have nitrate concentration exceeding the World Health Organization (WHO)-recommended maximum contaminant level of 45 mg/L [ 43 ]. In contrast, about 40% of water samples from open wells exceed that maximum contaminant level. In Brest and Gomel Oblasts

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Luca Persani Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Georg Brabant Experimental and Clinical Endocrinology Medical Clinic I – University of Lübeck, Lübeck, Germany

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Mehul Dattani Genetics and Genomic Medicine Programme, UCL GOS Institute of Child Health, London, United Kingdom

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Marco Bonomi Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Ulla Feldt-Rasmussen Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Eric Fliers Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Annette Gruters Department for Pediatric Endocrinology and Diabetes, Charité University Medicine, Berlin, Germany
University Hospital Heidelberg, Heidelberg, Germany

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Dominique Maiter Department of Endocrinology and Nutrition, UCL Cliniques Saint-Luc, Brussels, Belgium

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Nadia Schoenmakers University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke’s Hospital and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, United Kingdom

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A.S. Paul van Trotsenburg Department of Pediatric Endocrinology, Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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1 * ^ We recommend that the diagnosis of CeH should be considered in every subject with low serum concentrations of FT4 and low or normal TSH on a screening examination. Strength of recommendation: 1; Level of evidence

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Mikael Lantz Department of Endocrinology and Ophthalmology, Skåne University Hospital Malmö, Malmö
Department of Clinical Sciences, Lund University, Lund

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Jan Calissendorff Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset

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Frank Träisk Department of Clinical Neurosciences, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden

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Leif Tallstedt Department of Clinical Neurosciences, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden

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Tereza Planck Department of Endocrinology and Ophthalmology, Skåne University Hospital Malmö, Malmö
Department of Clinical Sciences, Lund University, Lund

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Ove Törring Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset

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Bengt Hallengren Department of Endocrinology and Ophthalmology, Skåne University Hospital Malmö, Malmö
Department of Clinical Sciences, Lund University, Lund

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Peter Åsman Department of Endocrinology and Ophthalmology, Skåne University Hospital Malmö, Malmö
Department of Clinical Sciences, Lund University, Lund

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, plasma concentrations of TSH <0.2 mIU/l, and increased plasma levels of free T 4 and/or free T 3 . The patients were classified as having GD on the basis of clinical signs, the presence of TSH receptor antibodies (TRAb) and/or a diffuse uptake on thyroid

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Roberto Attanasio Endocrine Unit, IRCCS Istituto Galeazzi, Milan, Italy

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Enrico Papini Department of Endocrinology and Metabolism, Ospedale Regina Apostolorum, Rome, Italy

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Kristian H. Winther Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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evident in severe Se and iodine-deficient areas [ 13 ], but may also be detectable in marginal Se deficiency countries [ 14 ], as is the case in most of Europe. In patients with autoimmune thyroid disease, including GD, plasma Se and GPx concentrations

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Rosa M. García-Moreno Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain

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Cristina Escabias Nuclear Medicine Department, Hospital Universitario La Paz, Madrid, Spain

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Cristina Utrilla Radiology Department, Hospital Universitario La Paz, Madrid, Spain

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Elena Ruiz-Bravo Pathology Department, Hospital Universitario La Paz, Madrid, Spain

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Margarita Sánchez Ophthalmology Department, Hospital Universitario La Paz, Madrid, Spain

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Beatriz Lecumberri Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain

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]. Due to the capacity of metastatic thyroid cells to take up iodine from blood, distant metastases from PTC, which are relatively uncommon, can sometimes be detected during a post-therapy whole-body iodine scan (WBI) performed after treatment with

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Nora Dehina Institute for Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Berlin
Department of Ophthalmology, University Hospital Essen, Essen, Germany

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Peter Josef Hofmann Institute for Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Berlin

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Thomas Behrends Institute for Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Berlin

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Anja Eckstein Department of Ophthalmology, University Hospital Essen, Essen, Germany

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Lutz Schomburg Institute for Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Berlin

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significant inverse correlation between serum Se and TRAK concentrations (fig. 3 b; R 2 = 0.061; p = 0.024). In comparison, IGF1R-aAB were present in about 10% of serum samples. IGF1R-aAB levels were neither related to serum SePP (fig. 3 c) nor to serum Se

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Pepijn van Houten Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands

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James Nagarajah Roentgeninstitut Duesseldorf, Duesseldorf, Germany
Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands

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Janneke E W Walraven Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands

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Martin Jaeger Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands

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Adriana C H van Engen-van Grunsven Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands

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Johannes W Smit Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands

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Romana T Netea-Maier Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

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Introduction The large majority of patients with non-medullary thyroid carcinoma (NMTC) have an excellent prognosis and achieve remission after conventional treatment by surgery, radioactive iodine (RAI) treatment, and levothyroxine

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C. Daumerie Departments of Endocrinology, Université catholique de Louvain, University Hospital St-Luc, Brussels, Belgium

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A. Boschi Departments of Ophthalmology, Université catholique de Louvain, University Hospital St-Luc, Brussels, Belgium

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P. Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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/l), progressive eye-lid and conjunctival swelling of the left eye (CAS > 3) with proptosis and motility restriction appeared. The TSHR-Ab concentration remained elevated at 5.7 U/l (Medipan, with cutoff <2.5 U/l), but comparable to levels before the administration

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Nadine Johnson Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Vikash Chatrani Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Anna-Kay Taylor-Christmas Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Eric Choo-Kang Departments of Chemical Pathology, University of the West Indies, Kingston, Jamaica

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Monica Smikle Departments of Microbiology, University of the West Indies, Kingston, Jamaica

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Rosemarie Wright-Pascoe Departments of Medicine, University of the West Indies, Kingston, Jamaica

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Karen Phillips Departments of Medicine, University of the West Indies, Kingston, Jamaica

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Marvin Reid Tropical Metabolism Research Institute, University of the West Indies, Kingston, Jamaica

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urinary iodine excretion on random urinary samples of 30 subjects using the ion-selective electrode method on a Thermo-Orion Model 720A Instrument [ 23 ]. The inter- and intra-assay CVs were <10%. During pregnancy, median urinary iodine concentrations of

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