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Samer El-Kaissi Department of Endocrinology, Medical Subspecialties Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

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Laila AbdelWareth Department of Laboratory Medicine, National Reference Laboratory and Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

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Ruba Dajani Department of Pharmacy, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

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Terrence J. Lee-St. John Research Department, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

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Sherry Ann Santarina Research Department, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

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Fiona Makia Research Department, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

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Malak AlTakruri Department of Pharmacy, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

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AbedElRahman Kaskas Department of Patient Education, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

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Yahya Ahmed Department of Pharmacy, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

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plasma TSH (mIU/L) pre- and post-Ramadan modeled using mixed-effects regression for baseline TSH at 25th, 50th, and 75th percentiles. Reference range for plasma TSH 0.27–4.20 mIU/L. TSH increased in all 3 groups for patients at the 25th percentile

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Omar Abdul Hameed Ali Department of Surgery, University Charity and Teaching Hospital and Khartoum Breast Care Center

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Abdul Fatah Abdul Gadir Department of Pathology, University of Medical Sciences and Technology, Khartoum, Sudan

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, the long-term influence of a different iodine intake results in considerable differences in thyroid volume as early as in childhood. By adolescence, the volume approaches what might be defined as normal thyroid. In Sudan the reference range of thyroid

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Toshihide Yamamoto Yao Tokushukai General Hospital, Yao, Japan

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were measured 3 months after dosage adjustment. Doses to keep serum TSH levels within the reference range were maintained. All of them had stayed in a euthyroid state and had never been treated with medication containing glucocorticoids (GC). Seven

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Luba Freja Michaelsson Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

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Bjarke Borregaard Medici Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

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Jeppe Lerche la Cour Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Christian Selmer Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

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Michael Røder Department of Medicine, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
Division of Pharmacies and Reimbursement, Danish Health and Medicines Authority, Copenhagen, Denmark

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Hans Perrild Department of Endocrinology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark

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Nils Knudsen Department of Endocrinology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark

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Jens Faber Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Birte Nygaard Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

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, 14% of respondents reported that their TSH level was less than 0.01 mU/l (totally suppressed). The TSH level at the time of diagnosis of hypothyroidism was reported being below 4 mU/l in 26%, i.e. below the recommended upper normal reference range in

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Annamaria Erdei Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Annamaria Gazdag Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Bernadett Ujhelyi Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Edit B Nagy Division of Radiology and Imaging Science, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Ervin Berenyi Division of Radiology and Imaging Science, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Eszter Berta Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Zita Steiber Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Sandor Barna Division of Nuclear Medicine, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Emese Mezosi First Department of Internal Medicine, University of Pecs Medical School, Pecs, Hungary

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Miklos Bodor Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Endre V Nagy Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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exophthalmos and symmetric periorbital edema were seen. Low thyroid-stimulating hormone (TSH) (0.006 mU/L, reference range: 0.3-4.2 mU/L) was accompanied by normal free thyroxine and free triiodothyronine levels and elevated TSH receptor antibodies (TRAb: 10

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Maja Hjelm Lundgaard Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Allan Carlé Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark

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Ulla Birgitte Christiansen Department of Gynaecology and Obstetrics, Aalborg University Hospital, Aalborg, Denmark

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Anne Sørensen Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Gynaecology and Obstetrics, Aalborg University Hospital, Aalborg, Denmark

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Søren Risom Kristensen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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diagnosis of hypothyroidism was made, treatment with levothyroxine (50 µg per day) was unaltered. Biochemical assessment revealed improvement in patient thyroid function and TSH as well as T4 and T3 were within the reference ranges at 6 months follow

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J Karmisholt Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark

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S L Andersen Department of Clinical Institute, Aalborg University, Aalborg, Denmark
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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I Bulow-Pedersen Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark

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A Krejbjerg Department of Oncology, Aalborg University Hospital, Aalborg, Denmark

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B Nygaard Department of Endocrinology and Internal Medicine, Herlev University Hospital, Copenhagen, Denmark

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A Carlé Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark

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, agranulocytosis, and liver failure. Thyroid hormone and antibody assays Serum total T3 (reference range: Aalborg 1.1–2.5 nmol/L, Copenhagen 1.0–2.6 nmol/L), and TSH (reference range: Aalborg 0.30–4.5mU/L, Copenhagen 0.40–4.0 mU/L) were measured by automatic

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Marta Amaro da Silveira Duval Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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André Borsatto Zanella Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana Patrícia Cristo Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Carlo Sasso Faccin Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Marcia Silva Graudenz Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana Luiza Maia Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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consent. Laboratory Measurements TSH levels were measured by electrochemiluminescence immunoassay (ADVIA Centaur XP; Siemens, Tarrytown, NY, USA), with a reference range of 0.4–4.2 mIU/L. sTg and FNA-Tg were measured by chemiluminescence (ECLIA

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Cengiz Kara Department of Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey
Department of Pediatric Endocrinology, Faculty of Medicine, Istinye University, Istanbul, Turkey

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Jamala Mammadova Pediatric Endocrinology Unit, Altinbas University Medicalpark Bahçelievler Hospital, Istanbul, Turkey

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Ümmet Abur Department of Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey
Department of Medical Genetics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

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Cagri Gumuskaptan Department of Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey
Department of Medical Genetics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

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Elif İzci Güllü Department of Pediatric Endocrinology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

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Ayhan Dağdemir Department of Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey

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Murat Aydın Department of Pediatric Endocrinology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

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and free thyroxine (FT4) measurements, according to laboratory reference values (see supplementary material for reference ranges). All CH patients with low serum FT4 and/or persistently high (>10 µU/mL) TSH were treated with l -thyroxine (LT4). Two

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Chae Won Chung Department of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea
Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea

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Kyungsik Kim Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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Sue K Park Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Seoul, Korea

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Dal Lae Ju Department of Food Service and Nutrition Care, Seoul National University Hospital, Seoul, Korea

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Young Joo Park Department of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea

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Choong Ho Shin Department of Pediatrics, Seoul National University Children’s Hospital and Seoul National University College of Medicine, Seoul, Korea

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Jong Kwan Jun Department of Obstetrics and Gynecology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea

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June-Key Chung Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea

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Yoon Ju Song Department of Food Science and Nutrition, The Catholic University of Korea, Bucheon, Korea

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Young Ah Lee Department of Pediatrics, Seoul National University Children’s Hospital and Seoul National University College of Medicine, Seoul, Korea

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Gi Jeong Cheon Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea

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Sun Wook Cho Department of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea

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, Korea; free T3 and anti-TPO Ab, BRAHMS, Germany). The reference range, detection limit, intra-assay, and inter-assay CV were as follows: TSH (reference range: 0.30–5.00 mIU/L; detection limit: 0.02 mIU/L; intra-assay CV (%): 5.60/4.84/6.12; inter

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