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Caiyan Mo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Han Chen Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Qi Zhang Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Ying Guo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Liyong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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/L, free tri-iodothyronine (FT3) 3.28–6.47 pmol/L, total thyroxine (TT4) 69.97–152.52 nmol/L, total tri-iodothyronine (TT3) 1.01–2.48 nmol/L, TSH 0.49–4.91 μIU/mL, thyroglobulin antibody (Tg-Ab) 0–4 IU/mL, thyroid peroxidase antibody (TPO-Ab) 0–9 IU

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Laura Croce Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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Fausta Beneventi Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Federica Ripepi Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy

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Irene De Maggio Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Alberto Malovini Istituti Clinici Scientifici Maugeri IRCCS, Laboratory of Informatics and Systems Engineering for Clinical Research, Pavia (PV), Italy

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Camilla Bellingeri Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Francesca Coperchini Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy

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Marsida Teliti Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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Mario Rotondi Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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Arsenio Spinillo Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), Italy

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Flavia Magri Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy

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& Xu Z . Subclinical hypothyroidism with negative for thyroid peroxidase antibodies in pregnancy: intellectual development of offspring . Thyroid 2022 32 449 – 458 . ( https://doi.org/10.1089/thy.2021.0374 ) 5 Magri F Bellingeri C De Maggio

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Allan Carlé Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark

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Nils Knudsen Department of Endocrinology I, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark

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Torben Jørgensen Centre for Clinical Research and Prevention, Capital Region of Denmark, Copenhagen, Denmark
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Bettina Thuesen Centre for Clinical Research and Prevention, Capital Region of Denmark, Copenhagen, Denmark

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Jesper Karmisholt Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark

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Stine Linding Andersen Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Inge Bülow Pedersen Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark

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Characteristics Thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), and TRAb were measured after study end [ 20 , 23 ]. Subjects with antibody concentration above the functional sensitivity given by the manufacturer (TPOAb: > 30 kU/L, TgAb: > 20

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Berna Evranos Ogmen Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey

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Cevdet Aydin Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey

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Ibrahim Kilinc Department of General Surgery, Ankara Bilkent City Hospital, Ankara, Turkey

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Aysegul Aksoy Altinboga Department of Pathology, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey

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Reyhan Ersoy Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey

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Bekir Cakir Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey

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present series. Demographic characteristics and thyroid autoantibody status were recorded. Thyroid peroxidase antibody (anti-TPO) and thyroglobulin antibody (anti-Tg), were measured with a chemiluminescent immunoassay method (CMIA) (Architect i2000

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Kristian Hillert Winther Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Enrico Papini Department of Endocrinology and Metabolism, Ospedale Regina Apostolorum, Rome, Italy

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Roberto Attanasio Endocrine Unit, IRCCS Galeazzi Institute, Milan, Italy

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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dysfunction in pregnant thyroid peroxidase antibody-positive women living in an area with mild to moderate iodine deficiency: is iodine supplementation safe? J Clin Endocrinol Metab . 2000 Sep ; 85 ( 9 ): 3191 – 8 . 10.1210/jcem.85.9.6799 10999807 0021-972X

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Tereza Planck Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
Department of Endocrinology, Skåne University Hospital, Malmö, Sweden

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Bushra Shahida Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden

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Johan Malm Department of Translational Medicine, Section for Clinical Chemistry, Lund University, Malmö, Sweden

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Jonas Manjer Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
Department of Surgery, Skåne University Hospital, Malmö, Sweden

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of the study, in 219 patients with GD with available data, the D vitamin levels were correlated with laboratory and clinical parameters at diagnosis, including (i) the levels of free thyroxine (fT 4 ), free triiodothyronine (fT 3 ), thyroid peroxidase

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Roberto Attanasio Endocrine Unit, Galeazzi Orthopedic Institute IRCCS, Milan, Italy

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Endre V. Nagy Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Enrico Papini Department of Endocrinology and Metabolism, Ospedale Regina Apostolorum, Rome, Italy

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Petros Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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. Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception . N Engl J Med . 2019 Apr ; 380 ( 14 ): 1316 – 25 . 10.1056/NEJMoa1812537 30907987 0028-4793 24 Collet

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Jacqueline Jonklaas Division of Endocrinology, Georgetown University, Washington, District of Columbia, USA

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Antonio C. Bianco Section of Adult and Pediatric Endocrinology and Metabolism, University of Chicago, Chicago, Illinois, USA

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Anne R. Cappola Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Francesco S. Celi Division of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University, Richmond, Virginia, USA

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Eric Fliers Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, Amsterdam, The Netherlands

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Heike Heuer Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany

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Elizabeth A. McAninch Division of Endocrinology, Rush University, Chicago, Illinois, USA

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Lars C. Moeller Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany

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Birte Nygaard Center for Endocrinology and Metabolism, Department of Internal Medicine, Herlev and Gentofte Hospitals, Herlev, Denmark

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Anna M. Sawka Division of Endocrinology, University Health Network and University of Toronto, Toronto, Ontario, Canada

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Torquil Watt Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Colin M. Dayan Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom

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need to be standardized to measure trough levels of serum T3 (see also discussion in Topics 5 and 6). One recent study suggested that elevated thyroid peroxidase antibodies might be associated with dissatisfaction with LT4 therapy [ 69 ]. In this

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Mario Rotondi Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors and Chair of Endocrinology, University of Pavia, Pavia

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Maria Grazia Castagna Departments of Medical, Surgical and Neurological Sciences, Siena

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Carlo Cappelli Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy

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Cristina Ciuoli Departments of Medical, Surgical and Neurological Sciences, Siena

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Francesca Coperchini Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors and Chair of Endocrinology, University of Pavia, Pavia

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Francesco Chiofalo Departments of Medical, Surgical and Neurological Sciences, Siena

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Fabio Maino Departments of Medical, Surgical and Neurological Sciences, Siena

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Paola Palmitesta Departments of Social, Political and Cognitive Sciences, University of Siena, Siena

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Luca Chiovato Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors and Chair of Endocrinology, University of Pavia, Pavia

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Furio Pacini Departments of Medical, Surgical and Neurological Sciences, Siena

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Diagnostic Products Corp., Los Angeles, Calif., USA). Measurement of thyroglobulin antibody (Tg Ab) and thyroid peroxidase antibody (TPO Ab) was performed with a solid-phase, enzyme-labeled, chemiluminiscent sequential immunometric assay (Immulite 2000

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Salman Razvi Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom
Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, United Kingdom

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Vicky Ryan Institute of Health and Society, Newcastle University, Newcastle, United Kingdom

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Lorna Ingoe Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, United Kingdom
Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom

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Simon H. Pearce Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom
Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom

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Scott Wilkes School of Medicine, University of Sunderland, Sunderland, United Kingdom

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TSH (reference range 0.4–4.0 mU/L), free T4 (reference range 9–5 pmol/L), free T3 (reference range 2.5–7.5 pmol/L), thyroid peroxidase antibodies (positive if >35 IU/mL) and CTx were measured by electrochemiluminescence immunoassay on the Roche

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