Jinrong Fu
Jinrong Fu
Department of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China
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Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China
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Zihao Fan
Zihao Fan
Department of Geriatrics, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
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Liang He
Liang He
Department of Thyroid Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China
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Qian Liu
Qian Liu
Department of Endocrinology and Metabolism, Jilin Cancer Hospital, Changchun, Jilin, China
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He Liu
He Liu
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China
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Yushu Li
Yushu Li
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China
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Haixia Guan
Haixia Guan
Department of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
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and Metabolism 2013 98 4446 – 4456 . ( https://doi.org/10.1210/jc.2013-2568 ) 16 Lou X Wang H Tu Y Tan W Jiang C Sun J & Bao Z . Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients
Ilaria Muller
Ilaria Muller
Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Italy
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Anita Daturi
Anita Daturi
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Matteo Varallo
Matteo Varallo
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Tiziana E Re
Tiziana E Re
Internal Medicine - High Intensity of Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
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Davide Dazzi
Davide Dazzi
Casa di Cura Val Parma SRL, Langhirano (Parmigiano: Langhiràn), Italy
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Sara Maioli
Sara Maioli
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Erica Crivicich
Erica Crivicich
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Francesco Di Marco
Francesco Di Marco
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Virgilio Longari
Virgilio Longari
Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
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Beatrice Dazzi
Beatrice Dazzi
Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
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Massimo Castellani
Massimo Castellani
Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
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Giovanna Mantovani
Giovanna Mantovani
Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Italy
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Maura Arosio
Maura Arosio
Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Italy
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Mario Salvi
Mario Salvi
Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
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forms of diseases, usually the elderly, did not survive or could not be continuously studied due to their persisting poor health conditions after hospital discharge. Both the prevalence and the size of the focal hypoechoic areas at US decreased with
Irene Campi
Irene Campi
Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
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Marco Dell’Acqua
Marco Dell’Acqua
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Elisa Stellaria Grassi
Elisa Stellaria Grassi
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Maria Cristina Vigone
Maria Cristina Vigone
Department of Paediatrics, IRCCS San Raffaele Hospital, Milan, Italy
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Luca Persani
Luca Persani
Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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infection . European Journal of Endocrinology 2021 184 699 – 709 . ( https://doi.org/10.1530/EJE-20-1391 ) 31 Bhakri HL Fisher R Khadri A & MacMahon DG . Longitudinal study of thyroid function in acutely ill elderly patients using a sensitive
Massimiliano Andrioli
Massimiliano Andrioli
Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano
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Chiara Carzaniga
Chiara Carzaniga
Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano
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Luca Persani
Luca Persani
Division of Endocrine and Metabolic Diseases, San Luca Hospital, Istituto Auxologico Italiano
Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy
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Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy
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Introduction Nodular thyroid disease is a common finding, especially in females and in the elderly population. Thyroid nodules are found in 5% of the general population with the use of palpation [ 1 ], but high-resolution ultrasonography (US
Antonio C. Bianco
Antonio C. Bianco
Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Fla., USA
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Sabina Casula
Sabina Casula
Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Fla., USA
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DIO1 gene has been identified [ 42 ] in association with an increase in free T 3 and a decrease in FT 4 and rT 3 with no effect on serum TSH levels. Similarly, carriers of the D 1b -G/T (rs12095080) allele in elderly individuals had higher serum T 3
Caiyan Mo
Caiyan Mo
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Han Chen
Han Chen
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Qi Zhang
Qi Zhang
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Ying Guo
Ying Guo
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Liyong Zhong
Liyong Zhong
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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contraindicated in the elderly and in patients at high cardiovascular risk. Among the previously reported cases of TSHoma combined with GD, six cases ( 11 , 12 , 13 , 14 , 15 , 22 ) underwent TRH stimulation tests and three of them ( 13 , 15 , 22 ) also
Eveline Bruinstroop
Eveline Bruinstroop
Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
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Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
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Anne H van der Spek
Anne H van der Spek
Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
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Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
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Anita Boelen
Anita Boelen
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands
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Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands
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serum T4 were observed. However, a DIO1 polymorphism (rs11206244) in the elderly population leading to reduced Dio1 activity showed that the increase of serum rT3 was also accompanied by lower T3 and higher fT4 concentrations ( 21 ). Conversely, two
Carla Colombo
Carla Colombo
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Daniele Ceruti
Daniele Ceruti
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Massimiliano Succi
Massimiliano Succi
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Simone De Leo
Simone De Leo
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Matteo Trevisan
Matteo Trevisan
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Claudia Moneta
Claudia Moneta
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Laura Fugazzola
Laura Fugazzola
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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levels reflect the adrenal secretory reserve ( 32 , 33 ). Our data could be biased by the fact that androgens decrease with age, and several of our patients are elderly. Consistently, the decreased levels of some androgens (DHEA-S and androstenedione
Furio Pacini
Furio Pacini
Section of Endocrinology, University of Siena, Siena, Italy
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Dagmar Fuhrer
Dagmar Fuhrer
Department of Endocrinology, Diabetes and Metabolism, West German Cancer Centre (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany
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Rossella Elisei
Rossella Elisei
Section of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Daria Handkiewicz-Junak
Daria Handkiewicz-Junak
Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
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Sophie Leboulleux
Sophie Leboulleux
Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France
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Markus Luster
Markus Luster
Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany
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Martin Schlumberger
Martin Schlumberger
Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France
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Johannes W Smit
Johannes W Smit
Radboud University Medical Center, Nijmegen, Netherlands
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mutation, RAI therapy can be decided based on post-operative Tg and neck ultrasound. Indeed, in this category of patients the benefit of RAI therapy is controversial ( 26 , 27 ). In addition, we should consider that elderly patients, those with an
Fabyan Esberard de Lima Beltrão
Fabyan Esberard de Lima Beltrão
Lauro Wanderley University Hospital, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
University Center of João Pessoa – UNIPE, João Pessoa, PB, Brazil
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University Center of João Pessoa – UNIPE, João Pessoa, PB, Brazil
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Daniele Carvalhal de Almeida Beltrão
Daniele Carvalhal de Almeida Beltrão
University Center of João Pessoa – UNIPE, João Pessoa, PB, Brazil
Post-Graduation Program in Cognitive Neuroscience and Behavior, Psychology Department of the Center of Human Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Post-Graduation Program in Cognitive Neuroscience and Behavior, Psychology Department of the Center of Human Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Giulia Carvalhal
Giulia Carvalhal
Center for Biological and Health Sciences, Federal University of Campina Grande, Campina Grande, Paraíba, Brazil
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Fabyanna Lethicia de Lima Beltrão
Fabyanna Lethicia de Lima Beltrão
Post-Graduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Brazil
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Jocyel de Brito Oliveira
Jocyel de Brito Oliveira
Bioregulation Department, Health and Science Institut, Federal University of Bahia, Salvador, Bahia, Brazil
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Hatilla dos Santos Silva
Hatilla dos Santos Silva
Bioregulation Department, Health and Science Institut, Federal University of Bahia, Salvador, Bahia, Brazil
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Helena Mariana Pitangueira Teixeira
Helena Mariana Pitangueira Teixeira
Bioregulation Department, Health and Science Institut, Federal University of Bahia, Salvador, Bahia, Brazil
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Juliana Lopes Rodrigues
Juliana Lopes Rodrigues
Laboratory of Immunopharmacology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Brazil
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Camila Alexandrina Viana de Figueiredo
Camila Alexandrina Viana de Figueiredo
Laboratory of Immunopharmacology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Brazil
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Ryan dos Santos Costa
Ryan dos Santos Costa
Laboratory of Immunopharmacology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Brazil
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Fabio Hecht
Fabio Hecht
The Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
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Giciane Carvalho Vieira
Giciane Carvalho Vieira
Post-Graduation Program in Cognitive Neuroscience and Behavior, Psychology Department of the Center of Human Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Maria da Conceição Rodrigues Gonçalves
Maria da Conceição Rodrigues Gonçalves
Lauro Wanderley University Hospital, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Antonio C. Bianco
Antonio C. Bianco
Section of Endocrinology and Metabolism, Division of the Biological Sciences, University of Chicago, Chicago, Illinois, USA
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Helton Estrela Ramos
Helton Estrela Ramos
Post-Graduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Brazil
Postgraduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, BA, Brazil
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Postgraduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, BA, Brazil
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elderly ( 34 ). This indicates that an excess of TH can have significant consequences to muscle mass. Nonetheless, a study by Netzer et al. ( 35 ) on 267 older adults with persistent subclinical hypothyroidism revealed that LT4 treatment did not
