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. Each binding site contains several largely hydrophobic pockets formed by a main chain and side chains of β-sheets which can each accommodate one iodine atom from TH. The innermost binding pocket also allows nucleophiles (e.g. Ser-OH) to form polar
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pathogenic mechanisms: type 1 (AIT1) is a form of iodine-induced hyperthyroidism in response to the high iodine load present in amiodarone, while type 2 (AIT2) is a drug-induced destructive thyroiditis. There are also mixed forms, in which both pathogenic
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Benign Nodule For a 25-year-old patient with a nodular goiter, benign FNA, and no compressive symptoms, 54.7% suggest iodized salt, 24.4% levothyroxine treatment aiming at a low-normal thyroid-stimulating hormone, and 18.6% advise avoidance of iodine
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a number of individual specific environmental variables, iodine intake and tobacco smoking being those most studied, accounts for the final phenotype most likely unique to any individual [ 2 , 3 ]. The disease has negative socioeconomic consequences
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preoperative cancer diagnosis. Our aims were (1) to report the risk of malignancy in cases referred for surgery either with benign FNA or without FNA and identify possible predictive risk factors of malignancy in a population with recent moderately low iodine
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requested by 92.1%, while 1/4 of the respondents would order a thyroid scan (technetium-99) and only a minority would use radioactive iodine uptake (RAIU; 131 I) (fig. 2 a). Fig. 2 Rates of functional and anatomic investigations requested in the
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Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada
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’ responses to diet-induced hypothyroidism (e.g. chow low in iodine and supplemented with propylthiouracil) were not examined. From our experience with Igsf1 knockout mice, this challenge may be needed to reveal robust impairments in TSH synthesis and
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operation; KI = inorganic iodine (38 mg iodine daily); another ATD = change to MMI from PTU. * The OP patient died suddenly at home from an unknown cause just a few days before the scheduled total thyroidectomy. The remaining 9 AG patients (36
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine and School of Medicine, Seoul, Republic of Korea
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Division of Endocrinology and Metabolism, Department Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea
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gland ( 1 , 2 ). Current treatment options for patients with Graves’ hyperthyroidism include antithyroid drugs (ATDs), radioactive iodine (RAI) therapy, and surgery ( 1 , 3 , 4 ). Although geographical difference exists, ATD is the preferred first
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total thyroidectomy and radioactive iodine ablation at the Thyroid Cancer Clinic of our Institute and to assess which of these most accurately predicted outcomes using clinical end points. The secondary objective was to compare the performance of the