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Wenxing Guo The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Long Tan The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Shuyao Dong The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Ya Jin The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Mei Zhu The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China

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Hongyan Wei The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China

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Yanting Chen The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Lili Fan The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Cong Du The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

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Wanqi Zhang The Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China
The Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China
Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China

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-specific Tvol increased with an increase in BSA in all population groups. Males had significantly greater Tvol over the entire range of quantiles than did females. Table 4. The reference values for Tvol based on bootstrapping in subjects without TNs by

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Torquil Watt Department of Endocrinology, Copenhagen University Hospital Rigshospitalet
Institute of Public Health, University of Copenhagen

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Jakob Bue Bjorner Institute of Public Health, University of Copenhagen
National Research Centre for the Working Environment, Copenhagen

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Mogens Groenvold Institute of Public Health, University of Copenhagen
Department of Palliative Medicine, Bispebjerg Hospital

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Steen Joop Bonnema Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Åse Krogh Rasmussen Department of Endocrinology, Copenhagen University Hospital Rigshospitalet

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Ulla Feldt-Rasmussen Department of Endocrinology, Copenhagen University Hospital Rigshospitalet

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patients with autoimmune hypothyroidism (defined as any degree of serum thyroid-stimulating hormone (TSH) above the reference range at two consecutive measurements, with or without associated thyroid hormone levels below the reference range, and TPOAb level

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Jan Debeij Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden

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Suzanne C. Cannegieter Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden

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Bregje van Zaane Departments of Internal Medicine, Slotervaart Hospital
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands

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Anton P. van Zanten Departments of Clinical Biochemistry, Slotervaart Hospital

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Frits R. Rosendaal Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden

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Victor E.A. Gerdes Departments of Internal Medicine, Slotervaart Hospital
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands

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Pieter H. Reitsma Departments of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden

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Olaf M. Dekkers Departments of Clinical Epidemiology, Leiden University Medical Centre, Leiden
Departments of Endocrinology and Metabolism, Leiden University Medical Centre, Leiden

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in serum and plasma (regression coefficients: β ≥0.92). The laboratories' reference range in plasma was 10-24 pmol/l for fT 4 and 0.32-4.32 mU/l for TSH. Statistical Analysis The fT 4 results were returned by the routine laboratory in round

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Simon P. Mooijaart Institute for Evidence-Based Medicine in Old Age/IEMO, Leiden, The Netherlands
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

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the guideline it is recommended that thyroid hormone supplementation ‘should generally be stopped' in the oldest old with a TSH above the normal range but ≤10 mU/l, but the clinical evidence for this statement is graded as level 3 [i.e. low quality

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Camilla Bøgelund Larsen Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Eva Rabing Brix Petersen Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Aabenraa, Denmark

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Martin Overgaard Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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. Further analyses included search for a mutation in the TSH-receptor-gene and the TSH-beta-gene, also with negative results [ 7 ]. Plasma TSH in both parents was within the reference range. Fig. 2. a Serial dilution analyses were made with two

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Elske T. Massolt Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Mahdi  Salih Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands

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Carolien M. Beukhof Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Boen L.R. Kam Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands

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J.W. Burger Division of Surgical Oncology, Department of Surgery, Erasmus MC, Rotterdam, The Netherlands

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W. Edward Visser Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Ewout J. Hoorn Department of Nephrology and Transplantation, Erasmus MC, Rotterdam, The Netherlands

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Robin P. Peeters Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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participants. Laboratory Measurements Serum free T4 (FT4; reference range 11.0–25.0 pmol/L), total T4 (reference range 58.0–128.0 nmol/L), and total T3 (reference range 1.4–2.5 nmol/L) concentrations were measured by chemoluminescence assays (Vitros ECI

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Omar Abdul Hameed Ali Department of Surgery, University Charity and Teaching Hospital and Khartoum Breast Care Center

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Abdul Fatah Abdul Gadir Department of Pathology, University of Medical Sciences and Technology, Khartoum, Sudan

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, the long-term influence of a different iodine intake results in considerable differences in thyroid volume as early as in childhood. By adolescence, the volume approaches what might be defined as normal thyroid. In Sudan the reference range of thyroid

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João Roque Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal

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Tiago Nunes Silva Endocrinology, Diabetes and Metabolism Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
NOVA Medical School | Faculdade de Ciências Médicas of Universidade NOVA de Lisboa, Lisbon, Portugal
Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Catarina Regala Endocrinology, Diabetes and Metabolism Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Ricardo Rodrigues Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Endocrinology, Diabetes and Metabolism Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
NOVA Medical School | Faculdade de Ciências Médicas of Universidade NOVA de Lisboa, Lisbon, Portugal
Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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disease-related deaths ( 1 ). While DTC diagnosis can be usually established by fine-needle aspiration cytology, PDTC usually requires histological examination ( 4 ). Survival rates range between 50–85, 34–50, and 0% at 5, 10, and 15 years after diagnosis

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Rajesh Rajput Department of Endocrinology and Medicine Unit V, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, India

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Vaibhav Pathak Department of Endocrinology and Medicine Unit V, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, India

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and T4, with an increase in TSH with the weekly dose, but the mean TSH in both of our study groups remained within the reference range at all times. Pharmacogenomic studies have suggested that the polymorphism in genes for deiodinase enzyme may be

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Roberto Negro Division of Endocrinology, ‘V. Fazzi’ Hospital, Lecce, Italy

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diagnosis ranged from 40.4 to 657.8 mIU/l, and the IQ of the offspring measured at an age between 2 and 11 years were all normal. Based on the study by Momotani et al. [ 5 ] , in conjunction with the known negative impact of untreated overt hypothyroidism on

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