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J L Reverter Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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L Ferrer-Estopiñan Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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F Vázquez Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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S Ballesta Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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S Batule Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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A Perez-Montes de Oca Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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C Puig-Jové Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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M Puig-Domingo Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain

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years at the time of diagnosis, having undergone total or nearly total thyroidectomy or lobectomy based on cytological data, nodule size and symptoms, having undergone preoperative US evaluation of thyroid nodules, and to have an available pathologic

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Andrea Frasoldati Division of Endocrinology, Arcispedale S. Maria Nuova, Reggio Emilia, Italy

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Roberto Negro Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy

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Enrico Papini Division of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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and how MIT was offered. Core Needle Biopsy CNB was used by 52.0% for thyroid nodules with repeated non diagnostic FNA cytology and by 53.7% when there was suspicion of anaplastic carcinoma, metastasis or lymphoma. In contrast, it was used by

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Emilio Fiore Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy

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Francesco Latrofa Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy

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Paolo Vitti Department of Experimental and Clinical Medicine, Endocrinology Unit 1, University Hospital of Pisa, Pisa, Italy

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, reporting a low incidence of thyroid carcinoma in patients with HT [ 42 , 43 , 44 ]. Boi et al. [ 45 ] found a significant association between HT and PTC in a cytological series and Jankovic et al. [ 46 ] reported a significant relationship between HT and

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Evangelos Karvounis Department of Endocrine Surgery Center of Excellence, Euroclinic Hospital, Athens, Greece

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Ioannis Kappas Department of Endocrine Surgery Center of Excellence, Euroclinic Hospital, Athens, Greece

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Anna Angelousi First Department of Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece

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Georgios-Marios Makris Department of Gynecology, Euroclinic Hospital, Athens, Greece

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Eva Kassi First Department of Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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study that followed up all patients for at least 10 years and showed a case that relapsed beyond the expected 5 years [ 32 ]. The diagnosis of thyroid MALT lymphoma can be challenging. Kaba et al. [ 47 ] introduced specific cytological criteria

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Tamas Solymosi Endocrinology and Metabolism Clinic, Bugat Hospital, Gyöngyös, Hungary

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Andrea Frasoldati Endocrinology Unit of Arcispedale S. Maria Nuova, Reggio Emilia, Italy

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Laszlo Jambor Department of Radiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Gabor Laszlo Kovacs 1st Department of Medicine, Flohr Ferenc Hospital, Kerepestarcsa, Hungary

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Enrico Papini Regina Apostolorum Hospital in Albano, Rome, Italy

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Karoly Rucz 1st Department of Medicine, University of Pecs, Pecs, Hungary

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Gilles Russ Unité Thyroïde et Tumeurs Endocrines – Pr Leenhardt Hôpital La Pitie Salpetriere, Sorbonne Université, Paris, France

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Zsolt Karanyi Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Endre V. Nagy Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Introduction For more than three decades, the cornerstones in the clinical management of patients with thyroid nodules have been ultrasound (US) and fine-needle aspiration (FNA) cytology [ 1 - 5 ]. Robust evidence demonstrates that the risk of

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Simona Censi Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Elisabetta Cavedon Familial Tumor Unit, Veneto Institute of Oncology, (IOV)-IRCCS, Padua, Italy

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Sara Watutantrige-Fernando Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Susi Barollo Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Loris Bertazza Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Jacopo Manso Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Maurizio Iacobone Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Padua, Italy

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Davide Nacamulli Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Francesca Galuppini Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Gianmaria Pennelli Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Caterina Mian Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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), neuron-specific enolase, urinary 24-h metanephrine, and normetanephrine levels were all negative. The node was cytologically benign (TIR 2, SIAPEC-SIE 2014). Preoperative computed tomography of the abdomen and chest confirmed the large thyroid nodule

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Amruth R. Palla Division of Hematology and Oncology, Department of Internal Medicine, Ellis Fischel Cancer Center, University of Missouri Columbia, Columbia, Missouri, USA

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Craig Allen Bollig Department of Otolaryngology – Head and Neck Surgery, Ellis Fischel Cancer Center, University of Missouri Columbia, Columbia, Missouri, USA

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Jeffrey Brian Jorgensen Department of Otolaryngology – Head and Neck Surgery, Ellis Fischel Cancer Center, University of Missouri Columbia, Columbia, Missouri, USA

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visualized and appeared patent. A fine needle aspiration biopsy of the left neck mass was performed and the cytology was negative for malignant cells. Despite benign cytopathology and a relative lack of symptoms, a left thyroid lobectomy was offered to the

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Bengt Hallengren Departments of Endocrinology, Skåne University Hospital, Malmö
Department of Clinical Sciences, Lund University, Lund, Sweden

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Tereza Planck Departments of Endocrinology, Skåne University Hospital, Malmö
Department of Clinical Sciences, Lund University, Lund, Sweden

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Peter Åsman Departments of Ophthalmology, Skåne University Hospital, Malmö
Department of Clinical Sciences, Lund University, Lund, Sweden

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Mikael Lantz Departments of Endocrinology, Skåne University Hospital, Malmö
Department of Clinical Sciences, Lund University, Lund, Sweden

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grandmother had thyrotoxicosis, developed SAT in March 1998. The diagnosis was verified by fine-needle aspiration with cytological examination (fig. 1 ). She was given glucocorticoids and needed these for 1 year. In September 1998, her serum TSH level was

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Shigenobu Nagataki Nagasaki University, Ito Hospital, and Radiation Effects Association, Tokyo, Japan

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-needle aspiration cytology). Of these 116 patients, 102 underwent operations and the nodules were diagnosed as 100 papillary cancers, 1 poorly differentiated cancer, and 1 benign tumor. The second cycle of examinations began in April 2014 and included all of the

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Patrick W. Owens Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland

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Terri P. McVeigh Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland
Cancer Genetics Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom

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Eoin J. Fahey Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland

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Marcia Bell Department of Endocrinology, Galway University Hospital, Galway, Ireland

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Denis S. Quill Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland

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Michael J. Kerin Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland

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Aoife J. Lowery Discipline of Surgery, Lambe Institute for Translational Research, NUI Galway, Galway, Ireland

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thyroid cancer include diagnostic lobectomy for those with Thy3 or Thy4 fine-needle aspiration cytology (FNAC). Total thyroidectomy (TT) is advised for patients with Thy5 FNAC or with confirmed DTC following diagnostic lobectomy where tumour size exceeds 4

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