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Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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2023. The inclusion criteria were as follows: (1) age ≥ 18 years; (2) primary MTC (PMTC) before surgery or suspected recurrent or persistent disease after initial surgery, indicated by elevated calcitonin levels (> 15 pg/mL in PMTC and > 1 pg/mL in
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Department of Pediatrics, Turku University Hospital, Turku, Finland
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Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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been proposed as essential for maintaining inactivation of the TSHR ( 13 ). For the first time, we found that in the TSHR D633H KI mouse model NAH is not as stable as expected but rather is a dynamic condition involving age, sex, and Tshr allele
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effect. At a clinical level, the patient had a metastatic MTC diagnosed at 48 years of age. Somatic RET -mutated MTC is known to be more aggressive ( 2 , 12 ). This case illustrates the value of molecular tumor boards where multidisciplinary discussions
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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. Patient Age (years) Histotype TNM/AJCC stage ECOG status TKI treatment Adverse events (CTCAE v 5.0 grade) BMR ID M/F Diagnosis TKI start TKI Dose, mg Duration, months #1 F 36 39 FTC pT3bNXMX/I 1 LEN
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
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Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Stockholms Sjukhem Foundation's Research and Development Department, Stockholm, Sweden
Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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and the presence of any initial lymph node metastases that mainly guide the choice of radioiodine treatment activity ( 1 ). Several factors have been associated with lower iodine avidity of metastatic tissue, such as high patient age, large tumour
Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, South Korea
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Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, South Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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treatments. Approximately 10% of patients experience recurrence, which is frequently associated with distant metastasis ( 3 ). Factors related to the prognosis and recurrence of PTC include age, stage, lymph node metastasis, extrathyroid extension
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are presented as n (%). Characteristics Values Sex Female 15 (45) Male 18 (55) Mean age (years) at diagnosis 57 pTNM (OMS 2017) at diagnosis pT 1a 2 (6) 1b 4 (12
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( 21 ). Of the 66 patients with distant DTC metastases, 15 harbored a TERT mutation, and a rising Tg was observed in 14 patients. Notably, all these patients were classified as RAI-refractory and were associated with an older mean age (~58) at
Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany
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the Calgary and Southern Alberta Healthcare regions are prospectively assessed for their ATA recurrence risk, TNM (tumor-nodes-metastases)/MACIS (distant metastasis, patient age, completeness of resection, local invasion, and tumor size) staging, and
UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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Gustave Roussy, Villejuif, France
Sorbonne Université, Paris, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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’s carcinogenic effects, whether from accidental or therapeutic exposure. The likelihood of thyroid tumors is at its highest when exposure happens at a young age, and the risk increases proportionally with the radiation dose ( 1 ). Over 90% of these tumors are