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Giorgio Radetti
Giorgio Radetti
Marienklinik, Bolzano, Italy
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Franco Rigon
Franco Rigon
Department of Paediatrics, University of Padua, Padua, Italy
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Alessandro Salvatoni
Alessandro Salvatoni
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Irene Campi
Irene Campi
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, IRCCS, Milan, Italy
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Tiziana De Filippis
Tiziana De Filippis
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, IRCCS, Milan, Italy
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Valentina Cirello
Valentina Cirello
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, IRCCS, Milan, Italy
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Silvia Longhi
Silvia Longhi
Department of Paediatrics, Regional Hospital of Bolzano, Bolzano, Italy
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Fabiana Guizzardi
Fabiana Guizzardi
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, IRCCS, Milan, Italy
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Marco Bonomi
Marco Bonomi
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Luca Persani
Luca Persani
Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, IRCCS, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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adaptive mechanism, similarly to what was reported in some elderly euthyroid patients. In fact, some authors have reported that pituitary sensitivity to TH may increase with age and about 3% of elderly outpatients, display an inappropriately low fT4
Sander Barnhoorn
Sander Barnhoorn
Department of Molecular Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
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Marcel E Meima
Marcel E Meima
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
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Robin P Peeters
Robin P Peeters
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
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Veerle M Darras
Veerle M Darras
Laboratory of Comparative Endocrinology, Biology Department, KU Leuven, Leuven, Belgium
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Selmar Leeuwenburgh
Selmar Leeuwenburgh
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
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Jan H J Hoeijmakers
Jan H J Hoeijmakers
Department of Molecular Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Oncode Institute, Utrecht, The Netherlands
Institute for Genome Stability in Ageing and Disease, CECAD Research Centre, Cologne, Germany
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Oncode Institute, Utrecht, The Netherlands
Institute for Genome Stability in Ageing and Disease, CECAD Research Centre, Cologne, Germany
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Wilbert P Vermeij
Wilbert P Vermeij
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Oncode Institute, Utrecht, The Netherlands
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Oncode Institute, Utrecht, The Netherlands
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W Edward Visser
W Edward Visser
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
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changes during aging ( 2 , 3 , 4 , 5 ). In humans, thyroid-stimulating hormone (TSH) concentrations typically increase with age while concentrations of the bioactive T3 (triiodothyronine) decrease in the elderly population ( 3 , 5 ). Whether such
Eveline Bruinstroop
Eveline Bruinstroop
Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
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Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
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Anne H van der Spek
Anne H van der Spek
Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
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Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
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Anita Boelen
Anita Boelen
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands
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Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands
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serum T4 were observed. However, a DIO1 polymorphism (rs11206244) in the elderly population leading to reduced Dio1 activity showed that the increase of serum rT3 was also accompanied by lower T3 and higher fT4 concentrations ( 21 ). Conversely, two
