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Introduction Thyroid nodules are a very frequent problem in routine clinical practice ( 1 , 2 ). In regions with past or current iodine insufficiency, such as many European countries, the prevalence of autonomously functioning thyroid nodules
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with radioactive iodine (RAI) ablation given the wide and disseminated benign thyroid tissue displacements in surrounding tissues and the high risk of local recurrence. Although controversial in the West, RATS is the most frequent minimally invasive
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in case of clinical and US suspicion of thyrotoxicosis related to thyroiditis. 5) In current or previous iodine-deficient areas, the use of scintigraphy may be considered for nodular goiter and also for individuals with normal TSH. 6) See main text
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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University of Latvia, Faculty of Medicine, Riga, Latvia
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Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland
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(e.g. iodine sufficiency, genetic), but also by the classification systems themselves. This data may influence a clinical user's decision in favor of one TIRADS over the others. Furthermore, understanding this distribution can serve as a self
Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China
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a single hospital in southern China, which may limit its generalizability to other regions or populations. Third, the impact of iodine intake was not taken into account in the collection of dietary information. Fourth, laboratory tests for thyroid
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predisposition to thyroid cancer, or a history of radiation exposure to the head and neck in childhood ( 16 ); (iii) no previous history of thyroid surgery or radioactive iodine treatment; and (iv) underwent more than 1 year of follow-up. Based on our selection
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Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
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discriminating criterion in children may not be feasible due to age-related changing in thyroid volume ( 4 ). As for the clinical context, several risk factors for developing thyroid nodules and cancer in children have been identified: iodine deficiency
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Aixplorer machine used in the present study had different textures and were generally larger than the images used in the initial study ( 10 ). In addition, iodine status, environmental factors, and access to healthcare could affect the size and morphology of
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a previously iodine-deficient area still has a high rate of multinodular goiter ( 6 ). Our longitudinal data may offer useful guidance for follow-up, as not all nodules with low suspicion on US will be sufficiently characterized in the initial workup
Medical School, University of Milan, Milan, Italy
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Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
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Department of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
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Department of Diabetes, Endocrinology & Obesity Medicine, Salford Royal NHS Foundation & University Teaching Trust, Salford, UK
Medical School, European University of Cyprus, Nicosia, Cyprus
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John U Meng W . The prevalence of undiagnosed thyroid disorders in a previously iodine-deficient area . Thyroid 2003 13 803 – 810 . ( https://doi.org/10.1089/105072503768499680 ) 4 Furuya-Kanamori L Bell KJL Clark J Glasziou P Doi SAR