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Aglaia Kyrilli Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Nunzia Tacelli Department of Radiology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Lucia Russo Department of Medicine, DIMED, Internal Medicine 3, University of Padua, Via Giustiniani 2, 35128, Padova, Italy

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Laetitia Lebrun Department of Pathology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Isabelle Salmon Department of Pathology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Gilles Russ Thyroid and Endocrine Tumors, Institute of Endocrinology, Pitié Salpêtrière Hospital, Pierre et Marie Curie University, Paris, France

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Rodrigo Moreno-Reyes Department of Nuclear Medicine, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik, Brussels, Belgium

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Bernard Corvilain Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium

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Introduction Thyroid nodules are a very frequent problem in routine clinical practice ( 1 , 2 ). In regions with past or current iodine insufficiency, such as many European countries, the prevalence of autonomously functioning thyroid nodules

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Rémy Louvel Head and Neck Surgical Oncology Department, Institut Curie, PSL University, Paris, France

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Nathalie Badois Head and Neck Surgical Oncology Department, Institut Curie, PSL University, Paris, France

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Jerzy Klijanienko Pathology Department, Institut Curie, PSL University, Paris, France

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Ségolène Hescot Medical Oncology Department, Institut Curie, PSL University, Paris, France

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Caroline Hoffmann Head and Neck Surgical Oncology Department, Institut Curie, PSL University, Paris, France

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with radioactive iodine (RAI) ablation given the wide and disseminated benign thyroid tissue displacements in surrounding tissues and the high risk of local recurrence. Although controversial in the West, RATS is the most frequent minimally invasive

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Cosimo Durante Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Agnieszka Czarniecka M. Sklodowska-Curie National Research, Institute of Oncology Gliwice Branch, Gliwice, Poland

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Ralf Paschke Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Gilles Russ Thyroid and Endocrine Tumors Department, Pitié-Salpêtrière Hospital, Sorbonne University GRC N°16, Paris, France

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Fernando Schmitt Faculty of Medicine of University of Porto, CINTESIS@RISE and Institute of Molecular Pathology and Immunology, University of Porto (Ipatimup), Porto, Portugal

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Paula Soares Institute of Investigation and Innovation in Health (I3S), Faculty of Medicine of the University of Porto, Porto, Portugal

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Tamas Solymosi Endocrinology and Metabolism Clinic, Bugat Hospital, Gyöngyös, Hungary

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Enrico Papini Department of Endocrine and Metabolic Diseases, Regina Apostolorum Hospital, Albano, Rome, Italy

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in case of clinical and US suspicion of thyrotoxicosis related to thyroiditis. 5) In current or previous iodine-deficient areas, the use of scintigraphy may be considered for nodular goiter and also for individuals with normal TSH. 6) See main text

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Tommaso Piticchio Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland

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Gilles Russ Department of Thyroid and Endocrine Tumor Diseases, La Pitie-Salpetriere Hospital, 83 Bd de l’Hopital, Paris, France

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Maija Radzina Riga Stradins University, Radiology Research Laboratory, Riga, Latvia
University of Latvia, Faculty of Medicine, Riga, Latvia

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Francesco Frasca Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy

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Cosimo Durante Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Pierpaolo Trimboli Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland

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(e.g. iodine sufficiency, genetic), but also by the classification systems themselves. This data may influence a clinical user's decision in favor of one TIRADS over the others. Furthermore, understanding this distribution can serve as a self

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Ziyu Wan Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

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Ying Li Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Xiaoqian Dong Xiangya School of Nursing, Central South University, Changsha, Hunan, China

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Yue Kang Xiangya School of Nursing, Central South University, Changsha, Hunan, China

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Juan Luo Xiangya School of Nursing, Central South University, Changsha, Hunan, China

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Jiangang Wang Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Pingting Yang Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Yaqin Wang Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Yinglong Duan Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

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Jianfei Xie Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

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Andy S K Cheng Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong, China

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a single hospital in southern China, which may limit its generalizability to other regions or populations. Third, the impact of iodine intake was not taken into account in the collection of dietary information. Fourth, laboratory tests for thyroid

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Rui Guo Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Bowen Zheng Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Tao Wu Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Yufan Lian Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Tinghui Yin Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Yuting He Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Jingya Qin Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Zhicheng Yao Department of General Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Wen Xu Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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Jie Ren Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China

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predisposition to thyroid cancer, or a history of radiation exposure to the head and neck in childhood ( 16 ); (iii) no previous history of thyroid surgery or radioactive iodine treatment; and (iv) underwent more than 1 year of follow-up. Based on our selection

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Alessia Cozzolino Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Tiziana Filardi Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Ilaria Simonelli Service of Medical Statistics and Information Technology, Fatebenefratelli Foundation for Health Research and Education, Rome, Italy
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Giorgio Grani Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Camilla Virili Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy

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Ilaria Stramazzo Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy

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Maria Giulia Santaguida Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy

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Pietro Locantore Endocrinology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy

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Massimo Maurici Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Daniele Gianfrilli Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Andrea M Isidori Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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Cosimo Durante Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

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Carlotta Pozza Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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on behalf of TALENT Group
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discriminating criterion in children may not be feasible due to age-related changing in thyroid volume ( 4 ). As for the clinical context, several risk factors for developing thyroid nodules and cancer in children have been identified: iodine deficiency

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Kristine Z Swan Department of ORL, Head- and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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Johnson Thomas Department of Endocrinology, Mercy Hospital, Springfield, Missouri, USA

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Viveque E Nielsen Department of ORL, Head- and Neck Surgery, Odense University Hospital, Odense, Denmark

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Marie Louise Jespersen Department of Pathology, Aarhus University Hospital, Aarhus, Denmark

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Steen J Bonnema Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Aixplorer machine used in the present study had different textures and were generally larger than the images used in the initial study ( 10 ). In addition, iodine status, environmental factors, and access to healthcare could affect the size and morphology of

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M Grussendorf Department of Internal Medicine, University Hospital, Düsseldorf, Germany

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I Ruschenburg MVZ Wagnerstibbe Center for Cytology and Pathology, Einbeck, Germany

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G Brabant Department of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, UK

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a previously iodine-deficient area still has a high rate of multinodular goiter ( 6 ). Our longitudinal data may offer useful guidance for follow-up, as not all nodules with low suspicion on US will be sufficiently characterized in the initial workup

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Stamatina Ioakim CEDM, Centre of Endocrinology, Diabetes & Metabolism, Limassol, Cyprus
Medical School, University of Milan, Milan, Italy

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Akheel A Syed Department of Diabetes, Endocrinology & Obesity Medicine, Salford Royal NHS Foundation & University Teaching Trust, Salford, UK
Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

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George Zavros CEDM, Centre of Endocrinology, Diabetes & Metabolism, Limassol, Cyprus

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Michalis Picolos Alithias Endocrinology Centre, Nicosia, Cyprus

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Luca Persani Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
Department of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Angelos Kyriacou CEDM, Centre of Endocrinology, Diabetes & Metabolism, Limassol, Cyprus
Department of Diabetes, Endocrinology & Obesity Medicine, Salford Royal NHS Foundation & University Teaching Trust, Salford, UK
Medical School, European University of Cyprus, Nicosia, Cyprus

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John U Meng W . The prevalence of undiagnosed thyroid disorders in a previously iodine-deficient area . Thyroid 2003 13 803 – 810 . ( https://doi.org/10.1089/105072503768499680 ) 4 Furuya-Kanamori L Bell KJL Clark J Glasziou P Doi SAR

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