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Yiyun Cui
Yiyun Cui
Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China
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Jinlong Chen
Jinlong Chen
Department of Cardiology, Children's Hospital of Nanjing Medical University, Nanjing, China
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Rui Guo
Rui Guo
Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China
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Ruize Yang
Ruize Yang
Department of Public Health, Children's Hospital of Nanjing Medical University, Nanjing, China
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Dandan Chen
Dandan Chen
Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China
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Wei Gu
Wei Gu
Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China
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Francis Manyori Bigambo
Francis Manyori Bigambo
School of Public Health, Nanjing Medical University, Nanjing, China
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Xu Wang
Xu Wang
Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China
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remission and relapse groups on admission. Reference ranges Remission group ( n = 39) Relapse group ( n = 40) P ALT (U/L) 5–40 25.00 (19.00–37.00) 28.50 (21.75–37.50) 0.50 AST (U/L) 5–40 25.00 (20
Claire L Wood
Claire L Wood
Department of Paediatric Endocrinology, Great North Children’s Hospital, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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Niamh Morrison
Niamh Morrison
Department of Paediatric Endocrinology, Great North Children’s Hospital, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
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Michael Cole
Michael Cole
Population Health Sciences Institute, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne, UK
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Malcolm Donaldson
Malcolm Donaldson
Department of Child Health, University of Glasgow School of Medicine, Glasgow, UK
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David B Dunger
David B Dunger
Department of Paediatrics, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK
Wellcome Trust-MRC Institute of Metabolic Sciences, University of Cambridge, Cambridge, UK
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Wellcome Trust-MRC Institute of Metabolic Sciences, University of Cambridge, Cambridge, UK
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Ruth Wood
Ruth Wood
Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK
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Simon H S Pearce
Simon H S Pearce
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
Department of Endocrinology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
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Department of Endocrinology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
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Timothy D Cheetham
on behalf of the British Society for Paediatric Endocrinology and Diabetes (BSPED)
Timothy D Cheetham
Department of Paediatric Endocrinology, Great North Children’s Hospital, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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thyroxine (FT4) response in the two groups; specifically the time taken for TSH levels to rise or for FT4 concentrations to fall within the local reference ranges. Free tri-iodothyroinine (FT3) concentrations were not measured routinely in this trial
Mats Holmberg
Mats Holmberg
ANOVA, Karolinska University Hospital, Norra Stationsgatan 69, Stockholm, Sweden
Institute of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
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Institute of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
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Helge Malmgren
Helge Malmgren
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
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Peter F Berglund
Peter F Berglund
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
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Birgitta Johansson
Birgitta Johansson
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
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Helena Filipsson Nyström
Helena Filipsson Nyström
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden
Gothenburg Centre for Person Centred-Care (GPCC), Göteborg, Sweden
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Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden
Gothenburg Centre for Person Centred-Care (GPCC), Göteborg, Sweden
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Hospital, Göteborg ( n = 64) and from the Department of Medicine at Kungälv’s Hospital, Kungälv ( n = 1) in Sweden. They were eligible for the study if they were premenopausal, with fT4 levels ≥50 pmol/L (reference range: 12–22) and/or total T3 ≥6.0 nmol
Alessandro Brancatella
Alessandro Brancatella
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Laura Pierotti
Laura Pierotti
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Nicola Viola
Nicola Viola
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Isabella Lupi
Isabella Lupi
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Lucia Montanelli
Lucia Montanelli
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Chiara Cremolini
Chiara Cremolini
Oncology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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Paolo Piaggi
Paolo Piaggi
Department of Information Engineering, University of Pisa, Pisa, Italy
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Antonio Chella
Antonio Chella
Pneumology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
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Andrea Antonuzzo
Andrea Antonuzzo
Oncology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
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Daniele Sgrò
Daniele Sgrò
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Lucia Antonangeli
Lucia Antonangeli
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Chiara Sardella
Chiara Sardella
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Sandra Brogioni
Sandra Brogioni
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Claudio Marcocci
Claudio Marcocci
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Ferruccio Santini
Ferruccio Santini
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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Francesco Latrofa
Francesco Latrofa
Endocrinology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy
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). Reference ranges were 8–18 ng/dL for FT4, 2.5–5.0 ng/L for FT3 and 0.4–4 mIU/L for TSH. Tg was measured by an immunometric assay (Access Thyroglobulin assay; Beckman Coulter, Inc., Fullerton, CA, USA) (functional sensitivity 0.1 ng/mL). TgAbs were measured
J Karmisholt
J Karmisholt
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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S L Andersen
S L Andersen
Department of Clinical Institute, Aalborg University, Aalborg, Denmark
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
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Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
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I Bulow-Pedersen
I Bulow-Pedersen
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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A Krejbjerg
A Krejbjerg
Department of Oncology, Aalborg University Hospital, Aalborg, Denmark
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B Nygaard
B Nygaard
Department of Endocrinology and Internal Medicine, Herlev University Hospital, Copenhagen, Denmark
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A Carlé
A Carlé
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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, agranulocytosis, and liver failure. Thyroid hormone and antibody assays Serum total T3 (reference range: Aalborg 1.1–2.5 nmol/L, Copenhagen 1.0–2.6 nmol/L), and TSH (reference range: Aalborg 0.30–4.5mU/L, Copenhagen 0.40–4.0 mU/L) were measured by automatic
Birgitta Johansson
Birgitta Johansson
Department of Clinical Neuroscience, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Mats Holmberg
Mats Holmberg
ANOVA, Karolinska University Hospital, Norra Stationsgatan 69, Stockholm, Sweden
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
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Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
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Simon Skau
Simon Skau
Department of Clinical Neuroscience, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
Department of Pedagogical, Curricular and Professional Studies, Faculty of Education, University of Gothenburg, Gothenburg, Sweden
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Department of Pedagogical, Curricular and Professional Studies, Faculty of Education, University of Gothenburg, Gothenburg, Sweden
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Helge Malmgren
Helge Malmgren
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Helena Filipsson Nyström
Helena Filipsson Nyström
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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was 4.0 months. Inclusion criteria were as follows: (i) premenopausal, (ii) free thyroxine ≥ 50 pmol/L (reference range 12–22) and/or total triiodothyronine ≥ 6.0 pmol/L (reference range 1.3–3.1), and (iii) positive thyroid-stimulating hormone
Ringo Manta
Ringo Manta
Department of Nuclear Medicine, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Charlotte Martin
Charlotte Martin
Department of Infectious Diseases, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Vinciane Muls
Vinciane Muls
Department of Gastroenterology and Endoscopy, CHU Saint-Pierre, University Libre de Bruxelles (ULB), Brussels, Belgium
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Kris G Poppe
Kris G Poppe
Department of Endocrinology, CHU Saint Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Reference range Year 2020 Year 2021 March 23 April 7 April 9 June 22 August 5 December 7 February 2 March 18 a April 12 April 14 April 27 Thyrotropin (mIU/L) 0.27–4.20 5.42 7.36 2.86 1.35 3.21 2/29 1
Georgios Kostopoulos
Georgios Kostopoulos
Department of Endocrinology and Metabolism, Ippokratio General Hospital of Thessaloniki, Greece
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Grigoris Effraimidis
Grigoris Effraimidis
Department of Endocrinology and Metabolic Diseases, Larissa University Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
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subclinical hyperthyroidism and FT4 within the normal reference range. Study Year Country Design Subjects, n Age, years FU, years Thyroid function AF, % Risk (95% CI) Overt hyperthyroidism Selmer
Sébastien Verdickt
Sébastien Verdickt
Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium
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Falco Van Nes
Falco Van Nes
Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium
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Carolien Moyson
Carolien Moyson
Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium
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Toon Maes
Toon Maes
Department of Endocrinology, Imeldaziekenhuis Bonheiden, Bonheiden, Belgium
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Paul Van Crombrugge
Paul Van Crombrugge
Department of Endocrinology, OLV Ziekenhuis Aalst-Asse-Ninove, Aalst, Belgium
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Annick Van den Bruel
Annick Van den Bruel
Department of Endocrinology, AZ Sint Jan Brugge, Brugge, Belgium
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Brigitte Decallonne
Brigitte Decallonne
Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium
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euthyroidism defined as TSH and fT4 within the normal reference range in a patient not synchronously treated with ATDs or L-T4. Hyperthyroidism was defined as either not meeting the criteria of cure or having undergone thyroid surgery or having received a
Meihua Jin
Meihua Jin
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine and School of Medicine, Seoul, Republic of Korea
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Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine and School of Medicine, Seoul, Republic of Korea
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Ahreum Jang
Ahreum Jang
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Division of Endocrinology and Metabolism, Department Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea
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Division of Endocrinology and Metabolism, Department Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea
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Chae A Kim
Chae A Kim
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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Tae Yong Kim
Tae Yong Kim
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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Won Bae Kim
Won Bae Kim
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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Young Kee Shong
Young Kee Shong
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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Min Ji Jeon
Min Ji Jeon
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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Won Gu Kim
Won Gu Kim
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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measured by RIA using T3-CTK (DiaSorin SpA). The reference ranges of TSH, fT4, and total T3 were 0.4–4.5 mIU/L, 0.80–1.90 ng/dL, and 151–277 ng/dL, respectively. TRAb was measured using a competitive TSH-binding inhibitory immunoglobulin (TBII) assay by the
