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Introduction Advances in molecular genotyping with high-throughput sequencing have led to better understanding of the genetic landscape of thyroid cancer and ultimately to major improvements in the treatment of advanced thyroid cancers ( 1
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Department of Pediatrics, Turku University Hospital, Turku, Finland
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Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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Introduction Nonautoimmune hyperthyroidism (NAH) is caused by a constitutively activating thyroid stimulating hormone receptor (TSHR) germline mutation. Germline mutations in TSHR lead to sporadic and familial NAH (SNAH, FNAH) whereas somatic
Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany
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mutation-positive medullary thyroid cancer (MTC) or RET gene fusion-positive thyroid cancer. The early approval of these drugs was based on phase 1/2 data ( 1 , 2 , 3 , 4 , 5 ). Patients with thyroid cancer were one of the larger patient groups in the
Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, South Korea
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Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, South Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Introduction Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer, accounting for more than 90% of all thyroid cancers ( 1 ). PTC is generally an indolent tumor with a relatively favorable prognosis; indeed, the 10
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Graphical abstract Introduction Papillary thyroid carcinoma (PTC) typically has an excellent clinical prognosis. However, 10% of cases of differentiated thyroid cancers (DTC) will progress to a metastatic stage after receiving initial
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
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Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Stockholms Sjukhem Foundation's Research and Development Department, Stockholm, Sweden
Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Introduction Differentiated thyroid cancer is treated with surgery, and in cases of larger tumours or cervical lymph node metastases, additional hormone suppression and radioiodine therapy are given. Successful radioiodine therapy requires
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Introduction Tyrosine kinase inhibitors (TKIs) and target therapies are efficiently used in the treatment of progressive radioiodine-refractory differentiated thyroid cancer (RAI-R DTC) and advanced medullary thyroid cancer (MTC) ( 1 ). In
Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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Introduction Medullary thyroid cancer (MTC) accounts for about 2% of all thyroid cancers. About 20–25% of MTC cases are hereditary, caused by a mutation in the RET proto-oncogene. However, in most cases, MTC is sporadic with no underlying
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Medullary thyroid carcinoma (MTC) is a rare but aggressive thyroid tumor, with 25% of hereditary and 75% of sporadic forms. RET mutations are found in 98% of hereditary MTC and in 55% of sporadic MTC ( 1 ). The most frequent somatic RET
UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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Gustave Roussy, Villejuif, France
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Gustave Roussy, Villejuif, France
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Gustave Roussy, Villejuif, France
Sorbonne Université, Paris, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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Introduction Ionizing radiation (IR) leads to various delayed cellular effects, including chromosomal rearrangements, which are believed to play a key role in radiation-induced carcinogenesis. The thyroid gland is particularly sensitive to IR