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Luigino Dal Maso Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Daniela Pierannunzio National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy

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Silvia Francisci National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy

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Angela De Paoli Epidemiological Department, Azienda Zero, Padova, Italy

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Federica Toffolutti Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Salvatore Vaccarella Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France

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Silvia Franceschi Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Ugo Fedeli Epidemiological Department, Azienda Zero, Padova, Italy

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of the DEPTH Working Group
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Introduction Radioactive iodine (RAI) treatment may be used after total thyroidectomy (TT) for thyroid cancer for several purposes: remnant ablation to facilitate detection of recurrent disease, adjuvant treatment of subclinical residual tumor

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Lucie Allard Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Unité Thyroïde-Tumeurs Endocrines, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Jérôme Alexandre Denis Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Service de Biochimie Endocrinienne et Oncologique, UF Oncobiologie Cellulaire et Moléculaire, Pitié Salpêtrière, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Gaëlle Godiris Petit Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Service de Chirurgie Générale, Viscérale et Endocrinienne, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Gabrielle Deniziaut Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Service d’Anatomo-Pathologie, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Cécile Ghander Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Unité Thyroïde-Tumeurs Endocrines, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Elise Mathy Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Unité Thyroïde-Tumeurs Endocrines, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Erell Guillerm Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, UF d’Onco-Angiogénétique et Génomique des Tumeurs Solides, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Charlotte Lussey-Lepoutre Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Service de Médecine Nucléaire, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Laurence Leenhardt Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Unité Thyroïde-Tumeurs Endocrines, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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Camille Buffet Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Unité Thyroïde-Tumeurs Endocrines, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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successfully, total thyroidectomy and central and right lymph node dissection were performed. During surgery, the subhyoid muscles and right internal jugular vein had to be excised due to cancer invasion, but the tumor was easily removed from the pharyngeal

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Takaaki Konishi Department of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan

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Michimasa Fujiogi Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Nobuaki Michihata Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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Takayoshi Niwa Department of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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Kojiro Morita Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan
Department of Health Services, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

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Hiroki Matsui Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan

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Kiyohide Fushimi Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

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Masahiko Tanabe Department of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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Yasuyuki Seto Department of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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Hideo Yasunaga Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan

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Introduction Thyroidectomy is the only radical treatment for thyroid cancer. Several complications may occur following thyroidectomy: for example, post-operative bleeding, recurrent laryngeal nerve (RLN) paralysis, post-operative hypocalcaemia

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Ian D Hay Department of Medicine 1, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Suneetha Kaggal Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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Geoffrey B Thompson Department of Surgery, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA

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are convinced that at our institution, radioiodine remnant ablation (RRA), when administered after potentially curative bilateral thyroidectomy (BT) to low-risk (MACIS scores <6) adult PTC (APTC) patients, has not reduced ( 7 ) either cause

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Inês Damásio Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Joana Simões-Pereira Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Sara Donato Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Nova Medical School, Lisbon, Portugal

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Mariana Horta Radiology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon Portugal

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Branca Maria Cavaco Molecular Pathobiology Research Unit (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Miguel Rito Pathology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Pedro Gomes Head and Neck Surgery Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Nova Medical School, Lisbon, Portugal

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( Fig. 1D ). At this point, ATC was considered surgically resectable, and the patient underwent total thyroidectomy plus central lymphadenectomy. Histological analysis ( Fig. 2B and C ) revealed the presence of residual foci of ATC with tracheal

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Furio Pacini Section of Endocrinology, University of Siena, Siena, Italy

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Dagmar Fuhrer Department of Endocrinology, Diabetes and Metabolism, West German Cancer Centre (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Rossella Elisei Section of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Daria Handkiewicz-Junak Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland

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Sophie Leboulleux Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France

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Markus Luster Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany

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Martin Schlumberger Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France

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Johannes W Smit Radboud University Medical Center, Nijmegen, Netherlands

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which may be biased in many respects. Nowadays, whenever available we should rely on prospective studies which are feasible, as demonstrated by several trials ( 4 , 5 , 6 , 7 ). Definition of RAI therapy After total thyroidectomy, radioactive

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Diana Borges Duarte Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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Vânia Benido Silva Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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Guilherme Assunção Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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André Couto Carvalho Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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Cláudia Freitas Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal

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patient. Electronic Health Registry and Primary Care data were used to determine the causes of death. Papillary thyroid cancer treatment and follow-up All patients underwent surgical treatment (total thyroidectomy or totalization of previous sub

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Jiahui Wu Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Xunyang Hu Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Paula Seal EFW Radiology, Calgary, Alberta, Canada
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Parthiv Amin Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Brendan Diederichs Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Mayfair Radiology, Calgary, Alberta, Canada

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Ralf Paschke Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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-escalation guideline update in 2016. The ATA management guidelines for adult patients with thyroid nodules and thyroid cancer includes the use of total thyroidectomy (TTX), with or without RAI, and lobectomy for the treatment of thyroid cancers ( 1 ). However, the ATA

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Adile Begüm Bahçecioğlu Department of Endocrinology and Metabolism, Ankara University, School of Medicine, Ankara, Turkey

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Alptekin Gürsoy Department of Endocrinology and Metabolism, Ankara Guven Hospital, Ankara, Turkey

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Serpil Dizbay Sak Department of Pathology, Ankara University, School of Medicine Ankara, Turkey

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Seyfettin Ilgan Department of Nuclear Medicine, Ankara Guven Hospital, Ankara, Turkey

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Banu Bilezikçi Department of Pathology, Ankara Guven Hospital, Ankara, Turkey

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Murat Faik Erdoğan Department of Endocrinology and Metabolism, Ankara University, School of Medicine, Ankara, Turkey

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the patients were female. Mean age of patients was 38.3 ± 10.2. Surgical procedures were total thyroidectomy and central lymph node dissection (CLND) in 75 (66%), total thyroidectomy central and right LND in 13 (11%), lobectomy and ipsilateral CLND in

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Nianting Ju Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Liying Hou Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Hongjun Song Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zhongling Qiu Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yang Wang Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zhenkui Sun Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Quanyong Luo Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Chentian Shen Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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considered to be a significant treatment for eliminating the remnant thyroid tissue after thyroidectomy, which can increase the specificity of detectable serum thyroglobulin (Tg) as a tumor marker and potentially improve the quality of future 131 I whole

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