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  • Hyperthyroidism and thyrotoxicosis x
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Bruno Bouça Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Ana Cláudia Martins Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Paula Bogalho Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Lídia Sousa Cardiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Tiago Bilhim Interventional Radiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Filipe Veloso Gomes Interventional Radiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Élia Coimbra Interventional Radiology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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Ana Agapito Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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José Silva-Nunes Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal

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challenging scenario ( 2 ). The European Thyroid Association recommends emergency thyroidectomy for AIT unresponsive to medical therapy in patients with severe underlying cardiac disease or deteriorating cardiac function ( 6 ). Nevertheless, this decision

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Marta Nascimento Soares Faculty of Medicine of the University of Porto, Porto, Portugal

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Marta Borges-Canha Faculty of Medicine of the University of Porto, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Department of Surgery and Physiology, Cardiovascular Research Unit, Faculty of Medicine from the University of Porto, Porto, Portugal

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Celestino Neves Faculty of Medicine of the University of Porto, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Institute for Research Innovation in Health, University of Porto, Porto, Portugal

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João Sérgio Neves Faculty of Medicine of the University of Porto, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Department of Surgery and Physiology, Cardiovascular Research Unit, Faculty of Medicine from the University of Porto, Porto, Portugal

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Davide Carvalho Faculty of Medicine of the University of Porto, Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Institute for Research Innovation in Health, University of Porto, Porto, Portugal

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, smoking habits, treatment for Graves’ disease (type of antithyroid drug, maximum dose, duration and number of iodine ablative doses, and thyroidectomy), diagnosis of ophthalmopathy, diagnosis of dermopathy, thyroid ultrasound results, results of biopsies

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Caiyan Mo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Han Chen Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Qi Zhang Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Ying Guo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Liyong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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5.54 13 ATD, thyroidectomy, TSS N/A 12 Arai et al . ( 20 ) 2017 Japan 40/F GD complicated with TSHoma Headache and exophthalmos 0.27 13 ATD, TSS Recovery 13 Li et al . ( 21 ) 2018 China 55/M GD

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Meihua Jin Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine and School of Medicine, Seoul, Republic of Korea

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Ahreum Jang Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Division of Endocrinology and Metabolism, Department Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea

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Chae A Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Tae Yong Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Bae Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Young Kee Shong Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Min Ji Jeon Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Gu Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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the dynamic change of TRAb for the first time, which needed to be verified and highlighted. Patients with persistently elevated (smoldering) TRAb could continue long-term ATD maintenance or alternate to definite therapy with RAI or thyroidectomy ( 1

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Stefan Matei Constantinescu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Julien Hospel Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Chantal Daumerie Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Orsalia Alexopoulou Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Dominique Maiter Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Maria-Cristina Burlacu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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and/or suggestive imaging, or the necessity to perform total thyroidectomy after a first uninterrupted course of treatment. The diagnosis of GD was made on the basis of the association of low TSH, elevated free FT4 and/or elevated FT3, imaging

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Hippolyte Dupuis Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France

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Emilie Merlen Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France

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Arnaud Jannin Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France

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Philippe Jamme University of Lille, Lille, France
Department of Dermatology, Lille University Hospital, Lille, France

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Alexandre Fagart Department of Nuclear Medicine, Valenciennes Hospital Center, Valenciennes, France

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Marie-Christine Vantyghem Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France

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Miriam Ladsous Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France

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may be less sensitive to ICI than other benign nodules. The patient refused, so far, a new FNA and/or thyroidectomy. Although the biological monitoring of thyroid function before and during the use of ICI is now recommended by guidelines, US

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Agneta Lindo Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
The National Task Force in Hyperthyroidism, Swedish National System for Knowledge-Driven Management, Umeå, Sweden

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Anne Breikert The National Task Force in Hyperthyroidism, Swedish National System for Knowledge-Driven Management, Umeå, Sweden
Department of Endocrinology and Diabetes, Örebro University Hospital, Örebro, Sweden

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Peter Lakwijk The National Task Force in Hyperthyroidism, Swedish National System for Knowledge-Driven Management, Umeå, Sweden
Thyroid Federation International, Kungsbacka, Sweden

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Christin Lundberg The National Task Force in Hyperthyroidism, Swedish National System for Knowledge-Driven Management, Umeå, Sweden
Swedish Thyroid Association, Stockholm, Sweden

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Katarina Lunner The National Task Force in Hyperthyroidism, Swedish National System for Knowledge-Driven Management, Umeå, Sweden
Swedish Thyroid Association, Stockholm, Sweden

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Birgitta Johansson Institute of Neuroscience and Physiology Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

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Helena Filipsson Nyström Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
The National Task Force in Hyperthyroidism, Swedish National System for Knowledge-Driven Management, Umeå, Sweden
Sweden and Wallenberg Center for Molecular and Translational Medicine, Västra Götaland Region, Göteborg, Sweden

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thyroidectomy, GD patients expressed that they had wanted more information before the surgery, such as the healthcare staff explaining the disease in detail, and that they had received information about possible post-operative side effects such as weight gain

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Sébastien Verdickt Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium

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Falco Van Nes Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium

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Carolien Moyson Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium

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Toon Maes Department of Endocrinology, Imeldaziekenhuis Bonheiden, Bonheiden, Belgium

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Paul Van Crombrugge Department of Endocrinology, OLV Ziekenhuis Aalst-Asse-Ninove, Aalst, Belgium

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Annick Van den Bruel Department of Endocrinology, AZ Sint Jan Brugge, Brugge, Belgium

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Brigitte Decallonne Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium

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by the departments of nuclear medicine. The search was limited to patients who were administered RAI in the activity range from 148 to 555 MBq, as lower activities are only used for diagnostic purposes and higher activities for selective ablation post-thyroidectomy

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Mats Holmberg ANOVA, Karolinska University Hospital, Norra Stationsgatan 69, Stockholm, Sweden
Institute of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden

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Helge Malmgren Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

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Peter F Berglund Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

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Birgitta Johansson Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

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Helena Filipsson Nyström Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden
Gothenburg Centre for Person Centred-Care (GPCC), Göteborg, Sweden

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ATD, given according to clinical routine in block-and-replacement fashion or surgery following ATD pretreatment. After 15 months, 20/55 (36.4%) had undergone thyroidectomy, one (1.8%) patient was treated with radioactive iodine, 26/55 (47.3%) were on

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Birgitta Johansson Department of Clinical Neuroscience, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden

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Mats Holmberg ANOVA, Karolinska University Hospital, Norra Stationsgatan 69, Stockholm, Sweden
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden

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Simon Skau Department of Clinical Neuroscience, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
Department of Pedagogical, Curricular and Professional Studies, Faculty of Education, University of Gothenburg, Gothenburg, Sweden

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Helge Malmgren Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Helena Filipsson Nyström Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden

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were initially treated with ATD and when necessary with surgery. At 15 months, 36% had undergone thyroidectomy, one patient was treated with radioactive iodine, 47% were receiving ATD, and 17% had no treatment and were in remission. Due to the high

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