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Laboratorio 6, Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Delegación Tlalpan, Ciudad de México, México
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°C) and maintained with food and water ad libitum. After a week of conditioning, animals were randomly divided into two mothers groups ( n = 9): (i) euthyroid and (ii) hypothyroid. Hypothyroidism was induced surgically by a thyroidectomy with
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Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium
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Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium
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Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium
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substitution therapy. The aetiology of PHT was most often surgical (total thyroidectomy, n = 16) and autoimmune thyroid disease ( n = 14), shown in Table 2 (see Supplementary files). Table 2 ThyPRO questionnaire. CHT PHT
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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who had a total thyroidectomy due to thyroid cancer. By this, we excluded the often-used L-T3 pretreatment before radioiodine ablation or uptake measurement as the explanation. The explanation could be that this group of people are more often seen by
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Data and Data Support, Region Zealand, Sorø, Denmark
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Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
Department of Cardiology, University Hospital Nordsjælland, Hillerød, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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, Denmark, between August 2015 and February 2018. The participants had to be 20–75 years of age and had a TSH > 10.0 mIU/L at diagnosis as well as TPOAb positivity. Exclusion criteria were severe comorbidity, pregnancy, previous thyroidectomy, amiodarone
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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total thyroidectomy. In this study of 18 subjects, the normalization of TSH levels occurred only with supraphysiological levels of fT4 (>20 pmol/L) associated with symptoms of thyrotoxicosis (such as nervousness, tachycardia, diarrhea, or insomnia
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individuals could be targeted in a separate study. Other patient groups are those who are surgically athyreotic and those individuals with thyroid cancer who have received radioactive iodine therapy after thyroidectomy, who might theoretically have the lowest
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with a history of total thyroidectomy. At the second visit, 5 patients out of 39 (all of whom were receiving LT4 preparations other than T4® at the study entry) had serum TSH levels out of the target range, so adjustment of the dose was performed, and