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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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thyroxine (RETH) ( 18 ) in patients with different causes of hypothyroidism, including total thyroidectomy. Differently from RTHβ patients, RETH patients had a decreased T3/T4 ratio, suggesting that D2 functional deficiency underlies RETH but not RTHβ. In
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
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Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands
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Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, the Netherlands
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after thyroidectomy with approximately 30% of Dio1 compared to euthyroid rats. Conversely, increased liver Dio1 is found after T4 injection in rats ( 7 , 8 ). Therefore, Dio1 expression and activity are currently the best indicators of hepatic T3 status