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Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China
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inflammation in the development of AIT. To test this hypothesis, we examined the circadian characteristics in AIT and investigated the effects of light shift (LS) on thyroid inflammation. Materials and methods Recruitment of patients and sample
Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Padua University Hospital, Padua, Italy
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natural course a progressive (active) phase lasting 6–18 months where inflammation is florid and a subsequent quiescent (inactive) phase where fibrotic processes are prevalent ( 4 ). There are many grading systems for evaluating TED severity, such as the
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Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Introduction Thyroid eye disease (TED) is a specific autoimmune condition associated with inflammation of the thyroid, orbit, and periorbital tissues ( 1 , 2 ) that often endangers the patient’s vision and appearance ( 3 ). TED patients
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in inflammation, such as IL-1β, matrix metalloproteinase-3, and vascular endothelial growth factor, were also overexpressed. Furthermore, the expression of CYR61 was greater in the active phase than in the chronic phase of GO. A similar study was
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Endocrinology Division, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA
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item scores 1 point if present a Spontaneous retrobulbar pain Pain on attempted up or lateral gaze Redness of the eyelids Redness of the conjunctiva Swelling of the eyelids Inflammation of the caruncle and
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are characterized by lymphocytic infiltration of the thyroid gland, which, however, differently affects thyroid function. In the case of HT, the resulting inflammation leads to follicular cell damage, thyroid gland destruction, and development of
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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-inflammatory and immunomodulatory effects with chronic low-dose treatment in many autoimmune diseases. A study used MTX alone as second-line therapy in GO patients who failed to respond to MP and found that 29% achieved a VISA (vision loss, inflammation, strabismus
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. Intravenous glucocorticoids remain the treatment of choice for patients whose principal clinical feature is soft tissue inflammation. Teprotumumab may be considered in patients whose principal feature is soft tissue inflammation, and there are prevailing
INSERM 1086 ANTICIPE, Caen University, Caen, France
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previously shown in an aseptic inflammation model ( 12 ) and in the vessel walls of the abdominal aorta and aneurysms ( 13 , 14 ). Karantanis et al. suggested that fibrosis might also play a role in 18 FDG uptake ( 6 ). Our results also show that a high
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in almost all cases, except, perhaps, for the mildest cases within the spectrum of active, moderate-to-severe GO. In fact, it is rare that significant inflammation (activity) is not associated with some degree of diplopia and/or exophthalmos, and