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-specific reference range has not been established yet. Actually, for the determination of TSH pregnancy-specific reference range, the European Thyroid Association and American Thyroid Association (ATA) guidelines propose to exclude the following conditions: TAI
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
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Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
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evaluation of maternal thyroid function in early pregnancy is challenged by the physiological alterations in thyroid function and binding proteins associated with the pregnant state ( 7 ). Thus, pregnancy- and method-specific reference ranges are needed for
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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physiological changes in maternal thyroid function occur, and it is well-established that these changes necessitate pregnancy-specific reference ranges for thyroid function tests in pregnant women ( 3 ). The use of trimester-specific reference ranges is
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within the trimester-specific pregnancy reference range or, when not available, to the following reference range upper limits: first trimester, 2.5 mU/L; second trimester, 3.0 mU/L; third trimester, 3.5 mU/L ( 2 ). The more recent American Thyroid
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
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Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
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Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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/L at the lower or upper reference range ( 46 , 47 , 48 ). However, different fT4 IAs have varying techniques and reagent composition in measuring fT4 concentrations, meaning pregnancy does not influence all different IAs to the same extent as was
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain
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Department of Obstetrics & Gynecology, Germans Trias i Pujol University Hospital, Badalona, Spain
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Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain
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Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain
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Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
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Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain
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Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain
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women differs from non-pregnant women, and current guidelines recommend to establish local reference ranges for thyroid hormone values during specific time points of pregnancy ( 6 ). Our group has recently described trimester-specific reference ranges
Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea
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Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
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Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Seoul, Korea
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Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
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Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
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, Korea; free T3 and anti-TPO Ab, BRAHMS, Germany). The reference range, detection limit, intra-assay, and inter-assay CV were as follows: TSH (reference range: 0.30–5.00 mIU/L; detection limit: 0.02 mIU/L; intra-assay CV (%): 5.60/4.84/6.12; inter
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reference ranges of TSH and FT4 during pregnancy in TPO-Ab negative women excluding women on thyroid hormone medication, using the 2.5th and 97.5th percentile to define the lower and upper limit of normal thyroid function. IH was defined as an FT4
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institutional trimester-specific limits for serum TSH and FT4 ( 10 ). Our reference range for serum TSH (2.5–97.5th percentile) during the period 11 (9–14) weeks was 0.06–3.74 mIU/L, and 10.29–18.02 pmol/L for serum FT4 ( 10 ). Thyroid autoimmunity (TAI) was
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy
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Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy
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Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy
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Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy
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using a third generation immunoassay Immunolite 2000® Systems Analyzer (Siemens Healthcare) employing monoclonal antibodies. In the absence of a trimester-specific reference range, we chose the reference range for TSH in the non-pregnant adult population