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X Y Hu
X Y Hu
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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J Wu
J Wu
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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P Seal
P Seal
EFW Radiology, Calgary, Alberta, Canada
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S A Ghaznavi
S A Ghaznavi
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Department of Medicine, Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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C Symonds
C Symonds
Department of Medicine, Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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S Kinnear
S Kinnear
Department of Medicine, Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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R Paschke
R Paschke
Department of Medicine, Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Introduction Thyroid ultrasound (TUS) is the most sensitive and cost-effective modality for the evaluation of thyroid nodules ( 1 ). When thyroid nodules are incidentally discovered on other imaging modalities, current guidelines suggest that
Tamas Solymosi
Tamas Solymosi
Endocrinology and Metabolism Clinic, Bugat Hospital, Gyöngyös, Hungary
Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Laszlo Hegedűs
Laszlo Hegedűs
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Steen J Bonnema
Steen J Bonnema
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Andrea Frasoldati
Andrea Frasoldati
Endocrinology Unit of Arcispedale S Maria Nuova, Reggio Emilia, Italy
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Laszlo Jambor
Laszlo Jambor
Department of Radiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Zsolt Karanyi
Zsolt Karanyi
Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Gabor L Kovacs
Gabor L Kovacs
1st Department of Medicine, Flohr Ferenc Hospital, Kistarcsa, Hungary
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Enrico Papini
Enrico Papini
Regina Apostolorum Hospital in Albano, Rome, Italy
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Karoly Rucz
Karoly Rucz
1st Department of Medicine, University of Pecs, Pecs, Hungary
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Gilles Russ
Gilles Russ
Unité Thyroïde et Tumeurs Endocrines – Pr Leenhardt Hôpital La Pitie Salpetriere, Sorbonne Université, Paris, France
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Endre V Nagy
Endre V Nagy
Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Introduction For more than three decades, the cornerstones in the clinical management of patients with thyroid nodules have been ultrasound (US) and fine-needle aspiration cytology (FNA) ( 1 , 2 , 3 ). Robust evidence demonstrates that the
Kristine Z Swan
Kristine Z Swan
Department of ORL, Head- and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark
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Johnson Thomas
Johnson Thomas
Department of Endocrinology, Mercy Hospital, Springfield, Missouri, USA
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Viveque E Nielsen
Viveque E Nielsen
Department of ORL, Head- and Neck Surgery, Odense University Hospital, Odense, Denmark
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Marie Louise Jespersen
Marie Louise Jespersen
Department of Pathology, Aarhus University Hospital, Aarhus, Denmark
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Steen J Bonnema
Steen J Bonnema
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Introduction Risk stratification of thyroid nodules uses ultrasound features predictive of benign or malignant disease to identify nodules that should undergo biopsy. Biopsy is an invasive procedure and may not yield a final diagnosis one out
Aglaia Kyrilli
Aglaia Kyrilli
Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium
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Nunzia Tacelli
Nunzia Tacelli
Department of Radiology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium
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Lucia Russo
Lucia Russo
Department of Medicine, DIMED, Internal Medicine 3, University of Padua, Via Giustiniani 2, 35128, Padova, Italy
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Laetitia Lebrun
Laetitia Lebrun
Department of Pathology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium
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Isabelle Salmon
Isabelle Salmon
Department of Pathology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium
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Gilles Russ
Gilles Russ
Thyroid and Endocrine Tumors, Institute of Endocrinology, Pitié Salpêtrière Hospital, Pierre et Marie Curie University, Paris, France
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Rodrigo Moreno-Reyes
Rodrigo Moreno-Reyes
Department of Nuclear Medicine, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik, Brussels, Belgium
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Bernard Corvilain
Bernard Corvilain
Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.)– Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium
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crucial determinants of serum TSH ( 10 , 11 , 12 , 13 , 14 ). When scintigraphy is routinely performed in thyroid nodule workup, it allows detection of AFTN at early stages before progression to subclinical and/or overt hyperthyroidism. Ultrasound
Hai-Yan Jia
Hai-Yan Jia
Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Juan Chen
Juan Chen
Department of Ultrasound, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China
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Zi-Xin Zhai
Zi-Xin Zhai
Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Wen-Wen Fan
Wen-Wen Fan
Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Si-Jie Yuan
Si-Jie Yuan
Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Qiong Liu
Qiong Liu
Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Xiao-Hui Yan
Xiao-Hui Yan
Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Qian-Qian Shen
Qian-Qian Shen
Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Li-Ping Liu
Li-Ping Liu
Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
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Established facts Already known fact 1: Thyroid metastasis from ccRCC is relatively rare, so ultrasound doctors lack experience with the disease, which can easily lead to misdiagnosis. There is little discussion about its ultrasonographic
J L Reverter
J L Reverter
Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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L Ferrer-Estopiñan
L Ferrer-Estopiñan
Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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F Vázquez
F Vázquez
Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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S Ballesta
S Ballesta
Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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S Batule
S Batule
Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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A Perez-Montes de Oca
A Perez-Montes de Oca
Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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C Puig-Jové
C Puig-Jové
Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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M Puig-Domingo
M Puig-Domingo
Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain
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nodules has enhanced the need for endocrinologists to be able to define the risk of malignancy as accurately as possible ( 2 ). Ultrasound (US) is the first-line method to identify malignant thyroid nodules with the advantages of accessibility, cost
Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Laszlo Hegedüs
Laszlo Hegedüs
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Agnieszka Czarniecka
Agnieszka Czarniecka
M. Sklodowska-Curie National Research, Institute of Oncology Gliwice Branch, Gliwice, Poland
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Ralf Paschke
Ralf Paschke
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Gilles Russ
Gilles Russ
Thyroid and Endocrine Tumors Department, Pitié-Salpêtrière Hospital, Sorbonne University GRC N°16, Paris, France
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Fernando Schmitt
Fernando Schmitt
Faculty of Medicine of University of Porto, CINTESIS@RISE and Institute of Molecular Pathology and Immunology, University of Porto (Ipatimup), Porto, Portugal
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Paula Soares
Paula Soares
Institute of Investigation and Innovation in Health (I3S), Faculty of Medicine of the University of Porto, Porto, Portugal
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Tamas Solymosi
Tamas Solymosi
Endocrinology and Metabolism Clinic, Bugat Hospital, Gyöngyös, Hungary
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Enrico Papini
Enrico Papini
Department of Endocrine and Metabolic Diseases, Regina Apostolorum Hospital, Albano, Rome, Italy
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patient into consideration. Based on the aforementioned, ultrasound (US) screening of asymptomatic adults is discouraged. Thus, the present guidelines aim at providing a clinical practice guide for the initial workup and the subsequent management of adult
M Grussendorf
M Grussendorf
Department of Internal Medicine, University Hospital, Düsseldorf, Germany
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I Ruschenburg
I Ruschenburg
MVZ Wagnerstibbe Center for Cytology and Pathology, Einbeck, Germany
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G Brabant
G Brabant
Department of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, UK
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Introduction Inclusion of thyroid ultrasound in the routine diagnostic workup greatly increased the number of thyroid nodules detected ( 1 , 2 , 3 , 4 , 5 ). According to epidemiological studies, a prevalence of up to 65% of the adult
Eduardo Crespo Vallejo
Eduardo Crespo Vallejo
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Antonio Hermosin
Antonio Hermosin
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Manuel Gargallo
Manuel Gargallo
Endocrinology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Álvaro Villalba
Álvaro Villalba
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Eduardo Daguer
Eduardo Daguer
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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José Flores
José Flores
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Javier Periañez
Javier Periañez
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Joaquim Amorín
Joaquim Amorín
Interventional Radiology, Hospital Universitario Fundacion Jiménez Diaz, Madrid, Spain
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Ernesto Santos
Ernesto Santos
Interventional Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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and/or esthetic discomfort ( 3 , 4 ) surgery is traditionally viewed as the first-line treatment. However, surgery for benign TNs is likely to be presently overused in Europe ( 5 ), and ultrasound-guided interventional techniques stand as a reasonable
Tommaso Piticchio
Tommaso Piticchio
Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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Gilles Russ
Gilles Russ
Department of Thyroid and Endocrine Tumor Diseases, La Pitie-Salpetriere Hospital, 83 Bd de l’Hopital, Paris, France
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Maija Radzina
Maija Radzina
Riga Stradins University, Radiology Research Laboratory, Riga, Latvia
University of Latvia, Faculty of Medicine, Riga, Latvia
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University of Latvia, Faculty of Medicine, Riga, Latvia
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Francesco Frasca
Francesco Frasca
Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy
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Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Pierpaolo Trimboli
Pierpaolo Trimboli
Servizio di Endocrinologia e Diabetologia, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland
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Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Lugano, Switzerland
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). Considering the epidemiological figures and potential oncological implications, international guidelines recommend an immediate malignancy risk assessment for newly diagnosed TNs, and ultrasound (US) is universally recognized as the first-line diagnostic
