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, aiming for a universal substitution dose of 1.6 μg/kg body weight per day might hold a risk of overtreatment, especially in elderly patients. But no matter which guidance is followed, one should be aware that due to the important interindividual variation
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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a reduced generation of ROS but may be counterbalanced by a diminished antioxidant capacity. Complexity is underlined by the observation that untreated hypothyroidism, unless severe, may benefit elderly people in terms of longevity ( 30 ), although
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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infection . European Journal of Endocrinology 2021 184 699 – 709 . ( https://doi.org/10.1530/EJE-20-1391 ) 31 Bhakri HL Fisher R Khadri A & MacMahon DG . Longitudinal study of thyroid function in acutely ill elderly patients using a sensitive
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a third generation TSH assay is not available in an iodine sufficient area, an upper limit of normal of 4.12 should be considered” [ 20 ]. Similarly, Latin American Thyroid Society recommendations are “against routine treatment for elderly (>65 years
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when an intravenous preparation is unavailable for the treatment of myxedema coma. Myxedema coma is most commonly described in elderly women, but in this study, 78.6% of subjects were males. This may reflect the gender disparity in healthcare
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findings to other populations. Coexistence of MetS and TD may aggravate their common metabolic features which might strongly impact the health of populations especially in hypothyroid elderly subjects regarding cardiovascular and metabolic risk factors