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: Starting the treatment with diuretics alone resulted in immediate improvement of visual acuity. As evidenced by MRI, the mechanism is a decrease in the water content of orbital tissues. These findings suggest that the addition of diuretics to the standard
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(DON) and/or exophthalmos-related corneal breakdown, requiring prompt treatment with very high doses of i.v. glucocorticoids (ivGCs), local treatments, and/or orbital decompression surgery ( 5 ). True challenges and therapeutic dilemmas are posed by
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Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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soon as possible to avoid delays in treatment. Therefore, it is crucial to predict the response of TED patients to GC therapy before initiating treatment. Through this study, we aimed to obtain a simple and accurate method to help predict the response
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Endocrinology Division, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA
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therapy 5.1. Local and lifestyle measures In addition to optimally controlling hyperthyroidism as described in clinical practice guidelines ( 4 , 18 ), some nonsystemic treatments and lifestyle measures can be beneficial in TED. Dry eye is common
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Introduction Graves’ orbitopathy (GO) is the most common orbital disease in adults, which greatly affects patients’ quality of life ( 1 , 2 , 3 ). Although bioagents such as teprotumumab showed a promising new paradigm in GO treatment ( 4
Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China
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criteria were applied to all groups: (i) thyroid cancer or other malignant disease; (ii) thyroid dysfunction, exposure to radioactive iodine treatment, antithyroid medication or thyroid hormone replacement; (iii) systemic autoimmune disease, acute
Ilisimatusarfik, University of Greenland, Nuuk, Greenland
National Board of Health, Nuuk, Greenland
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Ilisimatusarfik, University of Greenland, Nuuk, Greenland
Department of Internal Medicine, Queen Ingrid’s Hospital, Nuuk, Greenland
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Queen Ingrid’s Health Care Centre, Nuuk, Greenland
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Ilisimatusarfik, University of Greenland, Nuuk, Greenland
Department of Internal Medicine, Queen Ingrid’s Hospital, Nuuk, Greenland
Department of Geriatric Medicine, Aalborg University Hospital, Aalborg, Denmark
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informed consent form in participant’s chosen language (Greenlandic or Danish). Investigational procedures A letter of invitation (in Greenlandic and Danish) was personally delivered to each subject by the local healthcare personnel. The invitations
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role in the early phase of the disease. In patients with active and relapsing GD, high serum CXCL10 levels are found which decrease after treatment. Those observations suggested that although Th2 cells were initially considered as the predominant